Intensive Care Management of Patients with Acute Liver Failure with Emphasis on Systemic Hemodynamic Instability and Cerebral Edema: A Critical Appraisal of Pathophysiology
Acute liver failure (ALF) is a devastating disease leading to multiorgan dysfunction. The most dramatic impact of ALF is on the brain, as hepatic encephalopathy and intracranial hypertension (IH) develop. IH is associated with systemic hemodynamic instability, alterations in the regulation of cerebr...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2000-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2000/493629 |
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| Summary: | Acute liver failure (ALF) is a devastating disease
leading to multiorgan dysfunction. The most dramatic impact of
ALF is on the brain, as hepatic encephalopathy and intracranial
hypertension (IH) develop. IH is associated with systemic hemodynamic
instability, alterations in the regulation of cerebral blood
flow and the development of cerebral edema. This review focuses
on the pathophysiology of IH with special emphasis on cerebral
blood flow and the development of cerebral edema. Based on these
considerations, both traditional and new treatments for the management
of IH in the future are discussed. |
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| ISSN: | 0835-7900 |