Dystrophic Cutaneous Calcification and Metaplastic Bone Formation due to Long Term Bisphosphonate Use in Breast Cancer
Bisphosphonates are widely used in the treatment of breast cancer with bone metastases. We report a case of a female with breast cancer presented with a rash around a previous mastectomy site and a discharge lesion on her right chest wall in August 2010. Biopsy of the lesion showed dystrophic calcif...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2013/871917 |
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| author | Ali Murat Tatlı Seyda Gunduz Sema Sezgin Göksu Deniz Arslan Mukremin Uysal Cumhur İbrahim Başsorgun Hasan Şenol Coşkun |
| author_facet | Ali Murat Tatlı Seyda Gunduz Sema Sezgin Göksu Deniz Arslan Mukremin Uysal Cumhur İbrahim Başsorgun Hasan Şenol Coşkun |
| author_sort | Ali Murat Tatlı |
| collection | DOAJ |
| description | Bisphosphonates are widely used in the treatment of breast cancer with bone metastases. We report a case of a female with breast cancer presented with a rash around a previous mastectomy site and a discharge lesion on her right chest wall in August 2010. Biopsy of the lesion showed dystrophic calcification and metaplastic bone formation. The patient’s history revealed a long term use of zoledronic acid for the treatment of breast cancer with bone metastasis. We stopped the treatment since we believed that the cutaneous dystrophic calcification could be associated with her long term bisphosphonate therapy. Adverse cutaneous events with bisphosphonates are very rare, and dystrophic calcification has not been reported previously. The dystrophic calcification and metaplastic bone formation in this patient are thought to be due to long term bisphosphonate usage. |
| format | Article |
| id | doaj-art-deca4be351db4139a503ac3542f3b3c6 |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-deca4be351db4139a503ac3542f3b3c62025-02-03T05:46:17ZengWileyCase Reports in Oncological Medicine2090-67062090-67142013-01-01201310.1155/2013/871917871917Dystrophic Cutaneous Calcification and Metaplastic Bone Formation due to Long Term Bisphosphonate Use in Breast CancerAli Murat Tatlı0Seyda Gunduz1Sema Sezgin Göksu2Deniz Arslan3Mukremin Uysal4Cumhur İbrahim Başsorgun5Hasan Şenol Coşkun6Department of Medical Oncology, Faculty of Medicine, Akdeniz University, 07070 Antalya, TurkeyDepartment of Medical Oncology, Faculty of Medicine, Akdeniz University, 07070 Antalya, TurkeyDepartment of Medical Oncology, Faculty of Medicine, Akdeniz University, 07070 Antalya, TurkeyDepartment of Medical Oncology, Faculty of Medicine, Akdeniz University, 07070 Antalya, TurkeyDepartment of Medical Oncology, Faculty of Medicine, Afyon Kocatepe University, 03200 Afyonkarahisar, TurkeyDepartment of Pathology, Faculty of Medicine, Akdeniz University, 07070 Antalya, TurkeyDepartment of Medical Oncology, Faculty of Medicine, Akdeniz University, 07070 Antalya, TurkeyBisphosphonates are widely used in the treatment of breast cancer with bone metastases. We report a case of a female with breast cancer presented with a rash around a previous mastectomy site and a discharge lesion on her right chest wall in August 2010. Biopsy of the lesion showed dystrophic calcification and metaplastic bone formation. The patient’s history revealed a long term use of zoledronic acid for the treatment of breast cancer with bone metastasis. We stopped the treatment since we believed that the cutaneous dystrophic calcification could be associated with her long term bisphosphonate therapy. Adverse cutaneous events with bisphosphonates are very rare, and dystrophic calcification has not been reported previously. The dystrophic calcification and metaplastic bone formation in this patient are thought to be due to long term bisphosphonate usage.http://dx.doi.org/10.1155/2013/871917 |
| spellingShingle | Ali Murat Tatlı Seyda Gunduz Sema Sezgin Göksu Deniz Arslan Mukremin Uysal Cumhur İbrahim Başsorgun Hasan Şenol Coşkun Dystrophic Cutaneous Calcification and Metaplastic Bone Formation due to Long Term Bisphosphonate Use in Breast Cancer Case Reports in Oncological Medicine |
| title | Dystrophic Cutaneous Calcification and Metaplastic Bone Formation due to Long Term Bisphosphonate Use in Breast Cancer |
| title_full | Dystrophic Cutaneous Calcification and Metaplastic Bone Formation due to Long Term Bisphosphonate Use in Breast Cancer |
| title_fullStr | Dystrophic Cutaneous Calcification and Metaplastic Bone Formation due to Long Term Bisphosphonate Use in Breast Cancer |
| title_full_unstemmed | Dystrophic Cutaneous Calcification and Metaplastic Bone Formation due to Long Term Bisphosphonate Use in Breast Cancer |
| title_short | Dystrophic Cutaneous Calcification and Metaplastic Bone Formation due to Long Term Bisphosphonate Use in Breast Cancer |
| title_sort | dystrophic cutaneous calcification and metaplastic bone formation due to long term bisphosphonate use in breast cancer |
| url | http://dx.doi.org/10.1155/2013/871917 |
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