Bilateral Ampiginous Choroiditis following Presumed SARS-CoV-2 Infection

Purpose. To report a case of bilateral ampiginous choroiditis following presumed SARS-CoV-2 infection. Case Description. A 25-year-old woman presented with metamorphopsia and a paracentral scotoma in her left eye. She endorsed night sweats, headache, and new-onset anosmia beginning 1 week before her...

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Main Authors: Elysse S. Tom, K. Matthew McKay, Steven S. Saraf
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Case Reports in Ophthalmological Medicine
Online Access:http://dx.doi.org/10.1155/2021/1646364
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author Elysse S. Tom
K. Matthew McKay
Steven S. Saraf
author_facet Elysse S. Tom
K. Matthew McKay
Steven S. Saraf
author_sort Elysse S. Tom
collection DOAJ
description Purpose. To report a case of bilateral ampiginous choroiditis following presumed SARS-CoV-2 infection. Case Description. A 25-year-old woman presented with metamorphopsia and a paracentral scotoma in her left eye. She endorsed night sweats, headache, and new-onset anosmia beginning 1 week before her visual symptoms. She also had multiple confirmed ill COVID-19 contacts at her workplace before the onset of her symptoms. Funduscopic examination and multimodal imaging revealed placoid lesions in the macula and midperiphery of both eyes consistent with ampiginous choroiditis. COVID-19 antibody testing returned positive for IgG, and an extensive systemic evaluation was otherwise unremarkable. She was treated with oral prednisone and azathioprine with stabilization of the retinal lesions and no progression of her symptoms. Conclusions. Ampiginous choroiditis is an inflammatory chorioretinopathy with an unknown pathogenic mechanism that often necessitates early immunomodulatory therapy. This report suggests that SARS-CoV-2 infection may trigger chorioretinal inflammation in susceptible hosts.
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spelling doaj-art-df0c4b5a5bde4ab6a3aa9e2abd7e32a92025-02-03T05:44:44ZengWileyCase Reports in Ophthalmological Medicine2090-67222090-67302021-01-01202110.1155/2021/16463641646364Bilateral Ampiginous Choroiditis following Presumed SARS-CoV-2 InfectionElysse S. Tom0K. Matthew McKay1Steven S. Saraf2Department of Ophthalmology, University of Washington, Seattle, WA, USADepartment of Ophthalmology, University of Washington, Seattle, WA, USADepartment of Ophthalmology, University of Washington, Seattle, WA, USAPurpose. To report a case of bilateral ampiginous choroiditis following presumed SARS-CoV-2 infection. Case Description. A 25-year-old woman presented with metamorphopsia and a paracentral scotoma in her left eye. She endorsed night sweats, headache, and new-onset anosmia beginning 1 week before her visual symptoms. She also had multiple confirmed ill COVID-19 contacts at her workplace before the onset of her symptoms. Funduscopic examination and multimodal imaging revealed placoid lesions in the macula and midperiphery of both eyes consistent with ampiginous choroiditis. COVID-19 antibody testing returned positive for IgG, and an extensive systemic evaluation was otherwise unremarkable. She was treated with oral prednisone and azathioprine with stabilization of the retinal lesions and no progression of her symptoms. Conclusions. Ampiginous choroiditis is an inflammatory chorioretinopathy with an unknown pathogenic mechanism that often necessitates early immunomodulatory therapy. This report suggests that SARS-CoV-2 infection may trigger chorioretinal inflammation in susceptible hosts.http://dx.doi.org/10.1155/2021/1646364
spellingShingle Elysse S. Tom
K. Matthew McKay
Steven S. Saraf
Bilateral Ampiginous Choroiditis following Presumed SARS-CoV-2 Infection
Case Reports in Ophthalmological Medicine
title Bilateral Ampiginous Choroiditis following Presumed SARS-CoV-2 Infection
title_full Bilateral Ampiginous Choroiditis following Presumed SARS-CoV-2 Infection
title_fullStr Bilateral Ampiginous Choroiditis following Presumed SARS-CoV-2 Infection
title_full_unstemmed Bilateral Ampiginous Choroiditis following Presumed SARS-CoV-2 Infection
title_short Bilateral Ampiginous Choroiditis following Presumed SARS-CoV-2 Infection
title_sort bilateral ampiginous choroiditis following presumed sars cov 2 infection
url http://dx.doi.org/10.1155/2021/1646364
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