Comparative analysis of bioaccessibility tests for metals and metalloids: Methodological advancements and implications for consumer product safety
Bioaccessibility is crucial in human health risk assessment as it predicts the fraction of metals and metalloids absorbed by the human body. This study compared the modified RIVM method, which includes acid digestion, with the ERU 19899 EN method to assess the oral bioaccessibility of certified refe...
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Elsevier
2025-02-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325001770 |
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| author | Buyun Jeong Dong-Jun Baek Haeun Kim Seon-Woo Kwon Jung-Hwan Kwon Jinsung An |
| author_facet | Buyun Jeong Dong-Jun Baek Haeun Kim Seon-Woo Kwon Jung-Hwan Kwon Jinsung An |
| author_sort | Buyun Jeong |
| collection | DOAJ |
| description | Bioaccessibility is crucial in human health risk assessment as it predicts the fraction of metals and metalloids absorbed by the human body. This study compared the modified RIVM method, which includes acid digestion, with the ERU 19899 EN method to assess the oral bioaccessibility of certified reference materials. The modified RIVM method showed higher bioaccessibility, offering more conservative health risk values. Adding a filtration step after centrifugation with a 0.45 μm filter reduced the error in the results from 66.7 % to 19.9 % by removing small particles that were not separated during centrifugation. Dermal bioaccessibility was evaluated using two artificial sweat solutions: one with five amino acids at pH 5.5 and the EN 1811 method at pH 6.5. The pH 5.5 solution leached more metals due to complexation between amino acids and metal ions, increasing solubility. Sebum decreased the leached amount of cationic metals (Cd, Cr, and Pb), as fatty acids can form complexes with metal ions. Therefore, a solution with five amino acids at pH 5.5, without sebum, is suggested for assessing dermal bioaccessibility. Various consumer products, including seven toys, were tested for both oral and dermal bioaccessibility to provide more reliable health risk assessment information. The oral bioaccessibility results of the toys aligned with other studies. The dermal bioaccessibility of the consumer products ranged from 0.001 % to 1.414 %, with the highest Cr concentration measured in a brown watch strap. |
| format | Article |
| id | doaj-art-df07e9b7deba4eaaabf50f726c17610d |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-df07e9b7deba4eaaabf50f726c17610d2025-02-05T04:31:04ZengElsevierEcotoxicology and Environmental Safety0147-65132025-02-01291117841Comparative analysis of bioaccessibility tests for metals and metalloids: Methodological advancements and implications for consumer product safetyBuyun Jeong0Dong-Jun Baek1Haeun Kim2Seon-Woo Kwon3Jung-Hwan Kwon4Jinsung An5Department of Civil & Environmental Engineering, Seoul National University, Seoul 08826, South KoreaDepartment of Smart City Engineering, Hanyang University, Ansan 15588, South KoreaDepartment of Smart City Engineering, Hanyang University, Ansan 15588, South KoreaDepartment of Environment Safety System Engineering, Semyung University, Jecheon 27136, South KoreaDivision of Environmental Science and Ecological Engineering, Korea University, Seoul 02841, South KoreaDepartment of Smart City Engineering, Hanyang University, Ansan 15588, South Korea; Department of Civil and Environmental Engineering, Hanyang University, Ansan 15588, South Korea; Corresponding author at: Department of Smart City Engineering, Hanyang University, Ansan 15588, South Korea.Bioaccessibility is crucial in human health risk assessment as it predicts the fraction of metals and metalloids absorbed by the human body. This study compared the modified RIVM method, which includes acid digestion, with the ERU 19899 EN method to assess the oral bioaccessibility of certified reference materials. The modified RIVM method showed higher bioaccessibility, offering more conservative health risk values. Adding a filtration step after centrifugation with a 0.45 μm filter reduced the error in the results from 66.7 % to 19.9 % by removing small particles that were not separated during centrifugation. Dermal bioaccessibility was evaluated using two artificial sweat solutions: one with five amino acids at pH 5.5 and the EN 1811 method at pH 6.5. The pH 5.5 solution leached more metals due to complexation between amino acids and metal ions, increasing solubility. Sebum decreased the leached amount of cationic metals (Cd, Cr, and Pb), as fatty acids can form complexes with metal ions. Therefore, a solution with five amino acids at pH 5.5, without sebum, is suggested for assessing dermal bioaccessibility. Various consumer products, including seven toys, were tested for both oral and dermal bioaccessibility to provide more reliable health risk assessment information. The oral bioaccessibility results of the toys aligned with other studies. The dermal bioaccessibility of the consumer products ranged from 0.001 % to 1.414 %, with the highest Cr concentration measured in a brown watch strap.http://www.sciencedirect.com/science/article/pii/S0147651325001770MigrationBioaccessibilityConsumer productsArtificial digestive juicesArtificial sweatArtificial sebum |
| spellingShingle | Buyun Jeong Dong-Jun Baek Haeun Kim Seon-Woo Kwon Jung-Hwan Kwon Jinsung An Comparative analysis of bioaccessibility tests for metals and metalloids: Methodological advancements and implications for consumer product safety Ecotoxicology and Environmental Safety Migration Bioaccessibility Consumer products Artificial digestive juices Artificial sweat Artificial sebum |
| title | Comparative analysis of bioaccessibility tests for metals and metalloids: Methodological advancements and implications for consumer product safety |
| title_full | Comparative analysis of bioaccessibility tests for metals and metalloids: Methodological advancements and implications for consumer product safety |
| title_fullStr | Comparative analysis of bioaccessibility tests for metals and metalloids: Methodological advancements and implications for consumer product safety |
| title_full_unstemmed | Comparative analysis of bioaccessibility tests for metals and metalloids: Methodological advancements and implications for consumer product safety |
| title_short | Comparative analysis of bioaccessibility tests for metals and metalloids: Methodological advancements and implications for consumer product safety |
| title_sort | comparative analysis of bioaccessibility tests for metals and metalloids methodological advancements and implications for consumer product safety |
| topic | Migration Bioaccessibility Consumer products Artificial digestive juices Artificial sweat Artificial sebum |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325001770 |
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