The Novelty of Human Cancer/Testis Antigen Encoding Genes in Evolution
In order to be inherited in progeny generations, novel genes should originate in germ cells. Here, we suggest that the testes may play a special “catalyst” role in the birth and evolution of new genes. Cancer/testis antigen encoding genes (CT genes) are predominantly expressed both in testes and in...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Genomics |
| Online Access: | http://dx.doi.org/10.1155/2013/105108 |
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| _version_ | 1832554738496831488 |
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| author | Pavel Dobrynin Ekaterina Matyunina S. V. Malov A. P. Kozlov |
| author_facet | Pavel Dobrynin Ekaterina Matyunina S. V. Malov A. P. Kozlov |
| author_sort | Pavel Dobrynin |
| collection | DOAJ |
| description | In order to be inherited in progeny generations, novel genes should originate in germ cells. Here, we suggest that the testes may play a special “catalyst” role in the birth and evolution of new genes. Cancer/testis antigen encoding genes (CT genes) are predominantly expressed both in testes and in a variety of tumors. By the criteria of evolutionary novelty, the CT genes are, indeed, novel genes. We performed homology searches for sequences similar to human CT in various animals and established that most of the CT genes are either found in humans only or are relatively recent in their origin. A majority of all human CT genes originated during or after the origin of Eutheria. These results suggest relatively recent origin of human CT genes and align with the hypothesis of the special role of the testes in the evolution of the gene families. |
| format | Article |
| id | doaj-art-dee308681c98466f8b942141762d9cdb |
| institution | Kabale University |
| issn | 2314-436X 2314-4378 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Genomics |
| spelling | doaj-art-dee308681c98466f8b942141762d9cdb2025-02-03T05:50:47ZengWileyInternational Journal of Genomics2314-436X2314-43782013-01-01201310.1155/2013/105108105108The Novelty of Human Cancer/Testis Antigen Encoding Genes in EvolutionPavel Dobrynin0Ekaterina Matyunina1S. V. Malov2A. P. Kozlov3The Biomedical Center, Saint Petersburg 194044, RussiaThe Biomedical Center, Saint Petersburg 194044, RussiaDobzhansky Center for Genome Bioinformatics, Saint Petersburg State University, Saint Petersburg 190004, RussiaThe Biomedical Center, Saint Petersburg 194044, RussiaIn order to be inherited in progeny generations, novel genes should originate in germ cells. Here, we suggest that the testes may play a special “catalyst” role in the birth and evolution of new genes. Cancer/testis antigen encoding genes (CT genes) are predominantly expressed both in testes and in a variety of tumors. By the criteria of evolutionary novelty, the CT genes are, indeed, novel genes. We performed homology searches for sequences similar to human CT in various animals and established that most of the CT genes are either found in humans only or are relatively recent in their origin. A majority of all human CT genes originated during or after the origin of Eutheria. These results suggest relatively recent origin of human CT genes and align with the hypothesis of the special role of the testes in the evolution of the gene families.http://dx.doi.org/10.1155/2013/105108 |
| spellingShingle | Pavel Dobrynin Ekaterina Matyunina S. V. Malov A. P. Kozlov The Novelty of Human Cancer/Testis Antigen Encoding Genes in Evolution International Journal of Genomics |
| title | The Novelty of Human Cancer/Testis Antigen Encoding Genes in Evolution |
| title_full | The Novelty of Human Cancer/Testis Antigen Encoding Genes in Evolution |
| title_fullStr | The Novelty of Human Cancer/Testis Antigen Encoding Genes in Evolution |
| title_full_unstemmed | The Novelty of Human Cancer/Testis Antigen Encoding Genes in Evolution |
| title_short | The Novelty of Human Cancer/Testis Antigen Encoding Genes in Evolution |
| title_sort | novelty of human cancer testis antigen encoding genes in evolution |
| url | http://dx.doi.org/10.1155/2013/105108 |
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