Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease
Type 2 diabetes (T2DM), Alzheimer’s disease (AD), and insulin resistance are age-related conditions and increased prevalence is of public concern. Recent research has provided evidence that insulin resistance and impaired insulin signalling may be a contributory factor to the progression of diabetes...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/105828 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832550774427615232 |
|---|---|
| author | Giuseppe Verdile Kevin N. Keane Vinicius F. Cruzat Sandra Medic Miheer Sabale Joanne Rowles Nadeeja Wijesekara Ralph N. Martins Paul E. Fraser Philip Newsholme |
| author_facet | Giuseppe Verdile Kevin N. Keane Vinicius F. Cruzat Sandra Medic Miheer Sabale Joanne Rowles Nadeeja Wijesekara Ralph N. Martins Paul E. Fraser Philip Newsholme |
| author_sort | Giuseppe Verdile |
| collection | DOAJ |
| description | Type 2 diabetes (T2DM), Alzheimer’s disease (AD), and insulin resistance are age-related conditions and increased prevalence is of public concern. Recent research has provided evidence that insulin resistance and impaired insulin signalling may be a contributory factor to the progression of diabetes, dementia, and other neurological disorders. Alzheimer’s disease (AD) is the most common subtype of dementia. Reduced release (for T2DM) and decreased action of insulin are central to the development and progression of both T2DM and AD. A literature search was conducted to identify molecular commonalities between obesity, diabetes, and AD. Insulin resistance affects many tissues and organs, either through impaired insulin signalling or through aberrant changes in both glucose and lipid (cholesterol and triacylglycerol) metabolism and concentrations in the blood. Although epidemiological and biological evidence has highlighted an increased incidence of cognitive decline and AD in patients with T2DM, the common molecular basis of cell and tissue dysfunction is rapidly gaining recognition. As a cause or consequence, the chronic inflammatory response and oxidative stress associated with T2DM, amyloid-β (Aβ) protein accumulation, and mitochondrial dysfunction link T2DM and AD. |
| format | Article |
| id | doaj-art-de65fd2b05df46b59967626a085fe815 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-de65fd2b05df46b59967626a085fe8152025-02-03T06:05:53ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/105828105828Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s DiseaseGiuseppe Verdile0Kevin N. Keane1Vinicius F. Cruzat2Sandra Medic3Miheer Sabale4Joanne Rowles5Nadeeja Wijesekara6Ralph N. Martins7Paul E. Fraser8Philip Newsholme9School of Biomedical Sciences, Curtin Health Innovation Research Institute, Biosciences, Curtin University, Kent Street, Bentley, Perth, WA 6102, AustraliaSchool of Biomedical Sciences, Curtin Health Innovation Research Institute, Biosciences, Curtin University, Kent Street, Bentley, Perth, WA 6102, AustraliaSchool of Biomedical Sciences, Curtin Health Innovation Research Institute, Biosciences, Curtin University, Kent Street, Bentley, Perth, WA 6102, AustraliaSchool of Biomedical Sciences, Curtin Health Innovation Research Institute, Biosciences, Curtin University, Kent Street, Bentley, Perth, WA 6102, AustraliaSchool of Biomedical Sciences, Curtin Health Innovation Research Institute, Biosciences, Curtin University, Kent Street, Bentley, Perth, WA 6102, AustraliaSchool of Biomedical Sciences, Curtin Health Innovation Research Institute, Biosciences, Curtin University, Kent Street, Bentley, Perth, WA 6102, AustraliaUniversity of Toronto, Tanz Centre for Research in Neurodegenerative Diseases, Department of Medical Biophysics, Krembil Discovery Tower, 60 Leonard Avenue, Toronto, ON, M5T 2S8, CanadaCentre of Excellence for Alzheimer’s Disease Research and Care, School of Medical Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, Perth, WA 6027, AustraliaUniversity of Toronto, Tanz Centre for Research in Neurodegenerative Diseases, Department of Medical Biophysics, Krembil Discovery Tower, 60 Leonard Avenue, Toronto, ON, M5T 2S8, CanadaSchool of Biomedical Sciences, Curtin Health Innovation Research Institute, Biosciences, Curtin University, Kent Street, Bentley, Perth, WA 6102, AustraliaType 2 diabetes (T2DM), Alzheimer’s disease (AD), and insulin resistance are age-related conditions and increased prevalence is of public concern. Recent research has provided evidence that insulin resistance and impaired insulin signalling may be a contributory factor to the progression of diabetes, dementia, and other neurological disorders. Alzheimer’s disease (AD) is the most common subtype of dementia. Reduced release (for T2DM) and decreased action of insulin are central to the development and progression of both T2DM and AD. A literature search was conducted to identify molecular commonalities between obesity, diabetes, and AD. Insulin resistance affects many tissues and organs, either through impaired insulin signalling or through aberrant changes in both glucose and lipid (cholesterol and triacylglycerol) metabolism and concentrations in the blood. Although epidemiological and biological evidence has highlighted an increased incidence of cognitive decline and AD in patients with T2DM, the common molecular basis of cell and tissue dysfunction is rapidly gaining recognition. As a cause or consequence, the chronic inflammatory response and oxidative stress associated with T2DM, amyloid-β (Aβ) protein accumulation, and mitochondrial dysfunction link T2DM and AD.http://dx.doi.org/10.1155/2015/105828 |
| spellingShingle | Giuseppe Verdile Kevin N. Keane Vinicius F. Cruzat Sandra Medic Miheer Sabale Joanne Rowles Nadeeja Wijesekara Ralph N. Martins Paul E. Fraser Philip Newsholme Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease Mediators of Inflammation |
| title | Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease |
| title_full | Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease |
| title_fullStr | Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease |
| title_full_unstemmed | Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease |
| title_short | Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease |
| title_sort | inflammation and oxidative stress the molecular connectivity between insulin resistance obesity and alzheimer s disease |
| url | http://dx.doi.org/10.1155/2015/105828 |
| work_keys_str_mv | AT giuseppeverdile inflammationandoxidativestressthemolecularconnectivitybetweeninsulinresistanceobesityandalzheimersdisease AT kevinnkeane inflammationandoxidativestressthemolecularconnectivitybetweeninsulinresistanceobesityandalzheimersdisease AT viniciusfcruzat inflammationandoxidativestressthemolecularconnectivitybetweeninsulinresistanceobesityandalzheimersdisease AT sandramedic inflammationandoxidativestressthemolecularconnectivitybetweeninsulinresistanceobesityandalzheimersdisease AT miheersabale inflammationandoxidativestressthemolecularconnectivitybetweeninsulinresistanceobesityandalzheimersdisease AT joannerowles inflammationandoxidativestressthemolecularconnectivitybetweeninsulinresistanceobesityandalzheimersdisease AT nadeejawijesekara inflammationandoxidativestressthemolecularconnectivitybetweeninsulinresistanceobesityandalzheimersdisease AT ralphnmartins inflammationandoxidativestressthemolecularconnectivitybetweeninsulinresistanceobesityandalzheimersdisease AT paulefraser inflammationandoxidativestressthemolecularconnectivitybetweeninsulinresistanceobesityandalzheimersdisease AT philipnewsholme inflammationandoxidativestressthemolecularconnectivitybetweeninsulinresistanceobesityandalzheimersdisease |