Extra-Axial Hematoma and Trimethoprim-Sulfamethoxazole Induced Aplastic Anemia: The Role of Hematological Diseases in Subdural and Epidural Hemorrhage
Objective and Importance. To illustrate the development of spontaneous subdural hematoma secondary to aplastic anemia resulting from the administration of trimethoprim-sulfamethoxazole. This is the first report of trimethoprim-sulfamethoxazole potentiating coagulopathy leading to any form of intracr...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2015/374951 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832550173605101568 |
|---|---|
| author | Richard P. Menger Rimal H. Dossani Jai Deep Thakur Frank Farokhi Kevin Morrow Bharat Guthikonda |
| author_facet | Richard P. Menger Rimal H. Dossani Jai Deep Thakur Frank Farokhi Kevin Morrow Bharat Guthikonda |
| author_sort | Richard P. Menger |
| collection | DOAJ |
| description | Objective and Importance. To illustrate the development of spontaneous subdural hematoma secondary to aplastic anemia resulting from the administration of trimethoprim-sulfamethoxazole. This is the first report of trimethoprim-sulfamethoxazole potentiating coagulopathy leading to any form of intracranial hematoma. Clinical Presentation. A 62-year-old female developed a bone marrow biopsy confirmed diagnosis of aplastic anemia secondary to administration of trimethoprim-sulfamethoxazole following a canine bite. She then developed a course of waxing and waning mental status combined with headache and balance related falls. CT imaging of the head illustrated a 3.7 cm × 6.6 mm left frontal subdural hematoma combined with a 7.0 mm × 1.7 cm left temporal epidural hematoma. Conclusion. Aplastic anemia is a rare complication of the administration of trimethoprim-sulfamethoxazole. Thrombocytopenia, regardless of cause, is a risk factor for the development of spontaneous subdural hematoma. Given the lack of a significant traumatic mechanism, this subset of subdural hematoma is more suitable to conservative management. |
| format | Article |
| id | doaj-art-de6be243f3724dc78167b36c399b03b5 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-de6be243f3724dc78167b36c399b03b52025-02-03T06:07:30ZengWileyCase Reports in Hematology2090-65602090-65792015-01-01201510.1155/2015/374951374951Extra-Axial Hematoma and Trimethoprim-Sulfamethoxazole Induced Aplastic Anemia: The Role of Hematological Diseases in Subdural and Epidural HemorrhageRichard P. Menger0Rimal H. Dossani1Jai Deep Thakur2Frank Farokhi3Kevin Morrow4Bharat Guthikonda5Department of Neurosurgery, LSU Health Sciences Center-Shreveport, 1501 Kings Highway, P.O. Box 33932, Shreveport, LA 71130-3932, USADepartment of Neurosurgery, LSU Health Sciences Center-Shreveport, 1501 Kings Highway, P.O. Box 33932, Shreveport, LA 71130-3932, USADepartment of Neurosurgery, LSU Health Sciences Center-Shreveport, 1501 Kings Highway, P.O. Box 33932, Shreveport, LA 71130-3932, USADepartment of Neurosurgery, LSU Health Sciences Center-Shreveport, 1501 Kings Highway, P.O. Box 33932, Shreveport, LA 71130-3932, USADepartment of Neurosurgery, LSU Health Sciences Center-Shreveport, 1501 Kings Highway, P.O. Box 33932, Shreveport, LA 71130-3932, USADepartment of Neurosurgery, LSU Health Sciences Center-Shreveport, 1501 Kings Highway, P.O. Box 33932, Shreveport, LA 71130-3932, USAObjective and Importance. To illustrate the development of spontaneous subdural hematoma secondary to aplastic anemia resulting from the administration of trimethoprim-sulfamethoxazole. This is the first report of trimethoprim-sulfamethoxazole potentiating coagulopathy leading to any form of intracranial hematoma. Clinical Presentation. A 62-year-old female developed a bone marrow biopsy confirmed diagnosis of aplastic anemia secondary to administration of trimethoprim-sulfamethoxazole following a canine bite. She then developed a course of waxing and waning mental status combined with headache and balance related falls. CT imaging of the head illustrated a 3.7 cm × 6.6 mm left frontal subdural hematoma combined with a 7.0 mm × 1.7 cm left temporal epidural hematoma. Conclusion. Aplastic anemia is a rare complication of the administration of trimethoprim-sulfamethoxazole. Thrombocytopenia, regardless of cause, is a risk factor for the development of spontaneous subdural hematoma. Given the lack of a significant traumatic mechanism, this subset of subdural hematoma is more suitable to conservative management.http://dx.doi.org/10.1155/2015/374951 |
| spellingShingle | Richard P. Menger Rimal H. Dossani Jai Deep Thakur Frank Farokhi Kevin Morrow Bharat Guthikonda Extra-Axial Hematoma and Trimethoprim-Sulfamethoxazole Induced Aplastic Anemia: The Role of Hematological Diseases in Subdural and Epidural Hemorrhage Case Reports in Hematology |
| title | Extra-Axial Hematoma and Trimethoprim-Sulfamethoxazole Induced Aplastic Anemia: The Role of Hematological Diseases in Subdural and Epidural Hemorrhage |
| title_full | Extra-Axial Hematoma and Trimethoprim-Sulfamethoxazole Induced Aplastic Anemia: The Role of Hematological Diseases in Subdural and Epidural Hemorrhage |
| title_fullStr | Extra-Axial Hematoma and Trimethoprim-Sulfamethoxazole Induced Aplastic Anemia: The Role of Hematological Diseases in Subdural and Epidural Hemorrhage |
| title_full_unstemmed | Extra-Axial Hematoma and Trimethoprim-Sulfamethoxazole Induced Aplastic Anemia: The Role of Hematological Diseases in Subdural and Epidural Hemorrhage |
| title_short | Extra-Axial Hematoma and Trimethoprim-Sulfamethoxazole Induced Aplastic Anemia: The Role of Hematological Diseases in Subdural and Epidural Hemorrhage |
| title_sort | extra axial hematoma and trimethoprim sulfamethoxazole induced aplastic anemia the role of hematological diseases in subdural and epidural hemorrhage |
| url | http://dx.doi.org/10.1155/2015/374951 |
| work_keys_str_mv | AT richardpmenger extraaxialhematomaandtrimethoprimsulfamethoxazoleinducedaplasticanemiatheroleofhematologicaldiseasesinsubduralandepiduralhemorrhage AT rimalhdossani extraaxialhematomaandtrimethoprimsulfamethoxazoleinducedaplasticanemiatheroleofhematologicaldiseasesinsubduralandepiduralhemorrhage AT jaideepthakur extraaxialhematomaandtrimethoprimsulfamethoxazoleinducedaplasticanemiatheroleofhematologicaldiseasesinsubduralandepiduralhemorrhage AT frankfarokhi extraaxialhematomaandtrimethoprimsulfamethoxazoleinducedaplasticanemiatheroleofhematologicaldiseasesinsubduralandepiduralhemorrhage AT kevinmorrow extraaxialhematomaandtrimethoprimsulfamethoxazoleinducedaplasticanemiatheroleofhematologicaldiseasesinsubduralandepiduralhemorrhage AT bharatguthikonda extraaxialhematomaandtrimethoprimsulfamethoxazoleinducedaplasticanemiatheroleofhematologicaldiseasesinsubduralandepiduralhemorrhage |