Increased Toll-Like Receptor 2 Expression in Peptidoglycan-Treated Blood Monocytes Is Associated with Insulin Resistance in Patients with Nondiabetic Rheumatoid Arthritis
The close relationship between increased TLR-2 expression in blood monocytes and insulin resistance in RA patients is shown in this study. Traditional risk factors for metabolic disorders, including the waist circumstance, body mass index (BMI), triglyceride (TG), and ratio of TG to high density lip...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/690525 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832551498965319680 |
|---|---|
| author | Shih-Wei Wang Tsun-Mei Lin Chiou-Huey Wang Hsiao-Han Liu Jer-Yiing Houng |
| author_facet | Shih-Wei Wang Tsun-Mei Lin Chiou-Huey Wang Hsiao-Han Liu Jer-Yiing Houng |
| author_sort | Shih-Wei Wang |
| collection | DOAJ |
| description | The close relationship between increased TLR-2 expression in blood monocytes and insulin resistance in RA patients is shown in this study. Traditional risk factors for metabolic disorders, including the waist circumstance, body mass index (BMI), triglyceride (TG), and ratio of TG to high density lipoprotein (HDL) cholesterol, were closely correlated with HOMA (homoeostasis model assessment) index in patients with nondiabetic RA. Expressions of TLR2 in peripheral blood monocytes, following stimulation with peptidoglycan which is known as a TLR2 agonist, were closely correlated with the HOMA index, TNF-α, and IL-6 concentrations. Accordingly, TLR-2 receptor and its related inflammatory cytokines could be potential therapeutic targets in managing insulin resistance in RA patients. |
| format | Article |
| id | doaj-art-df3688c2f53f4a43bd0594f4ff1867d9 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-df3688c2f53f4a43bd0594f4ff1867d92025-02-03T06:01:28ZengWileyMediators of Inflammation0962-93511466-18612012-01-01201210.1155/2012/690525690525Increased Toll-Like Receptor 2 Expression in Peptidoglycan-Treated Blood Monocytes Is Associated with Insulin Resistance in Patients with Nondiabetic Rheumatoid ArthritisShih-Wei Wang0Tsun-Mei Lin1Chiou-Huey Wang2Hsiao-Han Liu3Jer-Yiing Houng4Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, E-DA Hospital, No. 1 Yida Road, Yanchao District, Kaohsiung 82445, TaiwanDepartment of Medical Laboratory, E-DA Hospital and I-Shou University, No. 1 Yida Road, Yanchao District, Kaohsiung 82445, TaiwanDepartment of Medical Laboratory, E-DA Hospital and I-Shou University, No. 1 Yida Road, Yanchao District, Kaohsiung 82445, TaiwanDepartment of Biological Science and Technology, I-Shou University, No. 8 Yida Road, Yanchao District, Kaohsiung 82445, TaiwanInstitute of Biotechnology and Chemical Engineering, I-Shou University, Section 1, No. 1 Syuecheng Road, Dashu District, Kaohsiung 84001, TaiwanThe close relationship between increased TLR-2 expression in blood monocytes and insulin resistance in RA patients is shown in this study. Traditional risk factors for metabolic disorders, including the waist circumstance, body mass index (BMI), triglyceride (TG), and ratio of TG to high density lipoprotein (HDL) cholesterol, were closely correlated with HOMA (homoeostasis model assessment) index in patients with nondiabetic RA. Expressions of TLR2 in peripheral blood monocytes, following stimulation with peptidoglycan which is known as a TLR2 agonist, were closely correlated with the HOMA index, TNF-α, and IL-6 concentrations. Accordingly, TLR-2 receptor and its related inflammatory cytokines could be potential therapeutic targets in managing insulin resistance in RA patients.http://dx.doi.org/10.1155/2012/690525 |
| spellingShingle | Shih-Wei Wang Tsun-Mei Lin Chiou-Huey Wang Hsiao-Han Liu Jer-Yiing Houng Increased Toll-Like Receptor 2 Expression in Peptidoglycan-Treated Blood Monocytes Is Associated with Insulin Resistance in Patients with Nondiabetic Rheumatoid Arthritis Mediators of Inflammation |
| title | Increased Toll-Like Receptor 2 Expression in Peptidoglycan-Treated Blood Monocytes Is Associated with Insulin Resistance in Patients with Nondiabetic Rheumatoid Arthritis |
| title_full | Increased Toll-Like Receptor 2 Expression in Peptidoglycan-Treated Blood Monocytes Is Associated with Insulin Resistance in Patients with Nondiabetic Rheumatoid Arthritis |
| title_fullStr | Increased Toll-Like Receptor 2 Expression in Peptidoglycan-Treated Blood Monocytes Is Associated with Insulin Resistance in Patients with Nondiabetic Rheumatoid Arthritis |
| title_full_unstemmed | Increased Toll-Like Receptor 2 Expression in Peptidoglycan-Treated Blood Monocytes Is Associated with Insulin Resistance in Patients with Nondiabetic Rheumatoid Arthritis |
| title_short | Increased Toll-Like Receptor 2 Expression in Peptidoglycan-Treated Blood Monocytes Is Associated with Insulin Resistance in Patients with Nondiabetic Rheumatoid Arthritis |
| title_sort | increased toll like receptor 2 expression in peptidoglycan treated blood monocytes is associated with insulin resistance in patients with nondiabetic rheumatoid arthritis |
| url | http://dx.doi.org/10.1155/2012/690525 |
| work_keys_str_mv | AT shihweiwang increasedtolllikereceptor2expressioninpeptidoglycantreatedbloodmonocytesisassociatedwithinsulinresistanceinpatientswithnondiabeticrheumatoidarthritis AT tsunmeilin increasedtolllikereceptor2expressioninpeptidoglycantreatedbloodmonocytesisassociatedwithinsulinresistanceinpatientswithnondiabeticrheumatoidarthritis AT chiouhueywang increasedtolllikereceptor2expressioninpeptidoglycantreatedbloodmonocytesisassociatedwithinsulinresistanceinpatientswithnondiabeticrheumatoidarthritis AT hsiaohanliu increasedtolllikereceptor2expressioninpeptidoglycantreatedbloodmonocytesisassociatedwithinsulinresistanceinpatientswithnondiabeticrheumatoidarthritis AT jeryiinghoung increasedtolllikereceptor2expressioninpeptidoglycantreatedbloodmonocytesisassociatedwithinsulinresistanceinpatientswithnondiabeticrheumatoidarthritis |