Deoxynivalenol mycotoxin dietary exposure on broiler performance and small intestine health: A comprehensive meta-analysis
The effect of DON mycotoxins on broiler production performance and the small intestine is a critical factor in the health and well-being of broilers. Several studies have been conducted on this topic and have reported varying results and conclusions. Therefore, it is necessary to conduct systematic...
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Elsevier
2024-12-01
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| Series: | Poultry Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0032579124009908 |
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| author | Chala Adugna Kai Wang Jian Du Chunmei Li |
| author_facet | Chala Adugna Kai Wang Jian Du Chunmei Li |
| author_sort | Chala Adugna |
| collection | DOAJ |
| description | The effect of DON mycotoxins on broiler production performance and the small intestine is a critical factor in the health and well-being of broilers. Several studies have been conducted on this topic and have reported varying results and conclusions. Therefore, it is necessary to conduct systematic reviews and meta-analyses to thoroughly examine and draw unique conclusions. In this meta-analysis, we conducted a systematic review of multiple studies on the effects of DON mycotoxins in broilers. The analysis comprised 26 articles from reputable journals, and 14 parameters were identified based on the predetermined criteria. The forest plot results showed that DON treatment significantly reduced the ADFI and ADWG (SMD-1.50, 95 %CI [-1.68, -1.18]; I2= 51 %; p < 0.00001) and affected FCR (SMD 0.95, 95 %CI [ 0.62, 1.28]; I2= 77; p < 0.00001). In addition, it affects the small intestine structure duodenum (SMD -3.46, 95 %CI [-3.88, -3.05]; I2= 48 %; p < 0.00001), Jejunum (SMD -5.35, 95 %CI [-5.86, -4.83]; I2= 62 %; p < 0.00001), Ileum (SMD -2.6, 95 % CI [-3.12, -2.08]; I2= 82 %; p < 0.00001). Furthermore, DON exposure affects immunoglobulin (SMD -1.92, 95 % CI [ -2.39, -1.46]; I2 = 54 %; p < 0.00001) and antioxidant activities (SMD -2.1, 95 % CI [ -2.45, -1.75]; I2= 47 %; p < 0.00001). The overall effect of DON treatment was statistically significant compared with that of the control group. Furthermore, funnel plot analysis for publication bias did not reveal any significant asymmetry in most included studies. The results of this meta-analysis indicate that DON mycotoxins have a significant impact on both production performance and small intestine health and require strategic intervention. |
| format | Article |
| id | doaj-art-debdadf296104cf7bdca97fc40586c8d |
| institution | DOAJ |
| issn | 0032-5791 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Poultry Science |
| spelling | doaj-art-debdadf296104cf7bdca97fc40586c8d2025-08-20T02:39:15ZengElsevierPoultry Science0032-57912024-12-011031210441210.1016/j.psj.2024.104412Deoxynivalenol mycotoxin dietary exposure on broiler performance and small intestine health: A comprehensive meta-analysisChala Adugna0Kai Wang1Jian Du2Chunmei Li3Research Centre for Livestock Environmental Control and Smart Production, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China; Ambo University College of Agriculture and Veterinary Science, EthiopiaResearch Centre for Livestock Environmental Control and Smart Production, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, ChinaResearch Centre for Livestock Environmental Control and Smart Production, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, ChinaResearch Centre for Livestock Environmental Control and Smart Production, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China; Corresponding author.The effect of DON mycotoxins on broiler production performance and the small intestine is a critical factor in the health and well-being of broilers. Several studies have been conducted on this topic and have reported varying results and conclusions. Therefore, it is necessary to conduct systematic reviews and meta-analyses to thoroughly examine and draw unique conclusions. In this meta-analysis, we conducted a systematic review of multiple studies on the effects of DON mycotoxins in broilers. The analysis comprised 26 articles from reputable journals, and 14 parameters were identified based on the predetermined criteria. The forest plot results showed that DON treatment significantly reduced the ADFI and ADWG (SMD-1.50, 95 %CI [-1.68, -1.18]; I2= 51 %; p < 0.00001) and affected FCR (SMD 0.95, 95 %CI [ 0.62, 1.28]; I2= 77; p < 0.00001). In addition, it affects the small intestine structure duodenum (SMD -3.46, 95 %CI [-3.88, -3.05]; I2= 48 %; p < 0.00001), Jejunum (SMD -5.35, 95 %CI [-5.86, -4.83]; I2= 62 %; p < 0.00001), Ileum (SMD -2.6, 95 % CI [-3.12, -2.08]; I2= 82 %; p < 0.00001). Furthermore, DON exposure affects immunoglobulin (SMD -1.92, 95 % CI [ -2.39, -1.46]; I2 = 54 %; p < 0.00001) and antioxidant activities (SMD -2.1, 95 % CI [ -2.45, -1.75]; I2= 47 %; p < 0.00001). The overall effect of DON treatment was statistically significant compared with that of the control group. Furthermore, funnel plot analysis for publication bias did not reveal any significant asymmetry in most included studies. The results of this meta-analysis indicate that DON mycotoxins have a significant impact on both production performance and small intestine health and require strategic intervention.http://www.sciencedirect.com/science/article/pii/S0032579124009908BroilerDON mycotoxinFeed intakeWeight gainSmall intestine |
| spellingShingle | Chala Adugna Kai Wang Jian Du Chunmei Li Deoxynivalenol mycotoxin dietary exposure on broiler performance and small intestine health: A comprehensive meta-analysis Poultry Science Broiler DON mycotoxin Feed intake Weight gain Small intestine |
| title | Deoxynivalenol mycotoxin dietary exposure on broiler performance and small intestine health: A comprehensive meta-analysis |
| title_full | Deoxynivalenol mycotoxin dietary exposure on broiler performance and small intestine health: A comprehensive meta-analysis |
| title_fullStr | Deoxynivalenol mycotoxin dietary exposure on broiler performance and small intestine health: A comprehensive meta-analysis |
| title_full_unstemmed | Deoxynivalenol mycotoxin dietary exposure on broiler performance and small intestine health: A comprehensive meta-analysis |
| title_short | Deoxynivalenol mycotoxin dietary exposure on broiler performance and small intestine health: A comprehensive meta-analysis |
| title_sort | deoxynivalenol mycotoxin dietary exposure on broiler performance and small intestine health a comprehensive meta analysis |
| topic | Broiler DON mycotoxin Feed intake Weight gain Small intestine |
| url | http://www.sciencedirect.com/science/article/pii/S0032579124009908 |
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