Effective Treatment of Rheumatoid Arthritis-Associated Interstitial Lung Disease by B-Cell Targeted Therapy with Rituximab
Rheumatoid arthritis- (RA-) associated interstitial lung disease (RA-ILD) is the extra-articular complication with most adverse impact on the quality of life and survival in RA patients. However, treatment options are limited and controlled studies are lacking. Here, we present the case of a 66-yea...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/272303 |
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| author | Wolfgang Hartung Judith Maier Michael Pfeifer Martin Fleck |
| author_facet | Wolfgang Hartung Judith Maier Michael Pfeifer Martin Fleck |
| author_sort | Wolfgang Hartung |
| collection | DOAJ |
| description | Rheumatoid arthritis- (RA-) associated interstitial lung disease (RA-ILD) is the extra-articular complication with most adverse impact on the quality of life and survival in RA patients. However, treatment options are limited and controlled studies are lacking. Here, we present the case of a 66-year-old patient suffering from severe RA-ILD, which has been successfully treated with Rituximab (RTX). After failure of conventional DMARD therapy, our patient showed sustained improvement of clinical pulmonary parameters as well as joint inflammation following B-cell depletion with RTX. The six-minute-walk test improved from 380 meters to 536 meters and the forced vital capacity from 2.49 liters to 3.49. The disease activity score could be reduced from 7.7 to 2.8. Therefore, RTX might be considered as an alternative treatment for RA-ILD in patients not responding to conventional DMARD therapy. |
| format | Article |
| id | doaj-art-df14d9d3bcb44f3499a01fe7b8b62010 |
| institution | OA Journals |
| issn | 2090-6609 2090-6617 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Immunology |
| spelling | doaj-art-df14d9d3bcb44f3499a01fe7b8b620102025-08-20T02:21:06ZengWileyCase Reports in Immunology2090-66092090-66172012-01-01201210.1155/2012/272303272303Effective Treatment of Rheumatoid Arthritis-Associated Interstitial Lung Disease by B-Cell Targeted Therapy with RituximabWolfgang Hartung0Judith Maier1Michael Pfeifer2Martin Fleck3Department of Rheumatology and Clinical Immunology, Asklepios Clinic, 93077 Bad Abbach, GermanyDepartment of Internal Medicine I, University of Regensburg, 93042 Regensburg, GermanyDepartment of Pulmonology and Internal Medicine II, University of Regensburg, 93042 Regensburg, GermanyDepartment of Rheumatology and Clinical Immunology, Asklepios Clinic, 93077 Bad Abbach, GermanyRheumatoid arthritis- (RA-) associated interstitial lung disease (RA-ILD) is the extra-articular complication with most adverse impact on the quality of life and survival in RA patients. However, treatment options are limited and controlled studies are lacking. Here, we present the case of a 66-year-old patient suffering from severe RA-ILD, which has been successfully treated with Rituximab (RTX). After failure of conventional DMARD therapy, our patient showed sustained improvement of clinical pulmonary parameters as well as joint inflammation following B-cell depletion with RTX. The six-minute-walk test improved from 380 meters to 536 meters and the forced vital capacity from 2.49 liters to 3.49. The disease activity score could be reduced from 7.7 to 2.8. Therefore, RTX might be considered as an alternative treatment for RA-ILD in patients not responding to conventional DMARD therapy.http://dx.doi.org/10.1155/2012/272303 |
| spellingShingle | Wolfgang Hartung Judith Maier Michael Pfeifer Martin Fleck Effective Treatment of Rheumatoid Arthritis-Associated Interstitial Lung Disease by B-Cell Targeted Therapy with Rituximab Case Reports in Immunology |
| title | Effective Treatment of Rheumatoid Arthritis-Associated Interstitial Lung Disease by B-Cell Targeted Therapy with Rituximab |
| title_full | Effective Treatment of Rheumatoid Arthritis-Associated Interstitial Lung Disease by B-Cell Targeted Therapy with Rituximab |
| title_fullStr | Effective Treatment of Rheumatoid Arthritis-Associated Interstitial Lung Disease by B-Cell Targeted Therapy with Rituximab |
| title_full_unstemmed | Effective Treatment of Rheumatoid Arthritis-Associated Interstitial Lung Disease by B-Cell Targeted Therapy with Rituximab |
| title_short | Effective Treatment of Rheumatoid Arthritis-Associated Interstitial Lung Disease by B-Cell Targeted Therapy with Rituximab |
| title_sort | effective treatment of rheumatoid arthritis associated interstitial lung disease by b cell targeted therapy with rituximab |
| url | http://dx.doi.org/10.1155/2012/272303 |
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