Balance and management of CRS and infection following CD19-targeted CAR T-cell therapy in primary refractory high-grade B-cell lymphoma: a case report

Balance and management of CRS and infection following CD19-targeted CAR T-cell therapy in primary refractory high-grade B-cell lymphoma: a case report

BackgroundCD19-targeted chimeric antigen receptor T (CAR T) cell therapy has revolutionized the treatment of refractory/relapsed B-cell malignancies. However, this therapy introduces significant safety concerns, including cytokine release syndrome (CRS) and infections, both of which can lead to life...

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Bibliographic Details
Main Authors: Nannan Lu, Yajing Zhang, Chunmeng Wang, Qingming Yang, Guanghua Rong, Yang Liu, Weidong Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Hematology
Subjects:
B-cell lymphoma
CAR T-cell therapy
cytokine release syndrome
herpesvirus infection
corticosteroids
Online Access:https://www.frontiersin.org/articles/10.3389/frhem.2025.1616504/full
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