Histocompatibility and Hematopoietic Transplantation in the Zebrafish
The zebrafish has proven to be an excellent model for human disease, particularly hematopoietic diseases, since these fish make similar types of blood cells as humans and other mammals. The genetic program that regulates the development and differentiation of hematopoietic cells is highly conserved...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2012/282318 |
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| author | Jill L. O. de Jong Leonard I. Zon |
| author_facet | Jill L. O. de Jong Leonard I. Zon |
| author_sort | Jill L. O. de Jong |
| collection | DOAJ |
| description | The zebrafish has proven to be an excellent model for human disease, particularly hematopoietic diseases, since these fish make similar types of blood cells as humans and other mammals. The genetic program that regulates the development and differentiation of hematopoietic cells is highly conserved. Hematopoietic stem cells (HSCs) are the source of all the blood cells needed by an organism during its lifetime. Identifying an HSC requires a functional assay, namely, a transplantation assay consisting of multilineage engraftment of a recipient and subsequent serial transplant recipients. In the past decade, several types of hematopoietic transplant assays have been developed in the zebrafish. An understanding of the major histocompatibility complex (MHC) genes in the zebrafish has lagged behind transplantation experiments, limiting the ability to perform unbiased competitive transplantation assays. This paper summarizes the different hematopoietic transplantation experiments performed in the zebrafish, both with and without immunologic matching, and discusses future directions for this powerful experimental model of human blood diseases. |
| format | Article |
| id | doaj-art-dedc69d701ce408d811c48f8cc59d29d |
| institution | Kabale University |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-dedc69d701ce408d811c48f8cc59d29d2025-02-03T06:06:52ZengWileyAdvances in Hematology1687-91041687-91122012-01-01201210.1155/2012/282318282318Histocompatibility and Hematopoietic Transplantation in the ZebrafishJill L. O. de Jong0Leonard I. Zon1Section of Hematology-Oncology and Stem Cell Transplant, Department of Pediatrics, The University of Chicago, KCBD 5120, Chicago, IL 60637, USAStem Cell Program and Division of Hematology/Oncology, Children’s Hospital Boston-Dana, Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, and Harvard Medical School, Boston, MA 02115, USAThe zebrafish has proven to be an excellent model for human disease, particularly hematopoietic diseases, since these fish make similar types of blood cells as humans and other mammals. The genetic program that regulates the development and differentiation of hematopoietic cells is highly conserved. Hematopoietic stem cells (HSCs) are the source of all the blood cells needed by an organism during its lifetime. Identifying an HSC requires a functional assay, namely, a transplantation assay consisting of multilineage engraftment of a recipient and subsequent serial transplant recipients. In the past decade, several types of hematopoietic transplant assays have been developed in the zebrafish. An understanding of the major histocompatibility complex (MHC) genes in the zebrafish has lagged behind transplantation experiments, limiting the ability to perform unbiased competitive transplantation assays. This paper summarizes the different hematopoietic transplantation experiments performed in the zebrafish, both with and without immunologic matching, and discusses future directions for this powerful experimental model of human blood diseases.http://dx.doi.org/10.1155/2012/282318 |
| spellingShingle | Jill L. O. de Jong Leonard I. Zon Histocompatibility and Hematopoietic Transplantation in the Zebrafish Advances in Hematology |
| title | Histocompatibility and Hematopoietic Transplantation in the Zebrafish |
| title_full | Histocompatibility and Hematopoietic Transplantation in the Zebrafish |
| title_fullStr | Histocompatibility and Hematopoietic Transplantation in the Zebrafish |
| title_full_unstemmed | Histocompatibility and Hematopoietic Transplantation in the Zebrafish |
| title_short | Histocompatibility and Hematopoietic Transplantation in the Zebrafish |
| title_sort | histocompatibility and hematopoietic transplantation in the zebrafish |
| url | http://dx.doi.org/10.1155/2012/282318 |
| work_keys_str_mv | AT jilllodejong histocompatibilityandhematopoietictransplantationinthezebrafish AT leonardizon histocompatibilityandhematopoietictransplantationinthezebrafish |