Recent advances in chirality sensing/recognition using supramolecular macrocycles

Chiral sensing is crucial for understanding and controlling the biological activity of chiral molecule such as carbohydrates, amino acids, and proteins. It also plays a vital role in asymmetric synthesis, drug development, and the advancement of functional materials. Supramolecular macrocycle-based...

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Main Authors: Chunhong Liu, Leyong Wang, Zhouyu Wang, Wanhua Wu, Cheng Yang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-12-01
Series:Supramolecular Materials
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Online Access:http://www.sciencedirect.com/science/article/pii/S2667240525000169
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author Chunhong Liu
Leyong Wang
Zhouyu Wang
Wanhua Wu
Cheng Yang
author_facet Chunhong Liu
Leyong Wang
Zhouyu Wang
Wanhua Wu
Cheng Yang
author_sort Chunhong Liu
collection DOAJ
description Chiral sensing is crucial for understanding and controlling the biological activity of chiral molecule such as carbohydrates, amino acids, and proteins. It also plays a vital role in asymmetric synthesis, drug development, and the advancement of functional materials. Supramolecular macrocycle-based chiral sensors offer unique advantages over traditional small-molecule chiral sensors. This review highlights recent advancements in chiral sensing using supramolecular macrocycles, categorizing them into two primary groups: achiral and chiral macrocycles, based on their configurational features. Furthermore, it systematically outlines the synthetic strategies for these macrocycles, emphasizing their applications in chiral recognition and sensing.
format Article
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institution Kabale University
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publishDate 2025-12-01
publisher KeAi Communications Co., Ltd.
record_format Article
series Supramolecular Materials
spelling doaj-art-df229bbf154b4e4e9902f1fd7c785bd02025-08-20T03:49:46ZengKeAi Communications Co., Ltd.Supramolecular Materials2667-24052025-12-01410010710.1016/j.supmat.2025.100107Recent advances in chirality sensing/recognition using supramolecular macrocyclesChunhong Liu0Leyong Wang1Zhouyu Wang2Wanhua Wu3Cheng Yang4Department of Chemistry, School of Science, Xihua University, Chengdu, Sichuan 610039, PR China; Key Laboratory of Green Chemistry & Technology of Ministry of Education, Sichuan University, Chengdu 610064, ChinaKey Laboratory of Mesoscopic Chemistry of MOE, State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, 210023 Nanjing, ChinaDepartment of Chemistry, School of Science, Xihua University, Chengdu, Sichuan 610039, PR ChinaKey Laboratory of Green Chemistry & Technology of Ministry of Education, Sichuan University, Chengdu 610064, ChinaKey Laboratory of Green Chemistry & Technology of Ministry of Education, Sichuan University, Chengdu 610064, China; Corresponding author.Chiral sensing is crucial for understanding and controlling the biological activity of chiral molecule such as carbohydrates, amino acids, and proteins. It also plays a vital role in asymmetric synthesis, drug development, and the advancement of functional materials. Supramolecular macrocycle-based chiral sensors offer unique advantages over traditional small-molecule chiral sensors. This review highlights recent advancements in chiral sensing using supramolecular macrocycles, categorizing them into two primary groups: achiral and chiral macrocycles, based on their configurational features. Furthermore, it systematically outlines the synthetic strategies for these macrocycles, emphasizing their applications in chiral recognition and sensing.http://www.sciencedirect.com/science/article/pii/S2667240525000169Supramolecular macrocyclesChirality sensingChiral sensorsNon-covalent interactionEnantioselective recognition
spellingShingle Chunhong Liu
Leyong Wang
Zhouyu Wang
Wanhua Wu
Cheng Yang
Recent advances in chirality sensing/recognition using supramolecular macrocycles
Supramolecular Materials
Supramolecular macrocycles
Chirality sensing
Chiral sensors
Non-covalent interaction
Enantioselective recognition
title Recent advances in chirality sensing/recognition using supramolecular macrocycles
title_full Recent advances in chirality sensing/recognition using supramolecular macrocycles
title_fullStr Recent advances in chirality sensing/recognition using supramolecular macrocycles
title_full_unstemmed Recent advances in chirality sensing/recognition using supramolecular macrocycles
title_short Recent advances in chirality sensing/recognition using supramolecular macrocycles
title_sort recent advances in chirality sensing recognition using supramolecular macrocycles
topic Supramolecular macrocycles
Chirality sensing
Chiral sensors
Non-covalent interaction
Enantioselective recognition
url http://www.sciencedirect.com/science/article/pii/S2667240525000169
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AT zhouyuwang recentadvancesinchiralitysensingrecognitionusingsupramolecularmacrocycles
AT wanhuawu recentadvancesinchiralitysensingrecognitionusingsupramolecularmacrocycles
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