Application and prospect analysis of chimeric antigen receptor T-cell therapy in hepatocellular carcinoma treatment: a systematic review and meta-analysis

Application and prospect analysis of chimeric antigen receptor T-cell therapy in hepatocellular carcinoma treatment: a systematic review and meta-analysis

IntroductionHepatocellular carcinoma (HCC), accounting for 90% of primary liver cancers, is a high-mortality malignancy and the third leading cause of cancer-related deaths globally, with major risk factors like hepatitis B/C, aflatoxin exposure, and obesity. Most patients are diagnosed at advanced...

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Bibliographic Details
Main Authors: Sichang Wu, Xinli Gan, Shuxin Huang, Yujun Zhong, Jialin Wu, Haojie Yang, Bangde Xiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
CAR-T therapy
hepatocellular carcinoma
immunotherapy
meta-analysis
systematic review
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1566976/full
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