Sodium‐Glucose Cotransporter 2 Inhibitors for Mesenchymal–Epithelial Transition Inhibitor‐Induced Edema
ABSTRACT The effects of sodium‐glucose cotransporter 2 (SGLT2) inhibitors on mesenchymal‐epithelial transition factor (MET) inhibitor‐induced edema remain unclear. In a patient with tepotinib‐induced edema and an N‐terminal pro‐brain natriuretic peptide (NTproBNP) level ≥ 300 pg/mL, the addition of...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Thoracic Cancer |
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| Online Access: | https://doi.org/10.1111/1759-7714.15509 |
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| author | Takuya Oyakawa Keita Miura Nao Muraoka Kei Iida Ayano Fujita Tateaki Naito Toshiaki Takahashi |
| author_facet | Takuya Oyakawa Keita Miura Nao Muraoka Kei Iida Ayano Fujita Tateaki Naito Toshiaki Takahashi |
| author_sort | Takuya Oyakawa |
| collection | DOAJ |
| description | ABSTRACT The effects of sodium‐glucose cotransporter 2 (SGLT2) inhibitors on mesenchymal‐epithelial transition factor (MET) inhibitor‐induced edema remain unclear. In a patient with tepotinib‐induced edema and an N‐terminal pro‐brain natriuretic peptide (NTproBNP) level ≥ 300 pg/mL, the addition of empagliflozin to loop diuretics reduced the edema. This suggests that empagliflozin may be a treatment option for MET inhibitor‐induced edema. |
| format | Article |
| id | doaj-art-df45f03b0a844f77ac9faf3cc57e70b1 |
| institution | Kabale University |
| issn | 1759-7706 1759-7714 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj-art-df45f03b0a844f77ac9faf3cc57e70b12025-01-30T22:40:34ZengWileyThoracic Cancer1759-77061759-77142025-01-01162n/an/a10.1111/1759-7714.15509Sodium‐Glucose Cotransporter 2 Inhibitors for Mesenchymal–Epithelial Transition Inhibitor‐Induced EdemaTakuya Oyakawa0Keita Miura1Nao Muraoka2Kei Iida3Ayano Fujita4Tateaki Naito5Toshiaki Takahashi6Division of Cardio‐oncology Shizuoka Cancer Center Shizuoka JapanDivision of Thoracic oncology Shizuoka Cancer Center Shizuoka JapanDivision of Cardio‐oncology Shizuoka Cancer Center Shizuoka JapanDivision of Cardio‐oncology Shizuoka Cancer Center Shizuoka JapanDivision of Cardio‐oncology Shizuoka Cancer Center Shizuoka JapanDivision of Thoracic oncology Shizuoka Cancer Center Shizuoka JapanDivision of Thoracic oncology Shizuoka Cancer Center Shizuoka JapanABSTRACT The effects of sodium‐glucose cotransporter 2 (SGLT2) inhibitors on mesenchymal‐epithelial transition factor (MET) inhibitor‐induced edema remain unclear. In a patient with tepotinib‐induced edema and an N‐terminal pro‐brain natriuretic peptide (NTproBNP) level ≥ 300 pg/mL, the addition of empagliflozin to loop diuretics reduced the edema. This suggests that empagliflozin may be a treatment option for MET inhibitor‐induced edema.https://doi.org/10.1111/1759-7714.15509cardio‐oncologyedemalung cancerMETSGLT2 inhibitor |
| spellingShingle | Takuya Oyakawa Keita Miura Nao Muraoka Kei Iida Ayano Fujita Tateaki Naito Toshiaki Takahashi Sodium‐Glucose Cotransporter 2 Inhibitors for Mesenchymal–Epithelial Transition Inhibitor‐Induced Edema Thoracic Cancer cardio‐oncology edema lung cancer MET SGLT2 inhibitor |
| title | Sodium‐Glucose Cotransporter 2 Inhibitors for Mesenchymal–Epithelial Transition Inhibitor‐Induced Edema |
| title_full | Sodium‐Glucose Cotransporter 2 Inhibitors for Mesenchymal–Epithelial Transition Inhibitor‐Induced Edema |
| title_fullStr | Sodium‐Glucose Cotransporter 2 Inhibitors for Mesenchymal–Epithelial Transition Inhibitor‐Induced Edema |
| title_full_unstemmed | Sodium‐Glucose Cotransporter 2 Inhibitors for Mesenchymal–Epithelial Transition Inhibitor‐Induced Edema |
| title_short | Sodium‐Glucose Cotransporter 2 Inhibitors for Mesenchymal–Epithelial Transition Inhibitor‐Induced Edema |
| title_sort | sodium glucose cotransporter 2 inhibitors for mesenchymal epithelial transition inhibitor induced edema |
| topic | cardio‐oncology edema lung cancer MET SGLT2 inhibitor |
| url | https://doi.org/10.1111/1759-7714.15509 |
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