GRK6 palmitoylation dictates triple-negative breast cancer metastasis via recruiting the β-Arrestin 2/MAPKs/NF-κB signaling axis

GRK6 palmitoylation dictates triple-negative breast cancer metastasis via recruiting the β-Arrestin 2/MAPKs/NF-κB signaling axis

Abstract Background Triple negative breast cancer (TNBC) belongs to the worst prognosis of breast cancer subtype probably because of distant metastasis to other organs, e.g. lungs. However, the mechanism underlying TNBC metastasis remains largely unknown. Methods Bioinformatics analysis was conducte...

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Main Authors: Wen-Ke Wang, Hui-Yu Lin, Che-Hsuan Lin, Hsun-Hua Lee, Yen-Lin Chen, Yu-Hsien Kent Lin, Hui-Wen Chiu, Shry-Ming Sheen-Chen, Yuan-Feng Lin
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Breast Cancer Research
Subjects:
Triple-negative breast cancer
Metastasis
GRK6
β-Arrestin 2
MAPKs
NF-κB
Online Access:https://doi.org/10.1186/s13058-024-01953-z
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