Intensive Care Management of Patients with Acute Liver Failure with Emphasis on Systemic Hemodynamic Instability and Cerebral Edema: A Critical Appraisal of Pathophysiology
Acute liver failure (ALF) is a devastating disease leading to multiorgan dysfunction. The most dramatic impact of ALF is on the brain, as hepatic encephalopathy and intracranial hypertension (IH) develop. IH is associated with systemic hemodynamic instability, alterations in the regulation of cerebr...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2000-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2000/493629 |
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| _version_ | 1832555961457311744 |
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| author | Fin Stolze Larsen Bent Adel Hansen Andres T Blei |
| author_facet | Fin Stolze Larsen Bent Adel Hansen Andres T Blei |
| author_sort | Fin Stolze Larsen |
| collection | DOAJ |
| description | Acute liver failure (ALF) is a devastating disease
leading to multiorgan dysfunction. The most dramatic impact of
ALF is on the brain, as hepatic encephalopathy and intracranial
hypertension (IH) develop. IH is associated with systemic hemodynamic
instability, alterations in the regulation of cerebral blood
flow and the development of cerebral edema. This review focuses
on the pathophysiology of IH with special emphasis on cerebral
blood flow and the development of cerebral edema. Based on these
considerations, both traditional and new treatments for the management
of IH in the future are discussed. |
| format | Article |
| id | doaj-art-df28d2845bd34d74a3fd13d39821f2d7 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2000-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-df28d2845bd34d74a3fd13d39821f2d72025-02-03T05:46:49ZengWileyCanadian Journal of Gastroenterology0835-79002000-01-0114Suppl D105D111D10.1155/2000/493629Intensive Care Management of Patients with Acute Liver Failure with Emphasis on Systemic Hemodynamic Instability and Cerebral Edema: A Critical Appraisal of PathophysiologyFin Stolze Larsen0Bent Adel Hansen1Andres T Blei2Department of Hepatology, Rigshospitalet, Copenhagen University Hospital, DenmarkDepartment of Hepatology, Rigshospitalet, Copenhagen University Hospital, DenmarkDepartment of Medicine, Veterans Administration Lakeside Medical Center, Northwestern University, Chicago, Illinois, USAAcute liver failure (ALF) is a devastating disease leading to multiorgan dysfunction. The most dramatic impact of ALF is on the brain, as hepatic encephalopathy and intracranial hypertension (IH) develop. IH is associated with systemic hemodynamic instability, alterations in the regulation of cerebral blood flow and the development of cerebral edema. This review focuses on the pathophysiology of IH with special emphasis on cerebral blood flow and the development of cerebral edema. Based on these considerations, both traditional and new treatments for the management of IH in the future are discussed.http://dx.doi.org/10.1155/2000/493629 |
| spellingShingle | Fin Stolze Larsen Bent Adel Hansen Andres T Blei Intensive Care Management of Patients with Acute Liver Failure with Emphasis on Systemic Hemodynamic Instability and Cerebral Edema: A Critical Appraisal of Pathophysiology Canadian Journal of Gastroenterology |
| title | Intensive Care Management of Patients with Acute Liver Failure with Emphasis on Systemic Hemodynamic Instability and Cerebral Edema: A Critical Appraisal of Pathophysiology |
| title_full | Intensive Care Management of Patients with Acute Liver Failure with Emphasis on Systemic Hemodynamic Instability and Cerebral Edema: A Critical Appraisal of Pathophysiology |
| title_fullStr | Intensive Care Management of Patients with Acute Liver Failure with Emphasis on Systemic Hemodynamic Instability and Cerebral Edema: A Critical Appraisal of Pathophysiology |
| title_full_unstemmed | Intensive Care Management of Patients with Acute Liver Failure with Emphasis on Systemic Hemodynamic Instability and Cerebral Edema: A Critical Appraisal of Pathophysiology |
| title_short | Intensive Care Management of Patients with Acute Liver Failure with Emphasis on Systemic Hemodynamic Instability and Cerebral Edema: A Critical Appraisal of Pathophysiology |
| title_sort | intensive care management of patients with acute liver failure with emphasis on systemic hemodynamic instability and cerebral edema a critical appraisal of pathophysiology |
| url | http://dx.doi.org/10.1155/2000/493629 |
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