Effect of exercise intervention on health-related quality of life in middle-aged and older people with osteoporosis: a systematic review and meta-analysis
Background Osteoporosis is a common condition affecting middle-aged and older people, posing a serious threat to their health-related quality of life (HRQOL). In recent years, multiple studies have investigated the impact of exercise interventions on HRQOL in middle-aged and older individuals with o...
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| description | Background Osteoporosis is a common condition affecting middle-aged and older people, posing a serious threat to their health-related quality of life (HRQOL). In recent years, multiple studies have investigated the impact of exercise interventions on HRQOL in middle-aged and older individuals with osteoporosis, but the conclusions have been inconsistent. The aim of this study was to determine the true significance of exercise interventions on HRQOL in middle-aged and older individuals with osteoporosis and to identify optimal exercise prescriptions. Methods Six databases were searched for RCTs on the impact of exercise interventions on HRQOL in middle-aged and older individuals with osteoporosis. The methodological quality of the study was evaluated with Cochrane risk assessment tool. The effect size pooling, heterogeneity testing, and publication bias were analyzed using Review Manager 5.4 software. Result A total of 14 RCTs involving 1,214 participants were included, published between 2007 and 2022. The pooled results demonstrated that exercise interventions significantly improved general HRQOL (SMD = 0.79, 95% CI [0.34–1.24], p = 0.0006). In terms of physical HRQOL, significant improvements were observed in bodily pain (SMD = 0.51, 95% CI [0.24–0.78], p= 0.0002), physical function (SMD = 0.56, 95% CI [0.21–0.91], p = 0.002), role physical (SMD = 0.39, 95% CI [0.14–0.64], p = 0.003), and general health (SMD = 0.68, 95% CI [0.25–1.11], p = 0.002). Regarding mental HRQOL, significant improvements were found in vitality (SMD = 0.58, 95% CI [0.15–1.01], p = 0.008), social function (SMD = 0.37, 95% CI [0.17–0.58], p = 0.0004), and mental health (SMD = 0.50, 95% CI [0.25–0.74], p < 0.0001). Subgroup analysis results indicated that resistance training (SMD = 1.01, 95% CI [0.50–1.52], p = 0.0001), intervention frequency of at least three times per week (SMD = 0.80, 95% CI [0.22–1.38], p = 0.007), and intervention duration of 13–24 weeks (SMD = 0.85, 95% CI [0.37–1.33], p = 0.0005) had large and significant effects on general HRQOL improvements. Conclusion Exercise interventions improved HRQOL in middle-aged and older individuals with osteoporosis. Resistance training has shown greater benefits than mixed exercises. The optimal frequency is at least three per week, yielding the greatest improvement. Exercise interventions lasting 13–24 weeks had the most pronounced effect compared to other durations. Registration PROSPERO (No. CRD42023438771). |
| format | Article |
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| institution | Kabale University |
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| spelling | doaj-art-dee761d1f93d45c89a47ae802cc581e62025-02-02T15:05:13ZengPeerJ Inc.PeerJ2167-83592025-01-0113e1888910.7717/peerj.18889Effect of exercise intervention on health-related quality of life in middle-aged and older people with osteoporosis: a systematic review and meta-analysisDi Geng0Xiaogang Li1Yan Shi2Department of Physical Education, University of Electronic Science and Technology of China, Chengdu, ChinaSchool of Physical Education, Sichuan Normal University, Chengdu, ChinaPostdoctoral Research Station in Sports Science, Shanxi University, Taiyuan, ChinaBackground Osteoporosis is a common condition affecting middle-aged and older people, posing a serious threat to their health-related quality of life (HRQOL). In recent years, multiple studies have investigated the impact of exercise interventions on HRQOL in middle-aged and older individuals with osteoporosis, but the conclusions have been inconsistent. The aim of this study was to determine the true significance of exercise interventions on HRQOL in middle-aged and older individuals with osteoporosis and to identify optimal exercise prescriptions. Methods Six databases were searched for RCTs on the impact of exercise interventions on HRQOL in middle-aged and older individuals with osteoporosis. The methodological quality of the study was evaluated with Cochrane risk assessment tool. The effect size pooling, heterogeneity testing, and publication bias were analyzed using Review Manager 5.4 software. Result A total of 14 RCTs involving 1,214 participants were included, published between 2007 and 2022. The pooled results demonstrated that exercise interventions significantly improved general HRQOL (SMD = 0.79, 95% CI [0.34–1.24], p = 0.0006). In terms of physical HRQOL, significant improvements were observed in bodily pain (SMD = 0.51, 95% CI [0.24–0.78], p= 0.0002), physical function (SMD = 0.56, 95% CI [0.21–0.91], p = 0.002), role physical (SMD = 0.39, 95% CI [0.14–0.64], p = 0.003), and general health (SMD = 0.68, 95% CI [0.25–1.11], p = 0.002). Regarding mental HRQOL, significant improvements were found in vitality (SMD = 0.58, 95% CI [0.15–1.01], p = 0.008), social function (SMD = 0.37, 95% CI [0.17–0.58], p = 0.0004), and mental health (SMD = 0.50, 95% CI [0.25–0.74], p < 0.0001). Subgroup analysis results indicated that resistance training (SMD = 1.01, 95% CI [0.50–1.52], p = 0.0001), intervention frequency of at least three times per week (SMD = 0.80, 95% CI [0.22–1.38], p = 0.007), and intervention duration of 13–24 weeks (SMD = 0.85, 95% CI [0.37–1.33], p = 0.0005) had large and significant effects on general HRQOL improvements. Conclusion Exercise interventions improved HRQOL in middle-aged and older individuals with osteoporosis. Resistance training has shown greater benefits than mixed exercises. The optimal frequency is at least three per week, yielding the greatest improvement. Exercise interventions lasting 13–24 weeks had the most pronounced effect compared to other durations. Registration PROSPERO (No. CRD42023438771).https://peerj.com/articles/18889.pdfPhysical exerciseHealth-related quality of lifeOsteoporosisMiddle-aged peopleOlder people |
| spellingShingle | Di Geng Xiaogang Li Yan Shi Effect of exercise intervention on health-related quality of life in middle-aged and older people with osteoporosis: a systematic review and meta-analysis PeerJ Physical exercise Health-related quality of life Osteoporosis Middle-aged people Older people |
| title | Effect of exercise intervention on health-related quality of life in middle-aged and older people with osteoporosis: a systematic review and meta-analysis |
| title_full | Effect of exercise intervention on health-related quality of life in middle-aged and older people with osteoporosis: a systematic review and meta-analysis |
| title_fullStr | Effect of exercise intervention on health-related quality of life in middle-aged and older people with osteoporosis: a systematic review and meta-analysis |
| title_full_unstemmed | Effect of exercise intervention on health-related quality of life in middle-aged and older people with osteoporosis: a systematic review and meta-analysis |
| title_short | Effect of exercise intervention on health-related quality of life in middle-aged and older people with osteoporosis: a systematic review and meta-analysis |
| title_sort | effect of exercise intervention on health related quality of life in middle aged and older people with osteoporosis a systematic review and meta analysis |
| topic | Physical exercise Health-related quality of life Osteoporosis Middle-aged people Older people |
| url | https://peerj.com/articles/18889.pdf |
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