GC Method Validation for the Analysis of Menthol in Suppository Pharmaceutical Dosage Form
Menthol is widely used as a fragrance and flavor in the food and cosmetic industries. It is also used in the medical and pharmaceutical fields for its various biological effects. Gas chromatography (GC) is considered to be a sensitive method for the analysis of menthol. GC chromatographic separation...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
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| Series: | International Journal of Analytical Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2017/1728414 |
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| _version_ | 1832547606250651648 |
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| author | Murad N. Abualhasan Abdel Naser Zaid Nidal Jaradat Ayman Mousa |
| author_facet | Murad N. Abualhasan Abdel Naser Zaid Nidal Jaradat Ayman Mousa |
| author_sort | Murad N. Abualhasan |
| collection | DOAJ |
| description | Menthol is widely used as a fragrance and flavor in the food and cosmetic industries. It is also used in the medical and pharmaceutical fields for its various biological effects. Gas chromatography (GC) is considered to be a sensitive method for the analysis of menthol. GC chromatographic separation was developed using capillary column (VF-624) and a flame ionization detector (FID). The method was validated as per ICH guidelines for various parameters such as precision, linearity, accuracy, solution stability, robustness, limit of detection, and quantification. The tested validation parameters were found to be within acceptable limits. The method was successfully applied for the quantification of menthol in suppositories formulations. Quality control departments and official pharmacopeias can use our developed method in the analysis of menthol in pharmaceutical dosage formulation and raw material. |
| format | Article |
| id | doaj-art-de55bccdaf14421fa097af8e123f83fa |
| institution | Kabale University |
| issn | 1687-8760 1687-8779 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Analytical Chemistry |
| spelling | doaj-art-de55bccdaf14421fa097af8e123f83fa2025-02-03T06:44:15ZengWileyInternational Journal of Analytical Chemistry1687-87601687-87792017-01-01201710.1155/2017/17284141728414GC Method Validation for the Analysis of Menthol in Suppository Pharmaceutical Dosage FormMurad N. Abualhasan0Abdel Naser Zaid1Nidal Jaradat2Ayman Mousa3Department of Pharmacy, Faculty of Medicine & Health Sciences, An Najah National University, Nablus, State of PalestineDepartment of Pharmacy, Faculty of Medicine & Health Sciences, An Najah National University, Nablus, State of PalestineDepartment of Pharmacy, Faculty of Medicine & Health Sciences, An Najah National University, Nablus, State of PalestineR&D Department, Avalon Pharma, Riyadh, Saudi ArabiaMenthol is widely used as a fragrance and flavor in the food and cosmetic industries. It is also used in the medical and pharmaceutical fields for its various biological effects. Gas chromatography (GC) is considered to be a sensitive method for the analysis of menthol. GC chromatographic separation was developed using capillary column (VF-624) and a flame ionization detector (FID). The method was validated as per ICH guidelines for various parameters such as precision, linearity, accuracy, solution stability, robustness, limit of detection, and quantification. The tested validation parameters were found to be within acceptable limits. The method was successfully applied for the quantification of menthol in suppositories formulations. Quality control departments and official pharmacopeias can use our developed method in the analysis of menthol in pharmaceutical dosage formulation and raw material.http://dx.doi.org/10.1155/2017/1728414 |
| spellingShingle | Murad N. Abualhasan Abdel Naser Zaid Nidal Jaradat Ayman Mousa GC Method Validation for the Analysis of Menthol in Suppository Pharmaceutical Dosage Form International Journal of Analytical Chemistry |
| title | GC Method Validation for the Analysis of Menthol in Suppository Pharmaceutical Dosage Form |
| title_full | GC Method Validation for the Analysis of Menthol in Suppository Pharmaceutical Dosage Form |
| title_fullStr | GC Method Validation for the Analysis of Menthol in Suppository Pharmaceutical Dosage Form |
| title_full_unstemmed | GC Method Validation for the Analysis of Menthol in Suppository Pharmaceutical Dosage Form |
| title_short | GC Method Validation for the Analysis of Menthol in Suppository Pharmaceutical Dosage Form |
| title_sort | gc method validation for the analysis of menthol in suppository pharmaceutical dosage form |
| url | http://dx.doi.org/10.1155/2017/1728414 |
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