Fucofuroeckol-A from Eisenia bicyclis Inhibits Inflammation in Lipopolysaccharide-Induced Mouse Macrophages via Downregulation of the MAPK/NF-κB Signaling Pathway
Fucofuroeckol-A (FF) isolated from an edible perennial brown seaweed Eisenia bicyclis was shown to be potent anti-inflammatory agents. FF suppressed the production of nitric oxide (NO) and prostaglandin E2 (PGE2) and the expression of inducible nitric oxide synthase and cyclooxygenase-2 dose depende...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2016/6509212 |
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| author | Sang-Hoon Lee Sung-Hwan Eom Na-Young Yoon Moon-Moo Kim Yong-Xin Li Sang Keun Ha Se-Kwon Kim |
| author_facet | Sang-Hoon Lee Sung-Hwan Eom Na-Young Yoon Moon-Moo Kim Yong-Xin Li Sang Keun Ha Se-Kwon Kim |
| author_sort | Sang-Hoon Lee |
| collection | DOAJ |
| description | Fucofuroeckol-A (FF) isolated from an edible perennial brown seaweed Eisenia bicyclis was shown to be potent anti-inflammatory agents. FF suppressed the production of nitric oxide (NO) and prostaglandin E2 (PGE2) and the expression of inducible nitric oxide synthase and cyclooxygenase-2 dose dependently in lipopolysaccharide- (LPS-) induced RAW 264.7 mouse macrophages. An enzyme-linked immunosorbent assay and cytometric bead array assay demonstrated that FF significantly reduced the production of proinflammatory cytokines, such as interleukin-6 and tumor necrosis factor-α, and that of the monocyte chemoattractant protein-1. Moreover, FF reduced the activation of nuclear factor κB (NF-κB) and mitogen-activated protein kinases (MAPKs). These results strongly suggest that the inhibitory effects of fucofuroeckol-A from E. bicyclis on LPS-induced NO and PGE2 production might be due to the suppression of the NF-κB and MAPK signaling pathway. |
| format | Article |
| id | doaj-art-df0b88af29b3439b8d78653cf6a838c9 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-df0b88af29b3439b8d78653cf6a838c92025-02-03T06:42:14ZengWileyJournal of Chemistry2090-90632090-90712016-01-01201610.1155/2016/65092126509212Fucofuroeckol-A from Eisenia bicyclis Inhibits Inflammation in Lipopolysaccharide-Induced Mouse Macrophages via Downregulation of the MAPK/NF-κB Signaling PathwaySang-Hoon Lee0Sung-Hwan Eom1Na-Young Yoon2Moon-Moo Kim3Yong-Xin Li4Sang Keun Ha5Se-Kwon Kim6Korea Food Research Institute, Baekhyun-dong, Seongnam, Gyeonggi 13539, Republic of KoreaKorea Food Research Institute, Baekhyun-dong, Seongnam, Gyeonggi 13539, Republic of KoreaFood and Safety Research Center, National Fisheries Research & Development, Busan 46083, Republic of KoreaDepartment of Chemistry, Dong-Eui University, Busan 47340, Republic of KoreaMarine Bioprocess Research Center, Pukyong National University, Busan 48513, Republic of KoreaKorea Food Research Institute, Baekhyun-dong, Seongnam, Gyeonggi 13539, Republic of KoreaMarine Bioprocess Research Center, Pukyong National University, Busan 48513, Republic of KoreaFucofuroeckol-A (FF) isolated from an edible perennial brown seaweed Eisenia bicyclis was shown to be potent anti-inflammatory agents. FF suppressed the production of nitric oxide (NO) and prostaglandin E2 (PGE2) and the expression of inducible nitric oxide synthase and cyclooxygenase-2 dose dependently in lipopolysaccharide- (LPS-) induced RAW 264.7 mouse macrophages. An enzyme-linked immunosorbent assay and cytometric bead array assay demonstrated that FF significantly reduced the production of proinflammatory cytokines, such as interleukin-6 and tumor necrosis factor-α, and that of the monocyte chemoattractant protein-1. Moreover, FF reduced the activation of nuclear factor κB (NF-κB) and mitogen-activated protein kinases (MAPKs). These results strongly suggest that the inhibitory effects of fucofuroeckol-A from E. bicyclis on LPS-induced NO and PGE2 production might be due to the suppression of the NF-κB and MAPK signaling pathway.http://dx.doi.org/10.1155/2016/6509212 |
| spellingShingle | Sang-Hoon Lee Sung-Hwan Eom Na-Young Yoon Moon-Moo Kim Yong-Xin Li Sang Keun Ha Se-Kwon Kim Fucofuroeckol-A from Eisenia bicyclis Inhibits Inflammation in Lipopolysaccharide-Induced Mouse Macrophages via Downregulation of the MAPK/NF-κB Signaling Pathway Journal of Chemistry |
| title | Fucofuroeckol-A from Eisenia bicyclis Inhibits Inflammation in Lipopolysaccharide-Induced Mouse Macrophages via Downregulation of the MAPK/NF-κB Signaling Pathway |
| title_full | Fucofuroeckol-A from Eisenia bicyclis Inhibits Inflammation in Lipopolysaccharide-Induced Mouse Macrophages via Downregulation of the MAPK/NF-κB Signaling Pathway |
| title_fullStr | Fucofuroeckol-A from Eisenia bicyclis Inhibits Inflammation in Lipopolysaccharide-Induced Mouse Macrophages via Downregulation of the MAPK/NF-κB Signaling Pathway |
| title_full_unstemmed | Fucofuroeckol-A from Eisenia bicyclis Inhibits Inflammation in Lipopolysaccharide-Induced Mouse Macrophages via Downregulation of the MAPK/NF-κB Signaling Pathway |
| title_short | Fucofuroeckol-A from Eisenia bicyclis Inhibits Inflammation in Lipopolysaccharide-Induced Mouse Macrophages via Downregulation of the MAPK/NF-κB Signaling Pathway |
| title_sort | fucofuroeckol a from eisenia bicyclis inhibits inflammation in lipopolysaccharide induced mouse macrophages via downregulation of the mapk nf κb signaling pathway |
| url | http://dx.doi.org/10.1155/2016/6509212 |
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