Recent Updates on Induced Pluripotent Stem Cells in Hematological Disorders
Over the past decade, enormous progress has been made in the field of induced pluripotent stem cells (iPSCs). Patients’ somatic cells such as skin fibroblasts or blood cells can be used to generate disease-specific pluripotent stem cells, which have unlimited proliferation and can differentiate into...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2019/5171032 |
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| author | Methichit Wattanapanitch |
| author_facet | Methichit Wattanapanitch |
| author_sort | Methichit Wattanapanitch |
| collection | DOAJ |
| description | Over the past decade, enormous progress has been made in the field of induced pluripotent stem cells (iPSCs). Patients’ somatic cells such as skin fibroblasts or blood cells can be used to generate disease-specific pluripotent stem cells, which have unlimited proliferation and can differentiate into all cell types of the body. Human iPSCs offer great promises and opportunities for treatments of degenerative diseases and studying disease pathology and drug screening. So far, many iPSC-derived disease models have led to the discovery of novel pathological mechanisms as well as new drugs in the pipeline that have been tested in the iPSC-derived cells for efficacy and potential toxicities. Furthermore, recent advances in genome editing technology in combination with the iPSC technology have provided a versatile platform for studying stem cell biology and regenerative medicine. In this review, an overview of iPSCs, patient-specific iPSCs for disease modeling and drug screening, applications of iPSCs and genome editing technology in hematological disorders, remaining challenges, and future perspectives of iPSCs in hematological diseases will be discussed. |
| format | Article |
| id | doaj-art-df1df2614aba4a1db20d4d9dd5c7f4b5 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-df1df2614aba4a1db20d4d9dd5c7f4b52025-02-03T01:30:16ZengWileyStem Cells International1687-966X1687-96782019-01-01201910.1155/2019/51710325171032Recent Updates on Induced Pluripotent Stem Cells in Hematological DisordersMethichit Wattanapanitch0Siriraj Center for Regenerative Medicine, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, ThailandOver the past decade, enormous progress has been made in the field of induced pluripotent stem cells (iPSCs). Patients’ somatic cells such as skin fibroblasts or blood cells can be used to generate disease-specific pluripotent stem cells, which have unlimited proliferation and can differentiate into all cell types of the body. Human iPSCs offer great promises and opportunities for treatments of degenerative diseases and studying disease pathology and drug screening. So far, many iPSC-derived disease models have led to the discovery of novel pathological mechanisms as well as new drugs in the pipeline that have been tested in the iPSC-derived cells for efficacy and potential toxicities. Furthermore, recent advances in genome editing technology in combination with the iPSC technology have provided a versatile platform for studying stem cell biology and regenerative medicine. In this review, an overview of iPSCs, patient-specific iPSCs for disease modeling and drug screening, applications of iPSCs and genome editing technology in hematological disorders, remaining challenges, and future perspectives of iPSCs in hematological diseases will be discussed.http://dx.doi.org/10.1155/2019/5171032 |
| spellingShingle | Methichit Wattanapanitch Recent Updates on Induced Pluripotent Stem Cells in Hematological Disorders Stem Cells International |
| title | Recent Updates on Induced Pluripotent Stem Cells in Hematological Disorders |
| title_full | Recent Updates on Induced Pluripotent Stem Cells in Hematological Disorders |
| title_fullStr | Recent Updates on Induced Pluripotent Stem Cells in Hematological Disorders |
| title_full_unstemmed | Recent Updates on Induced Pluripotent Stem Cells in Hematological Disorders |
| title_short | Recent Updates on Induced Pluripotent Stem Cells in Hematological Disorders |
| title_sort | recent updates on induced pluripotent stem cells in hematological disorders |
| url | http://dx.doi.org/10.1155/2019/5171032 |
| work_keys_str_mv | AT methichitwattanapanitch recentupdatesoninducedpluripotentstemcellsinhematologicaldisorders |