Advances and Challenges in Antiviral Development for Respiratory Viruses
The development of antivirals for respiratory viruses has advanced markedly in response to the growing threat of pathogens such as Influenzavirus (IAV), respiratory syncytial virus (RSV), and SARS-CoV-2. This article reviews the advances and challenges in this field, highlighting therapeutic strateg...
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| Language: | English |
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MDPI AG
2024-12-01
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| Online Access: | https://www.mdpi.com/2076-0817/14/1/20 |
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| author | Luis Adrián De Jesús-González Moisés León-Juárez Flor Itzel Lira-Hernández Bruno Rivas-Santiago Manuel Adrián Velázquez-Cervantes Iridiana Monserrat Méndez-Delgado Daniela Itzel Macías-Guerrero Jonathan Hernández-Castillo Ximena Hernández-Rodríguez Daniela Nahomi Calderón-Sandate Willy Salvador Mata-Martínez José Manuel Reyes-Ruíz Juan Fidel Osuna-Ramos Ana Cristina García-Herrera |
| author_facet | Luis Adrián De Jesús-González Moisés León-Juárez Flor Itzel Lira-Hernández Bruno Rivas-Santiago Manuel Adrián Velázquez-Cervantes Iridiana Monserrat Méndez-Delgado Daniela Itzel Macías-Guerrero Jonathan Hernández-Castillo Ximena Hernández-Rodríguez Daniela Nahomi Calderón-Sandate Willy Salvador Mata-Martínez José Manuel Reyes-Ruíz Juan Fidel Osuna-Ramos Ana Cristina García-Herrera |
| author_sort | Luis Adrián De Jesús-González |
| collection | DOAJ |
| description | The development of antivirals for respiratory viruses has advanced markedly in response to the growing threat of pathogens such as Influenzavirus (IAV), respiratory syncytial virus (RSV), and SARS-CoV-2. This article reviews the advances and challenges in this field, highlighting therapeutic strategies that target critical stages of the viral replication cycle, including inhibitors of viral entry, replication, and assembly. In addition, innovative approaches such as inhibiting host cellular proteins to reduce viral resistance and repurposing existing drugs are explored, using advanced bioinformatics tools that optimize the identification of antiviral candidates. The analysis also covers emerging technologies such as nanomedicine and CRISPR gene editing, which promise to improve the stability and efficacy of treatments. While current antivirals offer valuable options, they face challenges such as viral evolution and the need for accessible treatments for vulnerable populations. This article underscores the importance of continued innovation in biotechnology to overcome these limitations and provide safe and effective treatments. Combining traditional and advanced approaches in developing antivirals is essential in order to address respiratory viral diseases that affect global health. |
| format | Article |
| id | doaj-art-de9cb59b3ddd41e1aa085b7fc0b08cd3 |
| institution | Kabale University |
| issn | 2076-0817 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj-art-de9cb59b3ddd41e1aa085b7fc0b08cd32025-01-24T13:44:37ZengMDPI AGPathogens2076-08172024-12-011412010.3390/pathogens14010020Advances and Challenges in Antiviral Development for Respiratory VirusesLuis Adrián De Jesús-González0Moisés León-Juárez1Flor Itzel Lira-Hernández2Bruno Rivas-Santiago3Manuel Adrián Velázquez-Cervantes4Iridiana Monserrat Méndez-Delgado5Daniela Itzel Macías-Guerrero6Jonathan Hernández-Castillo7Ximena Hernández-Rodríguez8Daniela Nahomi Calderón-Sandate9Willy Salvador Mata-Martínez10José Manuel Reyes-Ruíz11Juan Fidel Osuna-Ramos12Ana Cristina García-Herrera13Unidad de Investigación Biomédica de Zacatecas, Instituto Mexicano del Seguro Social, Zacatecas 98000, MexicoLaboratorio de Virología Perinatal y Diseño Molecular de Antígenos y Biomarcadores, Departamento de Inmunobioquímica, Instituto Nacional de Perinatología, Ciudad de México 11000, MexicoUnidad de Investigación Biomédica de Zacatecas, Instituto Mexicano del Seguro Social, Zacatecas 98000, MexicoUnidad de Investigación Biomédica