Inhaled Nitric Oxide Counterbalances ET-1 Dependent Pulmonary Hypertension and Bronchoconstriction in the Pig
In anaesthetized, paralysed, ventilated pigs the ability of inhaled nitric oxide (80 ppm in 02) to reduce the haemodynamic and respiratory effects of endothelin-1 administration (200 pmol/kg, i.v.) was evaluated. The mechanical properties of the respiratory system were evaluated by the rapid airway...
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| Format: | Article |
| Language: | English |
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Wiley
1994-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935194000165 |
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| author | M. G. Clement M. Dimori |
| author_facet | M. G. Clement M. Dimori |
| author_sort | M. G. Clement |
| collection | DOAJ |
| description | In anaesthetized, paralysed, ventilated pigs the ability of
inhaled nitric oxide (80 ppm in 02) to reduce the
haemodynamic and respiratory effects of endothelin-1
administration (200 pmol/kg, i.v.) was evaluated. The
mechanical properties of the respiratory system were
evaluated by the rapid airway occlusion technique. The
overall respiratory resistance, the interrupter resistance
and the additional resistance that reflects the viscoelastic
properties of tissues and the inequality of the time constant
within the system were also evaluated. The results
show that inhaled nitric oxide can act as a selective
pulmonary vasodilator and as a bronchodilator to counteract
the vasoconstrictor and bronchoconstrictor activity
of endothelin-1. In the pig, nitric oxide inhaled at 80
ppm for 6 mitt reduced the changes in respiratory-, interrupter-
and additional resistance due to endothelin-1 administration
without significantly changing the static and
dynamic elastance of the respiratory system. |
| format | Article |
| id | doaj-art-dea80754c9d0498793eccff2f1f3d816 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1994-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-dea80754c9d0498793eccff2f1f3d8162025-02-03T05:51:05ZengWileyMediators of Inflammation0962-93511466-18611994-01-013213113510.1155/S0962935194000165Inhaled Nitric Oxide Counterbalances ET-1 Dependent Pulmonary Hypertension and Bronchoconstriction in the PigM. G. Clement0M. Dimori1Institute of Veterinary Physiology and Biochemistry, University of Milan, Via Celoria 10, Milan 20133, ItalyInstitute of Veterinary Physiology and Biochemistry, University of Milan, Via Celoria 10, Milan 20133, ItalyIn anaesthetized, paralysed, ventilated pigs the ability of inhaled nitric oxide (80 ppm in 02) to reduce the haemodynamic and respiratory effects of endothelin-1 administration (200 pmol/kg, i.v.) was evaluated. The mechanical properties of the respiratory system were evaluated by the rapid airway occlusion technique. The overall respiratory resistance, the interrupter resistance and the additional resistance that reflects the viscoelastic properties of tissues and the inequality of the time constant within the system were also evaluated. The results show that inhaled nitric oxide can act as a selective pulmonary vasodilator and as a bronchodilator to counteract the vasoconstrictor and bronchoconstrictor activity of endothelin-1. In the pig, nitric oxide inhaled at 80 ppm for 6 mitt reduced the changes in respiratory-, interrupter- and additional resistance due to endothelin-1 administration without significantly changing the static and dynamic elastance of the respiratory system.http://dx.doi.org/10.1155/S0962935194000165 |
| spellingShingle | M. G. Clement M. Dimori Inhaled Nitric Oxide Counterbalances ET-1 Dependent Pulmonary Hypertension and Bronchoconstriction in the Pig Mediators of Inflammation |
| title | Inhaled Nitric Oxide Counterbalances ET-1 Dependent Pulmonary Hypertension and Bronchoconstriction in the Pig |
| title_full | Inhaled Nitric Oxide Counterbalances ET-1 Dependent Pulmonary Hypertension and Bronchoconstriction in the Pig |
| title_fullStr | Inhaled Nitric Oxide Counterbalances ET-1 Dependent Pulmonary Hypertension and Bronchoconstriction in the Pig |
| title_full_unstemmed | Inhaled Nitric Oxide Counterbalances ET-1 Dependent Pulmonary Hypertension and Bronchoconstriction in the Pig |
| title_short | Inhaled Nitric Oxide Counterbalances ET-1 Dependent Pulmonary Hypertension and Bronchoconstriction in the Pig |
| title_sort | inhaled nitric oxide counterbalances et 1 dependent pulmonary hypertension and bronchoconstriction in the pig |
| url | http://dx.doi.org/10.1155/S0962935194000165 |
| work_keys_str_mv | AT mgclement inhalednitricoxidecounterbalanceset1dependentpulmonaryhypertensionandbronchoconstrictioninthepig AT mdimori inhalednitricoxidecounterbalanceset1dependentpulmonaryhypertensionandbronchoconstrictioninthepig |