Evaluation of Halogenated Coumarins for Antimosquito Properties
Mosquitoes are the major vectors of parasites and pathogens affecting humans and domestic animals. The widespread development of insecticide resistance and negative environmental effects of most synthetic compounds support an interest in finding and developing alternative products against mosquitoes...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/189824 |
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| author | Venugopala K. Narayanaswamy Raquel M. Gleiser Kabange Kasumbwe Bandar E. Aldhubiab Mahesh V. Attimarad Bharti Odhav |
| author_facet | Venugopala K. Narayanaswamy Raquel M. Gleiser Kabange Kasumbwe Bandar E. Aldhubiab Mahesh V. Attimarad Bharti Odhav |
| author_sort | Venugopala K. Narayanaswamy |
| collection | DOAJ |
| description | Mosquitoes are the major vectors of parasites and pathogens affecting humans and domestic animals. The widespread development of insecticide resistance and negative environmental effects of most synthetic compounds support an interest in finding and developing alternative products against mosquitoes. Natural coumarins and synthetic coumarin analogues are known for their several pharmacological properties, including being insecticidal. In the present study halogenated coumarins (3-mono/dibromo acetyl, 6-halogenated coumarin analogues) were screened for larvicidal, adulticidal, and repellent properties against Anopheles arabiensis, a zoophilic mosquito that is one of the dominant vectors of malaria in Africa. Five compounds exerted 100% larval mortality within 24 h of exposure. All coumarins and halogenated coumarins reversibly knocked down adult mosquitoes but did not kill them after 24 h of exposure. Repellent properties could not be evidenced. Five compounds were considered potential larvicidal agents for further research and development, while adulticidal activity was considered only mild to moderate. |
| format | Article |
| id | doaj-art-de43f97f8d874a84896a03435f58bd72 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-de43f97f8d874a84896a03435f58bd722025-02-03T05:46:12ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/189824189824Evaluation of Halogenated Coumarins for Antimosquito PropertiesVenugopala K. Narayanaswamy0Raquel M. Gleiser1Kabange Kasumbwe2Bandar E. Aldhubiab3Mahesh V. Attimarad4Bharti Odhav5Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi ArabiaCREAN-IMBIV (CONICET-UNC), Facultad de Ciencias Agropecuarias, and FCEFyN, Universidad Nacional de Córdoba, Avenida Valparaíso s/n, 5016 Córdoba, ArgentinaDepartment of Biotechnology and Food Technology, Durban University of Technology, Durban 4001, South AfricaDepartment of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Biotechnology and Food Technology, Durban University of Technology, Durban 4001, South AfricaMosquitoes are the major vectors of parasites and pathogens affecting humans and domestic animals. The widespread development of insecticide resistance and negative environmental effects of most synthetic compounds support an interest in finding and developing alternative products against mosquitoes. Natural coumarins and synthetic coumarin analogues are known for their several pharmacological properties, including being insecticidal. In the present study halogenated coumarins (3-mono/dibromo acetyl, 6-halogenated coumarin analogues) were screened for larvicidal, adulticidal, and repellent properties against Anopheles arabiensis, a zoophilic mosquito that is one of the dominant vectors of malaria in Africa. Five compounds exerted 100% larval mortality within 24 h of exposure. All coumarins and halogenated coumarins reversibly knocked down adult mosquitoes but did not kill them after 24 h of exposure. Repellent properties could not be evidenced. Five compounds were considered potential larvicidal agents for further research and development, while adulticidal activity was considered only mild to moderate.http://dx.doi.org/10.1155/2014/189824 |
| spellingShingle | Venugopala K. Narayanaswamy Raquel M. Gleiser Kabange Kasumbwe Bandar E. Aldhubiab Mahesh V. Attimarad Bharti Odhav Evaluation of Halogenated Coumarins for Antimosquito Properties The Scientific World Journal |
| title | Evaluation of Halogenated Coumarins for Antimosquito Properties |
| title_full | Evaluation of Halogenated Coumarins for Antimosquito Properties |
| title_fullStr | Evaluation of Halogenated Coumarins for Antimosquito Properties |
| title_full_unstemmed | Evaluation of Halogenated Coumarins for Antimosquito Properties |
| title_short | Evaluation of Halogenated Coumarins for Antimosquito Properties |
| title_sort | evaluation of halogenated coumarins for antimosquito properties |
| url | http://dx.doi.org/10.1155/2014/189824 |
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