The clinical significance of T cell infiltration and immune checkpoint expression in central nervous system germ cell tumors

The clinical significance of T cell infiltration and immune checkpoint expression in central nervous system germ cell tumors

BackgroundPrimary central nervous system germ cell tumors (CNS GCTs) are rare intracranial malignancies, and their tumor microenvironment plays a crucial role in tumor initiation and progression. However, the specific characteristics of the immune microenvironment and their clinical significance rem...

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Bibliographic Details
Main Authors: Jiajun Zhou, Wenhao An, Lei Guan, Jinyu Shi, Qiaozhen Qin, Shuai Zhong, Zheng Huang, Rui Liu, Chenxing Wu, Zhong Ma, Xueling Qi, Xiaoxia Jiang, Yan Wang, Shouwei Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
germ cell tumor
tumor microenvironment
tumor-infiltrating lymphocyte (TILs)
immune checkpoint
Foxp3
CTLA-4
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1536722/full
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