Mitochondrial Acetylation and Diseases of Aging
In recent years, protein lysine acetylation has emerged as a prominent and conserved regulatory posttranslational modification that is abundant on numerous enzymes involved in the processes of intermediary metabolism. Well-characterized mitochondrial processes of carbon utilization are enriched in a...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | Journal of Aging Research |
| Online Access: | http://dx.doi.org/10.4061/2011/234875 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564225969487872 |
|---|---|
| author | Gregory R. Wagner R. Mark Payne |
| author_facet | Gregory R. Wagner R. Mark Payne |
| author_sort | Gregory R. Wagner |
| collection | DOAJ |
| description | In recent years, protein lysine acetylation has emerged as a prominent and conserved regulatory posttranslational modification that is abundant on numerous enzymes involved in the processes of intermediary metabolism. Well-characterized mitochondrial processes of carbon utilization are enriched in acetyl-lysine modifications. Although seminal discoveries have been made in the basic biology of mitochondrial acetylation, an understanding of how acetylation states influence enzyme function and metabolic reprogramming during pathological states remains largely unknown. This paper will examine our current understanding of eukaryotic acetate metabolism and present recent findings in the field of mitochondrial acetylation biology. The implications of mitochondrial acetylation for the aging process will be discussed, as well as its potential implications for the unique and localized metabolic states that occur during the aging-associated conditions of heart failure and cancer growth. |
| format | Article |
| id | doaj-art-df2cc2a3e5ae46308aba66ea838a7af7 |
| institution | Kabale University |
| issn | 2090-2212 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Aging Research |
| spelling | doaj-art-df2cc2a3e5ae46308aba66ea838a7af72025-02-03T01:11:32ZengWileyJournal of Aging Research2090-22122011-01-01201110.4061/2011/234875234875Mitochondrial Acetylation and Diseases of AgingGregory R. Wagner0R. Mark Payne1Department of Medical & Molecular Genetics, Riley Heart Research Center, Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USADepartment of Medical & Molecular Genetics, Riley Heart Research Center, Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USAIn recent years, protein lysine acetylation has emerged as a prominent and conserved regulatory posttranslational modification that is abundant on numerous enzymes involved in the processes of intermediary metabolism. Well-characterized mitochondrial processes of carbon utilization are enriched in acetyl-lysine modifications. Although seminal discoveries have been made in the basic biology of mitochondrial acetylation, an understanding of how acetylation states influence enzyme function and metabolic reprogramming during pathological states remains largely unknown. This paper will examine our current understanding of eukaryotic acetate metabolism and present recent findings in the field of mitochondrial acetylation biology. The implications of mitochondrial acetylation for the aging process will be discussed, as well as its potential implications for the unique and localized metabolic states that occur during the aging-associated conditions of heart failure and cancer growth.http://dx.doi.org/10.4061/2011/234875 |
| spellingShingle | Gregory R. Wagner R. Mark Payne Mitochondrial Acetylation and Diseases of Aging Journal of Aging Research |
| title | Mitochondrial Acetylation and Diseases of Aging |
| title_full | Mitochondrial Acetylation and Diseases of Aging |
| title_fullStr | Mitochondrial Acetylation and Diseases of Aging |
| title_full_unstemmed | Mitochondrial Acetylation and Diseases of Aging |
| title_short | Mitochondrial Acetylation and Diseases of Aging |
| title_sort | mitochondrial acetylation and diseases of aging |
| url | http://dx.doi.org/10.4061/2011/234875 |
| work_keys_str_mv | AT gregoryrwagner mitochondrialacetylationanddiseasesofaging AT rmarkpayne mitochondrialacetylationanddiseasesofaging |