Reactive Oxygen Species as Key Molecules in the Pathogenesis of Alcoholic Fatty Liver Disease and Nonalcoholic Fatty Liver Disease: Future Perspectives
Reactive oxygen species (ROS) are central to the progression of alcoholic fatty liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD). In ALD, ROS arise from alcohol metabolism (CYP2E1 and ADH/ALDH2), causing oxidative damage and fibrosis. In NAFLD, mitochondrial dysfunction, ER stress, a...
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2025-06-01
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| author | Zhiqing Zhang Hong Yang Fei Han Peng Guo |
| author_facet | Zhiqing Zhang Hong Yang Fei Han Peng Guo |
| author_sort | Zhiqing Zhang |
| collection | DOAJ |
| description | Reactive oxygen species (ROS) are central to the progression of alcoholic fatty liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD). In ALD, ROS arise from alcohol metabolism (CYP2E1 and ADH/ALDH2), causing oxidative damage and fibrosis. In NAFLD, mitochondrial dysfunction, ER stress, and lipotoxicity drive ROS overproduction due to metabolic dysregulation. Both diseases share ROS-mediated pathways, including mitochondrial/ER dysfunction, inflammation, and impaired lipid metabolism, accelerating steatosis to cirrhosis and cancer. Antioxidants, ER modulators, and lifestyle changes show therapeutic potential but require further clinical validation. Future research should leverage multi-omics and targeted therapies to optimize ROS-focused interventions for ALD and NAFLD. |
| format | Article |
| id | doaj-art-df16ce2ff9bb41b689bbc30379baacdd |
| institution | Kabale University |
| issn | 1467-3037 1467-3045 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
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| series | Current Issues in Molecular Biology |
| spelling | doaj-art-df16ce2ff9bb41b689bbc30379baacdd2025-08-20T03:26:16ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452025-06-0147646410.3390/cimb47060464Reactive Oxygen Species as Key Molecules in the Pathogenesis of Alcoholic Fatty Liver Disease and Nonalcoholic Fatty Liver Disease: Future PerspectivesZhiqing Zhang0Hong Yang1Fei Han2Peng Guo3Department of Hepatobiliary Surgery, The Third Affiliated Hospital, Chongqing Medical University, Yubei, Chongqing 401120, ChinaDepartment of Hepatobiliary Surgery, The Third Affiliated Hospital, Chongqing Medical University, Yubei, Chongqing 401120, ChinaSchool of Public Health, Chongqing Medical University, Chongqing 400016, ChinaDepartment of Hepatobiliary Surgery, The Third Affiliated Hospital, Chongqing Medical University, Yubei, Chongqing 401120, ChinaReactive oxygen species (ROS) are central to the progression of alcoholic fatty liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD). In ALD, ROS arise from alcohol metabolism (CYP2E1 and ADH/ALDH2), causing oxidative damage and fibrosis. In NAFLD, mitochondrial dysfunction, ER stress, and lipotoxicity drive ROS overproduction due to metabolic dysregulation. Both diseases share ROS-mediated pathways, including mitochondrial/ER dysfunction, inflammation, and impaired lipid metabolism, accelerating steatosis to cirrhosis and cancer. Antioxidants, ER modulators, and lifestyle changes show therapeutic potential but require further clinical validation. Future research should leverage multi-omics and targeted therapies to optimize ROS-focused interventions for ALD and NAFLD.https://www.mdpi.com/1467-3045/47/6/464reactive oxygen speciesalcoholic fatty liver diseasenonalcoholic fatty liver disease |
| spellingShingle | Zhiqing Zhang Hong Yang Fei Han Peng Guo Reactive Oxygen Species as Key Molecules in the Pathogenesis of Alcoholic Fatty Liver Disease and Nonalcoholic Fatty Liver Disease: Future Perspectives Current Issues in Molecular Biology reactive oxygen species alcoholic fatty liver disease nonalcoholic fatty liver disease |
| title | Reactive Oxygen Species as Key Molecules in the Pathogenesis of Alcoholic Fatty Liver Disease and Nonalcoholic Fatty Liver Disease: Future Perspectives |
| title_full | Reactive Oxygen Species as Key Molecules in the Pathogenesis of Alcoholic Fatty Liver Disease and Nonalcoholic Fatty Liver Disease: Future Perspectives |
| title_fullStr | Reactive Oxygen Species as Key Molecules in the Pathogenesis of Alcoholic Fatty Liver Disease and Nonalcoholic Fatty Liver Disease: Future Perspectives |
| title_full_unstemmed | Reactive Oxygen Species as Key Molecules in the Pathogenesis of Alcoholic Fatty Liver Disease and Nonalcoholic Fatty Liver Disease: Future Perspectives |
| title_short | Reactive Oxygen Species as Key Molecules in the Pathogenesis of Alcoholic Fatty Liver Disease and Nonalcoholic Fatty Liver Disease: Future Perspectives |
| title_sort | reactive oxygen species as key molecules in the pathogenesis of alcoholic fatty liver disease and nonalcoholic fatty liver disease future perspectives |
| topic | reactive oxygen species alcoholic fatty liver disease nonalcoholic fatty liver disease |
| url | https://www.mdpi.com/1467-3045/47/6/464 |
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