Targeting hypoxia-inducible factor-1 in a hypoxidative stress model protects retinal pigment epithelium cells from cell death and metabolic dysregulation

Targeting hypoxia-inducible factor-1 in a hypoxidative stress model protects retinal pigment epithelium cells from cell death and metabolic dysregulation

Abstract Oxidative stress and hypoxia lead to dysfunction of retinal pigment epithelium (RPE) cells and are hallmarks of diseases such as age-related macular degeneration (AMD), the most common blinding disease in the elderly population. We have previously shown that a combination of these two risk...

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Bibliographic Details
Main Authors: Annika Schubert, Maria Eduarda Lobo Barbosa da Silva, Tabea Ambrock, Orbel Terosian, Anna Malyshkina, Claudia Padberg, Safa Larafa, Johann Matschke, Joachim Fandrey, Yoshiyuki Henning
Format: Article
Language:English
Published: Nature Publishing Group 2025-08-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-025-02675-7
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