Ferroptosis: A novel cell death modality as a synergistic therapeutic strategy with photodynamic therapy
Although there has been significant progress in current comprehensive anticancer treatments centered on surgery, postoperative recurrence and tumor metastasis still significantly affect both prognosis and quality of life of the patient. Hence, the development of precisely targeted tumor therapies an...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S157210002400499X |
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| author | Yuqing Wang Yiting Xu Yong Qu Yifang Jin Juanmei Cao Jinshan Zhan Zhuoxia Li Chuxing Chai Changzheng Huang Min Li |
| author_facet | Yuqing Wang Yiting Xu Yong Qu Yifang Jin Juanmei Cao Jinshan Zhan Zhuoxia Li Chuxing Chai Changzheng Huang Min Li |
| author_sort | Yuqing Wang |
| collection | DOAJ |
| description | Although there has been significant progress in current comprehensive anticancer treatments centered on surgery, postoperative recurrence and tumor metastasis still significantly affect both prognosis and quality of life of the patient. Hence, the development of precisely targeted tumor therapies and exploration of immunotherapy represent additional strategies for tumor treatment. Photodynamic therapy (PDT) is a relatively safe treatment modality that not only induces multiple modes of tumor cell death but also mediates the secondary immunological responses against tumor resistance and metastasis. Ferroptosis, an iron-dependent type of programmed cell death characterized by accumulation of reactive oxygen species and lipid peroxidation products to lethal levels, has emerged as an attractive target trigger for tumor therapies. Recent research has revealed a close association between PDT and ferroptosis, suggesting that combining ferroptosis inducers with PDT could strengthen their synergistic anti-tumor efficiency. Here in this review, we discuss the rationale for combining PDT with ferroptosis inducers and highlight the progress of single-molecule photosensitizers to induce ferroptosis, as well as the applications of photosensitizers combined with other therapeutic drugs for collaborative therapy. Furthermore, given the current research dilemma, we propose potential therapeutic strategies to advance the combined usage of PDT and ferroptosis inducers, providing the basis and guidelines for prospective clinical translation and research directionality with regard to PDT. |
| format | Article |
| id | doaj-art-defe79cebeea42c0b8eb3562b961299b |
| institution | Kabale University |
| issn | 1572-1000 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-defe79cebeea42c0b8eb3562b961299b2025-02-01T04:11:47ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002025-02-0151104463Ferroptosis: A novel cell death modality as a synergistic therapeutic strategy with photodynamic therapyYuqing Wang0Yiting Xu1Yong Qu2Yifang Jin3Juanmei Cao4Jinshan Zhan5Zhuoxia Li6Chuxing Chai7Changzheng Huang8Min Li9Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaCentral Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Department of Dermatology, First Affiliated Hospital, Shihezi University, Shihezi 832008, ChinaDepartment of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Corresponding authors.Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Corresponding authors.Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Corresponding authors.Although there has been significant progress in current comprehensive anticancer treatments centered on surgery, postoperative recurrence and tumor metastasis still significantly affect both prognosis and quality of life of the patient. Hence, the development of precisely targeted tumor therapies and exploration of immunotherapy represent additional strategies for tumor treatment. Photodynamic therapy (PDT) is a relatively safe treatment modality that not only induces multiple modes of tumor cell death but also mediates the secondary immunological responses against tumor resistance and metastasis. Ferroptosis, an iron-dependent type of programmed cell death characterized by accumulation of reactive oxygen species and lipid peroxidation products to lethal levels, has emerged as an attractive target trigger for tumor therapies. Recent research has revealed a close association between PDT and ferroptosis, suggesting that combining ferroptosis inducers with PDT could strengthen their synergistic anti-tumor efficiency. Here in this review, we discuss the rationale for combining PDT with ferroptosis inducers and highlight the progress of single-molecule photosensitizers to induce ferroptosis, as well as the applications of photosensitizers combined with other therapeutic drugs for collaborative therapy. Furthermore, given the current research dilemma, we propose potential therapeutic strategies to advance the combined usage of PDT and ferroptosis inducers, providing the basis and guidelines for prospective clinical translation and research directionality with regard to PDT.http://www.sciencedirect.com/science/article/pii/S157210002400499XFerroptosisPhotodynamic therapyPhotosensitizerAggregation-induced emissionSynergistic anti-tumor therapy |
| spellingShingle | Yuqing Wang Yiting Xu Yong Qu Yifang Jin Juanmei Cao Jinshan Zhan Zhuoxia Li Chuxing Chai Changzheng Huang Min Li Ferroptosis: A novel cell death modality as a synergistic therapeutic strategy with photodynamic therapy Photodiagnosis and Photodynamic Therapy Ferroptosis Photodynamic therapy Photosensitizer Aggregation-induced emission Synergistic anti-tumor therapy |
| title | Ferroptosis: A novel cell death modality as a synergistic therapeutic strategy with photodynamic therapy |
| title_full | Ferroptosis: A novel cell death modality as a synergistic therapeutic strategy with photodynamic therapy |
| title_fullStr | Ferroptosis: A novel cell death modality as a synergistic therapeutic strategy with photodynamic therapy |
| title_full_unstemmed | Ferroptosis: A novel cell death modality as a synergistic therapeutic strategy with photodynamic therapy |
| title_short | Ferroptosis: A novel cell death modality as a synergistic therapeutic strategy with photodynamic therapy |
| title_sort | ferroptosis a novel cell death modality as a synergistic therapeutic strategy with photodynamic therapy |
| topic | Ferroptosis Photodynamic therapy Photosensitizer Aggregation-induced emission Synergistic anti-tumor therapy |
| url | http://www.sciencedirect.com/science/article/pii/S157210002400499X |
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