Nasopharyngeal Carcinoma Signaling Pathway: An Update on Molecular Biomarkers
Nasopharyngeal carcinoma (NPC) is an uncommon cancer, which has a distinctive ethnic and geographic distribution. Etiology of NPC is considered to be related with a complex interaction of environmental and genetic factors as well as Epstein-Barr virus infection. Since NPC is located in the silent pa...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2012/594681 |
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| _version_ | 1832548709083119616 |
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| author | Warut Tulalamba Tavan Janvilisri |
| author_facet | Warut Tulalamba Tavan Janvilisri |
| author_sort | Warut Tulalamba |
| collection | DOAJ |
| description | Nasopharyngeal carcinoma (NPC) is an uncommon cancer, which has a distinctive ethnic and geographic distribution. Etiology of NPC is considered to be related with a complex interaction of environmental and genetic factors as well as Epstein-Barr virus infection. Since NPC is located in the silent painless area, the disease is usually therefore diagnosed at the advanced stages; hence early detection of NPC is difficult. Furthermore, understanding in molecular pathogenesis is still lacking, pondering the identification of effective prognostic and diagnostic biomarkers. Dysregulation of signaling molecules in intracellular signal transduction, which regulate cell proliferation, apoptosis, and adhesion, underlines the basis of NPC pathogenesis. In this paper, the molecular signaling pathways in the NPC are discussed for the holistic view of NPC development and progression. The important insights toward NPC pathogenesis may offer strategies for identification of novel biomarkers for diagnosis and prognosis. |
| format | Article |
| id | doaj-art-deb1617c1b9f40e9aff62119347cd4a8 |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-deb1617c1b9f40e9aff62119347cd4a82025-02-03T06:13:21ZengWileyInternational Journal of Cell Biology1687-88761687-88842012-01-01201210.1155/2012/594681594681Nasopharyngeal Carcinoma Signaling Pathway: An Update on Molecular BiomarkersWarut Tulalamba0Tavan Janvilisri1Graduate Program in Molecular Medicine, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, ThailandDepartment of Biology, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, ThailandNasopharyngeal carcinoma (NPC) is an uncommon cancer, which has a distinctive ethnic and geographic distribution. Etiology of NPC is considered to be related with a complex interaction of environmental and genetic factors as well as Epstein-Barr virus infection. Since NPC is located in the silent painless area, the disease is usually therefore diagnosed at the advanced stages; hence early detection of NPC is difficult. Furthermore, understanding in molecular pathogenesis is still lacking, pondering the identification of effective prognostic and diagnostic biomarkers. Dysregulation of signaling molecules in intracellular signal transduction, which regulate cell proliferation, apoptosis, and adhesion, underlines the basis of NPC pathogenesis. In this paper, the molecular signaling pathways in the NPC are discussed for the holistic view of NPC development and progression. The important insights toward NPC pathogenesis may offer strategies for identification of novel biomarkers for diagnosis and prognosis.http://dx.doi.org/10.1155/2012/594681 |
| spellingShingle | Warut Tulalamba Tavan Janvilisri Nasopharyngeal Carcinoma Signaling Pathway: An Update on Molecular Biomarkers International Journal of Cell Biology |
| title | Nasopharyngeal Carcinoma Signaling Pathway: An Update on Molecular Biomarkers |
| title_full | Nasopharyngeal Carcinoma Signaling Pathway: An Update on Molecular Biomarkers |
| title_fullStr | Nasopharyngeal Carcinoma Signaling Pathway: An Update on Molecular Biomarkers |
| title_full_unstemmed | Nasopharyngeal Carcinoma Signaling Pathway: An Update on Molecular Biomarkers |
| title_short | Nasopharyngeal Carcinoma Signaling Pathway: An Update on Molecular Biomarkers |
| title_sort | nasopharyngeal carcinoma signaling pathway an update on molecular biomarkers |
| url | http://dx.doi.org/10.1155/2012/594681 |
| work_keys_str_mv | AT waruttulalamba nasopharyngealcarcinomasignalingpathwayanupdateonmolecularbiomarkers AT tavanjanvilisri nasopharyngealcarcinomasignalingpathwayanupdateonmolecularbiomarkers |