Investigating orbital foreign device-associated malignancies: a scoping review
Abstract Background While prosthesis-associated malignancies have been acknowledged, awareness among surgeons and patients in the ophthalmologic field remains limited, despite the frequent occurrence of prosthesis-related surgeries. We aim to address this gap through a scoping review of malignancies...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-024-13422-z |
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| author | Jeong Hyun Ha Jagmeet S. Arora Jamasb J. Sayadi Nada R. Khattab Shannon D. Francis Thomas M. Johnstone Yeonji Jang Gordon K. Lee |
| author_facet | Jeong Hyun Ha Jagmeet S. Arora Jamasb J. Sayadi Nada R. Khattab Shannon D. Francis Thomas M. Johnstone Yeonji Jang Gordon K. Lee |
| author_sort | Jeong Hyun Ha |
| collection | DOAJ |
| description | Abstract Background While prosthesis-associated malignancies have been acknowledged, awareness among surgeons and patients in the ophthalmologic field remains limited, despite the frequent occurrence of prosthesis-related surgeries. We aim to address this gap through a scoping review of malignancies following ophthalmologic surgeries involving various foreign device/prosthesis/implants. Methods Following PRISMA guidelines, we conducted a review using PubMed and Embase for studies on cancer and ophthalmic prostheses/implants. The final selection of articles for the ophthalmology aspect underwent rigorous investigation. Results We analyzed 30 studies, identifying 41 cases of malignancies following interventions involving orbital foreign devices. Foreign devices linked to malignancies included scleral shells, orbital implants, scleral buckles, encircling bands, and gold plates. Ocular surface squamous neoplasm was most common, with 29 cases. Other malignancies observed were pleomorphic sarcoma, synovial sarcoma, marginal zone B-cell lymphoma, sebaceous carcinoma, malignant melanoma, adenocarcinoma, and metastatic lung adenocarcinoma. These malignancies varied in characteristics and demographics, with some showing metastasis or local invasion. The median time to tumor development was 40 years. Conclusions This study highlights a spectrum of malignancies following orbital foreign device procedures and suggests a potential association between different types of orbital foreign devices and malignancies. Future studies, including well-designed epidemiologic studies and scientific experiments, are warranted to elucidate the causal relationship. |
| format | Article |
| id | doaj-art-dea127b7305d4301a00dcf0287e5057a |
| institution | Kabale University |
| issn | 1471-2407 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj-art-dea127b7305d4301a00dcf0287e5057a2025-02-02T12:28:55ZengBMCBMC Cancer1471-24072025-01-0125111310.1186/s12885-024-13422-zInvestigating orbital foreign device-associated malignancies: a scoping reviewJeong Hyun Ha0Jagmeet S. Arora1Jamasb J. Sayadi2Nada R. Khattab3Shannon D. Francis4Thomas M. Johnstone5Yeonji Jang6Gordon K. Lee7Interdisciplinary Program of Medical Informatics, Seoul National University College of MedicineSchool of Medicine, University of CaliforniaDepartment of Neurosurgery, Stanford UniversityDepartment of Plastic Surgery, The Ohio State UniversityStanford University School of MedicineStanford University School of MedicineDepartment of Ophthalmology, Uijeongbu Eulji Medical Center and Eulji UniversityDepartment of Plastic Surgery, University of CaliforniaAbstract Background While prosthesis-associated malignancies have been acknowledged, awareness among surgeons and patients in the ophthalmologic field remains limited, despite the frequent occurrence of prosthesis-related surgeries. We aim to address this gap through a scoping review of malignancies following ophthalmologic surgeries involving various foreign device/prosthesis/implants. Methods Following PRISMA guidelines, we conducted a review using PubMed and Embase for studies on cancer and ophthalmic prostheses/implants. The final selection of articles for the ophthalmology aspect underwent rigorous investigation. Results We analyzed 30 studies, identifying 41 cases of malignancies following interventions involving orbital foreign devices. Foreign devices linked to malignancies included scleral shells, orbital implants, scleral buckles, encircling bands, and gold plates. Ocular surface squamous neoplasm was most common, with 29 cases. Other malignancies observed were pleomorphic sarcoma, synovial sarcoma, marginal zone B-cell lymphoma, sebaceous carcinoma, malignant melanoma, adenocarcinoma, and metastatic lung adenocarcinoma. These malignancies varied in characteristics and demographics, with some showing metastasis or local invasion. The median time to tumor development was 40 years. Conclusions This study highlights a spectrum of malignancies following orbital foreign device procedures and suggests a potential association between different types of orbital foreign devices and malignancies. Future studies, including well-designed epidemiologic studies and scientific experiments, are warranted to elucidate the causal relationship.https://doi.org/10.1186/s12885-024-13422-zOrbital prosthetic deviceOrbital foreign deviceConjunctival carcinomaSarcomaOcular malignancy |
| spellingShingle | Jeong Hyun Ha Jagmeet S. Arora Jamasb J. Sayadi Nada R. Khattab Shannon D. Francis Thomas M. Johnstone Yeonji Jang Gordon K. Lee Investigating orbital foreign device-associated malignancies: a scoping review BMC Cancer Orbital prosthetic device Orbital foreign device Conjunctival carcinoma Sarcoma Ocular malignancy |
| title | Investigating orbital foreign device-associated malignancies: a scoping review |
| title_full | Investigating orbital foreign device-associated malignancies: a scoping review |
| title_fullStr | Investigating orbital foreign device-associated malignancies: a scoping review |
| title_full_unstemmed | Investigating orbital foreign device-associated malignancies: a scoping review |
| title_short | Investigating orbital foreign device-associated malignancies: a scoping review |
| title_sort | investigating orbital foreign device associated malignancies a scoping review |
| topic | Orbital prosthetic device Orbital foreign device Conjunctival carcinoma Sarcoma Ocular malignancy |
| url | https://doi.org/10.1186/s12885-024-13422-z |
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