Intervention effects of Naoxintong capsules on psychological and cardiac status in depressed rats after heart failure
Abstract. Background. Depression is a common clinical phenomenon in the patients with heart failure (HF). In traditional Chinese medicine (TCM), diseases in the brain and heart are thought to be correlated and interact. Naoxintong capsules (NXT) has been used for treating cardio-cerebrovascular dise...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Health/LWW
2024-12-01
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| Series: | Science of Traditional Chinese Medicine |
| Online Access: | http://journals.lww.com/10.1097/st9.0000000000000044 |
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| author | Jie Zhao Yi Ouyang Shaowei Hu Guanghuan Tian Xixian Kong Fuzhu Pan Hongwei Wu Liying Tang Hongjun Yang |
| author_facet | Jie Zhao Yi Ouyang Shaowei Hu Guanghuan Tian Xixian Kong Fuzhu Pan Hongwei Wu Liying Tang Hongjun Yang |
| author_sort | Jie Zhao |
| collection | DOAJ |
| description | Abstract. Background. Depression is a common clinical phenomenon in the patients with heart failure (HF). In traditional Chinese medicine (TCM), diseases in the brain and heart are thought to be correlated and interact. Naoxintong capsules (NXT) has been used for treating cardio-cerebrovascular diseases, while its therapeutic effect on depression after HF remains unclear.
Objective. The aim of the study is to evaluate the intervention effect of NXT on depression after HF.
Methods. Sprague-Dawley rats were assigned into the following 5 groups: sham, model, NXT (250, 1000 mg/kg), and valsartan (8 mg/kg). Coronary artery occlusion was performed to induce HF and subsequent depression in rats. The cardiac function was evaluated by echocardiography, hematoxylin-eosin staining, and Masson trichrome staining. The sucrose preference test and Morris water maze test were carried out to assess the depressive behaviors in rats. The ultrastructure of hippocampal CA1 neurons was observed and the levels of corticotropin-releasing hormone in the hypothalamus, brain-derived neurotrophic factor in the cortex, and adrenocorticotropic hormone (ACTH) in the plasma were determined by enzyme-linked immunosorbent assay. The levels of dopamine, 5-hydroxytryptamine, norepinephrine, and γ-aminobutyric acid in the hippocampus were measured by UPLC-QQQ-MS.
Results. NXT reduced myocardial injury and pathological changes in the cardiac tissue and increased the left ventricular ejection fraction, left ventricular fractional shortening, and cardiac output. NXT increased the sugar preference rate and number of crossings and shortened the escape latency. Furthermore, the NXT treatment restored the levels of corticotropin-releasing hormone, adrenocorticotropic hormone, brain-derived neurotrophic factor, dopamine, and γ-aminobutyric acid to the baseline values.
Conclusions. NXT not only demonstrates cardioprotective effect but also attenuates depression in the rats after HF. It may exert the antidepressant effect by inhibiting the hyperactivity of the hypothalamic-pituitary-adrenal axis and recovering the levels of neurotrophic factors and neurotransmitters. |
| format | Article |
| id | doaj-art-df2710a1cb15459baf1c02c98a4251c6 |
| institution | OA Journals |
| issn | 2836-922X 2836-9211 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Science of Traditional Chinese Medicine |
| spelling | doaj-art-df2710a1cb15459baf1c02c98a4251c62025-08-20T02:07:57ZengWolters Kluwer Health/LWWScience of Traditional Chinese Medicine2836-922X2836-92112024-12-012431932610.1097/st9.0000000000000044202412000-00008Intervention effects of Naoxintong capsules on psychological and cardiac status in depressed rats after heart failureJie Zhao0Yi Ouyang1Shaowei Hu2Guanghuan Tian3Xixian Kong4Fuzhu Pan5Hongwei Wu6Liying Tang7Hongjun Yang8a Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment for Major Diseases, Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing, Chinab Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, Chinab Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, Chinac Zunyi Medical University, Guiyang, Chinab Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, Chinac Zunyi Medical University, Guiyang, Chinab Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, Chinab Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, Chinaa Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment for Major Diseases, Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing, ChinaAbstract. Background. Depression is a common clinical phenomenon in the patients with heart failure (HF). In traditional Chinese medicine (TCM), diseases in the brain and heart are thought to be correlated and interact. Naoxintong capsules (NXT) has been used for treating cardio-cerebrovascular diseases, while its therapeutic effect on depression after HF remains unclear. Objective. The aim of the study is to evaluate the intervention effect of NXT on depression after HF. Methods. Sprague-Dawley rats were assigned into the following 5 groups: sham, model, NXT (250, 1000 mg/kg), and valsartan (8 mg/kg). Coronary artery occlusion was performed to induce HF and subsequent depression in rats. The cardiac function was evaluated by echocardiography, hematoxylin-eosin staining, and Masson trichrome staining. The sucrose preference test and Morris water maze test were carried out to assess the depressive behaviors in rats. The ultrastructure of hippocampal CA1 neurons was observed and the levels of corticotropin-releasing hormone in the hypothalamus, brain-derived neurotrophic factor in the cortex, and adrenocorticotropic hormone (ACTH) in the plasma were determined by enzyme-linked immunosorbent assay. The levels of dopamine, 5-hydroxytryptamine, norepinephrine, and γ-aminobutyric acid in the hippocampus were measured by UPLC-QQQ-MS. Results. NXT reduced myocardial injury and pathological changes in the cardiac tissue and increased the left ventricular ejection fraction, left ventricular fractional shortening, and cardiac output. NXT increased the sugar preference rate and number of crossings and shortened the escape latency. Furthermore, the NXT treatment restored the levels of corticotropin-releasing hormone, adrenocorticotropic hormone, brain-derived neurotrophic factor, dopamine, and γ-aminobutyric acid to the baseline values. Conclusions. NXT not only demonstrates cardioprotective effect but also attenuates depression in the rats after HF. It may exert the antidepressant effect by inhibiting the hyperactivity of the hypothalamic-pituitary-adrenal axis and recovering the levels of neurotrophic factors and neurotransmitters.http://journals.lww.com/10.1097/st9.0000000000000044 |
| spellingShingle | Jie Zhao Yi Ouyang Shaowei Hu Guanghuan Tian Xixian Kong Fuzhu Pan Hongwei Wu Liying Tang Hongjun Yang Intervention effects of Naoxintong capsules on psychological and cardiac status in depressed rats after heart failure Science of Traditional Chinese Medicine |
| title | Intervention effects of Naoxintong capsules on psychological and cardiac status in depressed rats after heart failure |
| title_full | Intervention effects of Naoxintong capsules on psychological and cardiac status in depressed rats after heart failure |
| title_fullStr | Intervention effects of Naoxintong capsules on psychological and cardiac status in depressed rats after heart failure |
| title_full_unstemmed | Intervention effects of Naoxintong capsules on psychological and cardiac status in depressed rats after heart failure |
| title_short | Intervention effects of Naoxintong capsules on psychological and cardiac status in depressed rats after heart failure |
| title_sort | intervention effects of naoxintong capsules on psychological and cardiac status in depressed rats after heart failure |
| url | http://journals.lww.com/10.1097/st9.0000000000000044 |
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