Gut microbiota mediates SREBP-1c-driven hepatic lipogenesis and steatosis in response to zero-fat high-sucrose diet

Gut microbiota mediates SREBP-1c-driven hepatic lipogenesis and steatosis in response to zero-fat high-sucrose diet

Objectives: Sucrose-rich diets promote hepatic de novo lipogenesis (DNL) and steatosis through interactions with the gut microbiota. However, the role of sugar-microbiota dynamics in the absence of dietary fat remains unclear. This study aimed to investigate the effects of a high-sucrose, zero-fat d...

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Main Authors: Mattias Bergentall, Valentina Tremaroli, Chuqing Sun, Marcus Henricsson, Muhammad Tanweer Khan, Louise Mannerås Holm, Lisa Olsson, Per-Olof Bergh, Antonio Molinaro, Adil Mardinoglu, Robert Caesar, Max Nieuwdorp, Fredrik Bäckhed
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Molecular Metabolism
Subjects:
de novo lipogenesis
Gut microbiota
Hepatic steatosis
High-sucrose diet
Metabolomics
SREBP-1c
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877825000699
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