de Zacatecas, Instituto Mexicano del Seguro Social, Zacatecas 98000, MexicoLaboratorio de Virología Perinatal y Diseño Molecular de Antígenos y Biomarcadores, Departamento de Inmunobioquímica, Instituto Nacional de Perinatología, Ciudad de México 11000, MexicoUnidad de Investigación Biomédica de Zacatecas, Instituto Mexicano del Seguro Social, Zacatecas 98000, MexicoUnidad de Investigación Biomédica de Zacatecas, Instituto Mexicano del Seguro Social, Zacatecas 98000, MexicoDepartment of Infectomics and Molecular Pathogenesis, Center for Research and Advanced Studies (CINVESTAV-IPN), Mexico City 07360, MexicoUnidad de Investigación Biomédica de Zacatecas, Instituto Mexicano del Seguro Social, Zacatecas 98000, MexicoUnidad de Investigación Biomédica de Zacatecas, Instituto Mexicano del Seguro Social, Zacatecas 98000, MexicoUnidad de Investigación Biomédica de Zacatecas, Instituto Mexicano del Seguro Social, Zacatecas 98000, MexicoDivisión de Investigación en Salud, Unidad Médica de Alta Especialidad, Hospital de Especialidades No. 14, Centro Médico Nacional “Adolfo Ruiz Cortines”, Instituto Mexicano del Seguro Social (IMSS), Veracruz 91897, MexicoFacultad de Medicina, Universidad Autónoma de Sinaloa, Culiacán 80019, MexicoUnidad de Investigación Biomédica de Zacatecas, Instituto Mexicano del Seguro Social, Zacatecas 98000, MexicoThe development of antivirals for respiratory viruses has advanced markedly in response to the growing threat of pathogens such as Influenzavirus (IAV), respiratory syncytial virus (RSV), and SARS-CoV-2. This article reviews the advances and challenges in this field, highlighting therapeutic strategies that target critical stages of the viral replication cycle, including inhibitors of viral entry, replication, and assembly. In addition, innovative approaches such as inhibiting host cellular proteins to reduce viral resistance and repurposing existing drugs are explored, using advanced bioinformatics tools that optimize the identification of antiviral candidates. The analysis also covers emerging technologies such as nanomedicine and CRISPR gene editing, which promise to improve the stability and efficacy of treatments. While current antivirals offer valuable options, they face challenges such as viral evolution and the need for accessible treatments for vulnerable populations. This article underscores the importance of continued innovation in biotechnology to overcome these limitations and provide safe and effective treatments. Combining traditional and advanced approaches in developing antivirals is essential in order to address respiratory viral diseases that affect global health.https://www.mdpi.com/2076-0817/14/1/20antiviralsrespiratory virusesviral replicationentry inhibitiondrug repurposing |
| spellingShingle | Luis Adrián De Jesús-González Moisés León-Juárez Flor Itzel Lira-Hernández Bruno Rivas-Santiago Manuel Adrián Velázquez-Cervantes Iridiana Monserrat Méndez-Delgado Daniela Itzel Macías-Guerrero Jonathan Hernández-Castillo Ximena Hernández-Rodríguez Daniela Nahomi Calderón-Sandate Willy Salvador Mata-Martínez José Manuel Reyes-Ruíz Juan Fidel Osuna-Ramos Ana Cristina García-Herrera Advances and Challenges in Antiviral Development for Respiratory Viruses Pathogens antivirals respiratory viruses viral replication entry inhibition drug repurposing |
| title | Advances and Challenges in Antiviral Development for Respiratory Viruses |
| title_full | Advances and Challenges in Antiviral Development for Respiratory Viruses |
| title_fullStr | Advances and Challenges in Antiviral Development for Respiratory Viruses |
| title_full_unstemmed | Advances and Challenges in Antiviral Development for Respiratory Viruses |
| title_short | Advances and Challenges in Antiviral Development for Respiratory Viruses |
| title_sort | advances and challenges in antiviral development for respiratory viruses |
| topic | antivirals respiratory viruses viral replication entry inhibition drug repurposing |
| url | https://www.mdpi.com/2076-0817/14/1/20 |
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