Long-term consequences of adolescent exposure to the synthetic cannabinoid AB-FUBINACA in male and female mice
Summary: The consumption of synthetic cannabinoids during adolescence is reported to be a risk factor for the appearance of psychiatric disorders later in life. AB-FUBINACA is a member of the indazole carboxamide family of synthetic cannabinoids present in Spice/K2 preparations. The present study so...
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| Language: | English |
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Elsevier
2025-02-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004225001178 |
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| author | Cristina Izquierdo-Luengo María Ponce-Renilla Marc Ten-Blanco María Andrea Arnanz Rosa María Tolón Inmaculada Pereda-Pérez Fernando Berrendero |
| author_facet | Cristina Izquierdo-Luengo María Ponce-Renilla Marc Ten-Blanco María Andrea Arnanz Rosa María Tolón Inmaculada Pereda-Pérez Fernando Berrendero |
| author_sort | Cristina Izquierdo-Luengo |
| collection | DOAJ |
| description | Summary: The consumption of synthetic cannabinoids during adolescence is reported to be a risk factor for the appearance of psychiatric disorders later in life. AB-FUBINACA is a member of the indazole carboxamide family of synthetic cannabinoids present in Spice/K2 preparations. The present study sought to investigate the long-term effects of AB-FUBINACA consumption during adolescence in both male and female mice. AB-FUBINACA revealed several sex-dependent behavioral alterations. In this sense, the administration of this synthetic cannabinoid in female, but not male, mice induced psychotic-like symptoms which were associated with changes in dendritic arborization and density of mature dendritic spines in pyramidal neurons of the prefrontal cortex, as well as with an up-regulation of differentially expressed genes in this brain area. This study helps to clarify the potential late detrimental effects of this potent synthetic cannabinoid that may derive from its use during adolescence. |
| format | Article |
| id | doaj-art-de96fd7e890e4d298191bfb05d803d8a |
| institution | Kabale University |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-de96fd7e890e4d298191bfb05d803d8a2025-02-05T04:32:32ZengElsevieriScience2589-00422025-02-01282111857Long-term consequences of adolescent exposure to the synthetic cannabinoid AB-FUBINACA in male and female miceCristina Izquierdo-Luengo0María Ponce-Renilla1Marc Ten-Blanco2María Andrea Arnanz3Rosa María Tolón4Inmaculada Pereda-Pérez5Fernando Berrendero6Institute of Life Sciences, Faculty of Experimental Sciences, Universidad Francisco de Vitoria, 28223 Pozuelo de Alarcón, Madrid, SpainInstitute of Life Sciences, Faculty of Experimental Sciences, Universidad Francisco de Vitoria, 28223 Pozuelo de Alarcón, Madrid, SpainInstitute of Life Sciences, Faculty of Experimental Sciences, Universidad Francisco de Vitoria, 28223 Pozuelo de Alarcón, Madrid, SpainInstitute of Life Sciences, Faculty of Experimental Sciences, Universidad Francisco de Vitoria, 28223 Pozuelo de Alarcón, Madrid, SpainInstitute of Life Sciences, Faculty of Experimental Sciences, Universidad Francisco de Vitoria, 28223 Pozuelo de Alarcón, Madrid, SpainDepartment of Psychobiology, Faculty of Psychology, Universidad Complutense, 28224 Pozuelo de Alarcón, Madrid, Spain; Corresponding authorInstitute of Life Sciences, Faculty of Experimental Sciences, Universidad Francisco de Vitoria, 28223 Pozuelo de Alarcón, Madrid, Spain; Corresponding authorSummary: The consumption of synthetic cannabinoids during adolescence is reported to be a risk factor for the appearance of psychiatric disorders later in life. AB-FUBINACA is a member of the indazole carboxamide family of synthetic cannabinoids present in Spice/K2 preparations. The present study sought to investigate the long-term effects of AB-FUBINACA consumption during adolescence in both male and female mice. AB-FUBINACA revealed several sex-dependent behavioral alterations. In this sense, the administration of this synthetic cannabinoid in female, but not male, mice induced psychotic-like symptoms which were associated with changes in dendritic arborization and density of mature dendritic spines in pyramidal neurons of the prefrontal cortex, as well as with an up-regulation of differentially expressed genes in this brain area. This study helps to clarify the potential late detrimental effects of this potent synthetic cannabinoid that may derive from its use during adolescence.http://www.sciencedirect.com/science/article/pii/S2589004225001178natural sciencesbiological sciencesneurosciencebehavioral neuroscience |
| spellingShingle | Cristina Izquierdo-Luengo María Ponce-Renilla Marc Ten-Blanco María Andrea Arnanz Rosa María Tolón Inmaculada Pereda-Pérez Fernando Berrendero Long-term consequences of adolescent exposure to the synthetic cannabinoid AB-FUBINACA in male and female mice iScience natural sciences biological sciences neuroscience behavioral neuroscience |
| title | Long-term consequences of adolescent exposure to the synthetic cannabinoid AB-FUBINACA in male and female mice |
| title_full | Long-term consequences of adolescent exposure to the synthetic cannabinoid AB-FUBINACA in male and female mice |
| title_fullStr | Long-term consequences of adolescent exposure to the synthetic cannabinoid AB-FUBINACA in male and female mice |
| title_full_unstemmed | Long-term consequences of adolescent exposure to the synthetic cannabinoid AB-FUBINACA in male and female mice |
| title_short | Long-term consequences of adolescent exposure to the synthetic cannabinoid AB-FUBINACA in male and female mice |
| title_sort | long term consequences of adolescent exposure to the synthetic cannabinoid ab fubinaca in male and female mice |
| topic | natural sciences biological sciences neuroscience behavioral neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2589004225001178 |
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