Relationship between prognostic nutritional index and asthma: a cross-sectional analysis
Background and objectiveAsthma is a chronic disease characterized by inflammation of the airways. The association between nutritional status, inflammation, and asthma has been well-documented, yet the relationship between the Prognostic Nutritional Index (PNI) and asthma remains unclear. This is a s...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1467270/full |
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| author | Zhimeng Jiang Zhimeng Jiang Xingyu Zhu Xingyu Zhu Huixin Jiang Donglin Zhao Donglin Zhao Jianwei Tian |
| author_facet | Zhimeng Jiang Zhimeng Jiang Xingyu Zhu Xingyu Zhu Huixin Jiang Donglin Zhao Donglin Zhao Jianwei Tian |
| author_sort | Zhimeng Jiang |
| collection | DOAJ |
| description | Background and objectiveAsthma is a chronic disease characterized by inflammation of the airways. The association between nutritional status, inflammation, and asthma has been well-documented, yet the relationship between the Prognostic Nutritional Index (PNI) and asthma remains unclear. This is a study to see whether there is a relationship between PNI and asthma prevalence.MethodsThe present study employed data from the National Health and Nutrition Examination Survey (NHANES) between 2017 and 2020, including a total of 7,869 adult participants were included in the analysis. Participants were categorized into four quartiles based on PNI levels. A multivariable regression model was employed for the purpose of evaluating the correlation between PNI and asthma. In order to ascertain the stability of the association across different populations, subgroup analyses were performed.ResultsHigher PNI levels were significantly associated with lower asthma prevalence. In the complete adjusted model, each additional unit of PNI was associated with a 3% reduction in the prevalence of asthma [0.97 (0.95, 0.99)]. Trend analysis indicated a significant negative correlation between PNI and asthma (p for trend = 0.0041). Subgroup analyses showed a consistent negative association across different populations.ConclusionThe findings of our study indicated that lower PNI values were linked to an elevated odds prevalence of asthma. Early nutritional intervention and inflammation management in high-risk populations with low PNI may reduce the incidence and severity of asthma. Future prospective studies are needed to confirm this relationship. |
| format | Article |
| id | doaj-art-de81e9dca32f476ea8e92d18443ffb0d |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-de81e9dca32f476ea8e92d18443ffb0d2025-02-06T05:21:51ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-02-011210.3389/fnut.2025.14672701467270Relationship between prognostic nutritional index and asthma: a cross-sectional analysisZhimeng Jiang0Zhimeng Jiang1Xingyu Zhu2Xingyu Zhu3Huixin Jiang4Donglin Zhao5Donglin Zhao6Jianwei Tian7Graduate School of Hebei North University, Zhangjiakou, Hebei, ChinaDepartment of Gastroenterology, Air Force Medical Center, Chinese People’s Liberation Army, Beijing, ChinaGraduate School of Hebei North University, Zhangjiakou, Hebei, ChinaDepartment of Cardiovascular Medicine, Air Force Medical Center, Chinese People’s Liberation Army, Beijing, ChinaHaiyuan College of Kunming Medical University, Kunming, Yunnan, ChinaGraduate School of Hebei North University, Zhangjiakou, Hebei, ChinaDepartment of Gastroenterology, Air Force Medical Center, Chinese People’s Liberation Army, Beijing, ChinaDepartment of Cardiovascular Medicine, Air Force Medical Center, Chinese People’s Liberation Army, Beijing, ChinaBackground and objectiveAsthma is a chronic disease characterized by inflammation of the airways. The association between nutritional status, inflammation, and asthma has been well-documented, yet the relationship between the Prognostic Nutritional Index (PNI) and asthma remains unclear. This is a study to see whether there is a relationship between PNI and asthma prevalence.MethodsThe present study employed data from the National Health and Nutrition Examination Survey (NHANES) between 2017 and 2020, including a total of 7,869 adult participants were included in the analysis. Participants were categorized into four quartiles based on PNI levels. A multivariable regression model was employed for the purpose of evaluating the correlation between PNI and asthma. In order to ascertain the stability of the association across different populations, subgroup analyses were performed.ResultsHigher PNI levels were significantly associated with lower asthma prevalence. In the complete adjusted model, each additional unit of PNI was associated with a 3% reduction in the prevalence of asthma [0.97 (0.95, 0.99)]. Trend analysis indicated a significant negative correlation between PNI and asthma (p for trend = 0.0041). Subgroup analyses showed a consistent negative association across different populations.ConclusionThe findings of our study indicated that lower PNI values were linked to an elevated odds prevalence of asthma. Early nutritional intervention and inflammation management in high-risk populations with low PNI may reduce the incidence and severity of asthma. Future prospective studies are needed to confirm this relationship.https://www.frontiersin.org/articles/10.3389/fnut.2025.1467270/fullprognostic nutritional indexasthmanutritional statusinflammatorycross-sectional studyNational Health and Nutrition Examination Survey |
| spellingShingle | Zhimeng Jiang Zhimeng Jiang Xingyu Zhu Xingyu Zhu Huixin Jiang Donglin Zhao Donglin Zhao Jianwei Tian Relationship between prognostic nutritional index and asthma: a cross-sectional analysis Frontiers in Nutrition prognostic nutritional index asthma nutritional status inflammatory cross-sectional study National Health and Nutrition Examination Survey |
| title | Relationship between prognostic nutritional index and asthma: a cross-sectional analysis |
| title_full | Relationship between prognostic nutritional index and asthma: a cross-sectional analysis |
| title_fullStr | Relationship between prognostic nutritional index and asthma: a cross-sectional analysis |
| title_full_unstemmed | Relationship between prognostic nutritional index and asthma: a cross-sectional analysis |
| title_short | Relationship between prognostic nutritional index and asthma: a cross-sectional analysis |
| title_sort | relationship between prognostic nutritional index and asthma a cross sectional analysis |
| topic | prognostic nutritional index asthma nutritional status inflammatory cross-sectional study National Health and Nutrition Examination Survey |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1467270/full |
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