Intestinal Immunomodulatory Cells (T Lymphocytes): A Bridge between Gut Microbiota and Diabetes
Diabetes mellitus (DM) is one of the most familiar chronic diseases threatening human health. Recent studies have shown that the development of diabetes is closely related to an imbalance of the gut microbiota. Accordingly, there is increasing interest in how changes in the gut microbiota affect dia...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2018/9830939 |
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| author | Qingwei Li Zezheng Gao Han Wang Haoran Wu Yanwen Liu Yingying Yang Lin Han Xinmiao Wang Linhua Zhao Xiaolin Tong |
| author_facet | Qingwei Li Zezheng Gao Han Wang Haoran Wu Yanwen Liu Yingying Yang Lin Han Xinmiao Wang Linhua Zhao Xiaolin Tong |
| author_sort | Qingwei Li |
| collection | DOAJ |
| description | Diabetes mellitus (DM) is one of the most familiar chronic diseases threatening human health. Recent studies have shown that the development of diabetes is closely related to an imbalance of the gut microbiota. Accordingly, there is increasing interest in how changes in the gut microbiota affect diabetes and its underlying mechanisms. Immunomodulatory cells play important roles in maintaining the normal functioning of the human immune system and in maintaining homeostasis. Intestinal immunomodulatory cells (IICs) are located in the intestinal mucosa and are regarded as an intermediary by which the gut microbiota affects physiological and pathological properties. Diabetes can be regulated by IICs, which act as a bridge linking the gut microbiota and DM. Understanding this bridge role of IICs may clarify the mechanisms by which the gut microbiota contributes to DM. Based on recent research, we summarize this process, thereby providing a basis for further studies of diabetes and other similar immune-related diseases. |
| format | Article |
| id | doaj-art-df4768e7151144e7a191b3eb9ac3087d |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-df4768e7151144e7a191b3eb9ac3087d2025-02-03T01:31:34ZengWileyMediators of Inflammation0962-93511466-18612018-01-01201810.1155/2018/98309399830939Intestinal Immunomodulatory Cells (T Lymphocytes): A Bridge between Gut Microbiota and DiabetesQingwei Li0Zezheng Gao1Han Wang2Haoran Wu3Yanwen Liu4Yingying Yang5Lin Han6Xinmiao Wang7Linhua Zhao8Xiaolin Tong9Department of Endocrinology, Guang’anmen Hospital of China, Academy of Chinese Medical Sciences, Beijing 100053, ChinaDepartment of Endocrinology, Guang’anmen Hospital of China, Academy of Chinese Medical Sciences, Beijing 100053, ChinaShenzhen Hospital, Guangzhou University of Chinese Medicine, Guangzhou 518034, ChinaDepartment of Endocrinology, Guang’anmen Hospital of China, Academy of Chinese Medical Sciences, Beijing 100053, ChinaDepartment of Endocrinology, Guang’anmen Hospital of China, Academy of Chinese Medical Sciences, Beijing 100053, ChinaDepartment of Endocrinology, Guang’anmen Hospital of China, Academy of Chinese Medical Sciences, Beijing 100053, ChinaDepartment of Endocrinology, Guang’anmen Hospital of China, Academy of Chinese Medical Sciences, Beijing 100053, ChinaDepartment of Endocrinology, Guang’anmen Hospital of China, Academy of Chinese Medical Sciences, Beijing 100053, ChinaDepartment of Endocrinology, Guang’anmen Hospital of China, Academy of Chinese Medical Sciences, Beijing 100053, ChinaDepartment of Endocrinology, Guang’anmen Hospital of China, Academy of Chinese Medical Sciences, Beijing 100053, ChinaDiabetes mellitus (DM) is one of the most familiar chronic diseases threatening human health. Recent studies have shown that the development of diabetes is closely related to an imbalance of the gut microbiota. Accordingly, there is increasing interest in how changes in the gut microbiota affect diabetes and its underlying mechanisms. Immunomodulatory cells play important roles in maintaining the normal functioning of the human immune system and in maintaining homeostasis. Intestinal immunomodulatory cells (IICs) are located in the intestinal mucosa and are regarded as an intermediary by which the gut microbiota affects physiological and pathological properties. Diabetes can be regulated by IICs, which act as a bridge linking the gut microbiota and DM. Understanding this bridge role of IICs may clarify the mechanisms by which the gut microbiota contributes to DM. Based on recent research, we summarize this process, thereby providing a basis for further studies of diabetes and other similar immune-related diseases.http://dx.doi.org/10.1155/2018/9830939 |
| spellingShingle | Qingwei Li Zezheng Gao Han Wang Haoran Wu Yanwen Liu Yingying Yang Lin Han Xinmiao Wang Linhua Zhao Xiaolin Tong Intestinal Immunomodulatory Cells (T Lymphocytes): A Bridge between Gut Microbiota and Diabetes Mediators of Inflammation |
| title | Intestinal Immunomodulatory Cells (T Lymphocytes): A Bridge between Gut Microbiota and Diabetes |
| title_full | Intestinal Immunomodulatory Cells (T Lymphocytes): A Bridge between Gut Microbiota and Diabetes |
| title_fullStr | Intestinal Immunomodulatory Cells (T Lymphocytes): A Bridge between Gut Microbiota and Diabetes |
| title_full_unstemmed | Intestinal Immunomodulatory Cells (T Lymphocytes): A Bridge between Gut Microbiota and Diabetes |
| title_short | Intestinal Immunomodulatory Cells (T Lymphocytes): A Bridge between Gut Microbiota and Diabetes |
| title_sort | intestinal immunomodulatory cells t lymphocytes a bridge between gut microbiota and diabetes |
| url | http://dx.doi.org/10.1155/2018/9830939 |
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