MOLECULAR GENETIC STUDIES OF COMORBIDITY
This review focuses at the problem of the genetic basis of comorbidity. We discuss the concepts and terms relating to combinations of diseases. The guidelines of the study of comorbidity using modern high throughput methods and approaches of genetics, molecular biology and bioinformatics are designa...
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2015-12-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/385 |
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| _version_ | 1849689260625494016 |
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| author | Ye. Yu. Bragina M. B. Freidin |
| author_facet | Ye. Yu. Bragina M. B. Freidin |
| author_sort | Ye. Yu. Bragina |
| collection | DOAJ |
| description | This review focuses at the problem of the genetic basis of comorbidity. We discuss the concepts and terms relating to combinations of diseases. The guidelines of the study of comorbidity using modern high throughput methods and approaches of genetics, molecular biology and bioinformatics are designated. In this review we present results of studies showing genetic specificity for the combined phenotypes dif-ferent from the isolated disease, we considergene-gene and gene-environment interactions in comorbidity. We also discuss the role of single nucleotide polymorphisms and structural genome variations in the development of comorbidity. Own results of researching shared genes of inversely comorbid diseases like as bronchial asthma and tuberculosis are presented. |
| format | Article |
| id | doaj-art-deeb91c712154fdd91256b59cd921c84 |
| institution | DOAJ |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2015-12-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-deeb91c712154fdd91256b59cd921c842025-08-20T03:21:42ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842015-12-011469410210.20538/1682-0363-2015-6-94-102371MOLECULAR GENETIC STUDIES OF COMORBIDITYYe. Yu. Bragina0M. B. Freidin1Research Institute for Medical Genetics, Tomsk, Russian FederationResearch Institute for Medical Genetics, Tomsk, Russian FederationThis review focuses at the problem of the genetic basis of comorbidity. We discuss the concepts and terms relating to combinations of diseases. The guidelines of the study of comorbidity using modern high throughput methods and approaches of genetics, molecular biology and bioinformatics are designated. In this review we present results of studies showing genetic specificity for the combined phenotypes dif-ferent from the isolated disease, we considergene-gene and gene-environment interactions in comorbidity. We also discuss the role of single nucleotide polymorphisms and structural genome variations in the development of comorbidity. Own results of researching shared genes of inversely comorbid diseases like as bronchial asthma and tuberculosis are presented.https://bulletin.ssmu.ru/jour/article/view/385comorbiditysyntropydystropygenes |
| spellingShingle | Ye. Yu. Bragina M. B. Freidin MOLECULAR GENETIC STUDIES OF COMORBIDITY Бюллетень сибирской медицины comorbidity syntropy dystropy genes |
| title | MOLECULAR GENETIC STUDIES OF COMORBIDITY |
| title_full | MOLECULAR GENETIC STUDIES OF COMORBIDITY |
| title_fullStr | MOLECULAR GENETIC STUDIES OF COMORBIDITY |
| title_full_unstemmed | MOLECULAR GENETIC STUDIES OF COMORBIDITY |
| title_short | MOLECULAR GENETIC STUDIES OF COMORBIDITY |
| title_sort | molecular genetic studies of comorbidity |
| topic | comorbidity syntropy dystropy genes |
| url | https://bulletin.ssmu.ru/jour/article/view/385 |
| work_keys_str_mv | AT yeyubragina moleculargeneticstudiesofcomorbidity AT mbfreidin moleculargeneticstudiesofcomorbidity |