Gingival Mesenchymal Stem/Progenitor Cells: A Unique Tissue Engineering Gem
The human gingiva, characterized by its outstanding scarless wound healing properties, is a unique tissue and a pivotal component of the periodontal apparatus, investing and surrounding the teeth in their sockets in the alveolar bone. In the last years gingival mesenchymal stem/progenitor cells (G-M...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/7154327 |
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| author | Karim M. Fawzy El-Sayed Christof E. Dörfer |
| author_facet | Karim M. Fawzy El-Sayed Christof E. Dörfer |
| author_sort | Karim M. Fawzy El-Sayed |
| collection | DOAJ |
| description | The human gingiva, characterized by its outstanding scarless wound healing properties, is a unique tissue and a pivotal component of the periodontal apparatus, investing and surrounding the teeth in their sockets in the alveolar bone. In the last years gingival mesenchymal stem/progenitor cells (G-MSCs), with promising regenerative and immunomodulatory properties, have been isolated and characterized from the gingival lamina propria. These cells, in contrast to other mesenchymal stem/progenitor cell sources, are abundant, readily accessible, and easily obtainable via minimally invasive cell isolation techniques. The present review summarizes the current scientific evidence on G-MSCs’ isolation, their characterization, the investigated subpopulations, the generated induced pluripotent stem cells- (iPSC-) like G-MSCs, their regenerative properties, and current approaches for G-MSCs’ delivery. The review further demonstrates their immunomodulatory properties, the transplantation preconditioning attempts via multiple biomolecules to enhance their attributes, and the experimental therapeutic applications conducted to treat multiple diseases in experimental animal models in vivo. G-MSCs show remarkable tissue reparative/regenerative potential, noteworthy immunomodulatory properties, and primary experimental therapeutic applications of G-MSCs are very promising, pointing at future biologically based therapeutic techniques, being potentially superior to conventional clinical treatment modalities. |
| format | Article |
| id | doaj-art-de63644cf8494593864c08059640e481 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-de63644cf8494593864c08059640e4812025-02-03T01:09:25ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/71543277154327Gingival Mesenchymal Stem/Progenitor Cells: A Unique Tissue Engineering GemKarim M. Fawzy El-Sayed0Christof E. Dörfer1Clinic of Conservative Dentistry and Periodontology, Christian Albrechts University of Kiel, Arnold Heller Straße 3, Haus 26, 24105 Kiel, GermanyClinic of Conservative Dentistry and Periodontology, Christian Albrechts University of Kiel, Arnold Heller Straße 3, Haus 26, 24105 Kiel, GermanyThe human gingiva, characterized by its outstanding scarless wound healing properties, is a unique tissue and a pivotal component of the periodontal apparatus, investing and surrounding the teeth in their sockets in the alveolar bone. In the last years gingival mesenchymal stem/progenitor cells (G-MSCs), with promising regenerative and immunomodulatory properties, have been isolated and characterized from the gingival lamina propria. These cells, in contrast to other mesenchymal stem/progenitor cell sources, are abundant, readily accessible, and easily obtainable via minimally invasive cell isolation techniques. The present review summarizes the current scientific evidence on G-MSCs’ isolation, their characterization, the investigated subpopulations, the generated induced pluripotent stem cells- (iPSC-) like G-MSCs, their regenerative properties, and current approaches for G-MSCs’ delivery. The review further demonstrates their immunomodulatory properties, the transplantation preconditioning attempts via multiple biomolecules to enhance their attributes, and the experimental therapeutic applications conducted to treat multiple diseases in experimental animal models in vivo. G-MSCs show remarkable tissue reparative/regenerative potential, noteworthy immunomodulatory properties, and primary experimental therapeutic applications of G-MSCs are very promising, pointing at future biologically based therapeutic techniques, being potentially superior to conventional clinical treatment modalities.http://dx.doi.org/10.1155/2016/7154327 |
| spellingShingle | Karim M. Fawzy El-Sayed Christof E. Dörfer Gingival Mesenchymal Stem/Progenitor Cells: A Unique Tissue Engineering Gem Stem Cells International |
| title | Gingival Mesenchymal Stem/Progenitor Cells: A Unique Tissue Engineering Gem |
| title_full | Gingival Mesenchymal Stem/Progenitor Cells: A Unique Tissue Engineering Gem |
| title_fullStr | Gingival Mesenchymal Stem/Progenitor Cells: A Unique Tissue Engineering Gem |
| title_full_unstemmed | Gingival Mesenchymal Stem/Progenitor Cells: A Unique Tissue Engineering Gem |
| title_short | Gingival Mesenchymal Stem/Progenitor Cells: A Unique Tissue Engineering Gem |
| title_sort | gingival mesenchymal stem progenitor cells a unique tissue engineering gem |
| url | http://dx.doi.org/10.1155/2016/7154327 |
| work_keys_str_mv | AT karimmfawzyelsayed gingivalmesenchymalstemprogenitorcellsauniquetissueengineeringgem AT christofedorfer gingivalmesenchymalstemprogenitorcellsauniquetissueengineeringgem |