The Biological and Metabolic Fates of Endogenous DNA Damage Products
DNA and other biomolecules are subjected to damaging chemical reactions during normal physiological processes and in states of pathophysiology caused by endogenous and exogenous mechanisms. In DNA, this damage affects both the nucleobases and 2-deoxyribose, with a host of damage products that refle...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Journal of Nucleic Acids |
| Online Access: | http://dx.doi.org/10.4061/2010/929047 |
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| _version_ | 1832556987286552576 |
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| author | Simon Wan Chan Peter C. Dedon |
| author_facet | Simon Wan Chan Peter C. Dedon |
| author_sort | Simon Wan Chan |
| collection | DOAJ |
| description | DNA and other biomolecules are subjected to damaging chemical reactions during normal physiological processes and in states of pathophysiology caused by endogenous and exogenous mechanisms. In DNA, this damage affects both the nucleobases and 2-deoxyribose, with a host of damage products that reflect the local chemical pathology such as oxidative stress and inflammation. These damaged molecules represent a potential source of biomarkers for defining mechanisms of pathology, quantifying the risk of human disease and studying interindividual variations in cellular repair pathways. Toward the goal of developing biomarkers, significant effort has been made to detect and quantify damage biomolecules in clinically accessible compartments such as blood and and urine. However, there has been little effort to define the biotransformational fate of damaged biomolecules as they move from the site of formation to excretion in clinically accessible compartments. This paper highlights examples of this important problem with DNA damage products. |
| format | Article |
| id | doaj-art-de3d40746aa44cd7849431a5ecaed2d5 |
| institution | Kabale University |
| issn | 2090-021X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nucleic Acids |
| spelling | doaj-art-de3d40746aa44cd7849431a5ecaed2d52025-02-03T05:43:53ZengWileyJournal of Nucleic Acids2090-021X2010-01-01201010.4061/2010/929047929047The Biological and Metabolic Fates of Endogenous DNA Damage ProductsSimon Wan Chan0Peter C. Dedon1Department of Biological Engineering, Massachusetts Institute of Technology, NE47-277, Cambridge, MA 02139, USADepartment of Biological Engineering, Massachusetts Institute of Technology, NE47-277, Cambridge, MA 02139, USADNA and other biomolecules are subjected to damaging chemical reactions during normal physiological processes and in states of pathophysiology caused by endogenous and exogenous mechanisms. In DNA, this damage affects both the nucleobases and 2-deoxyribose, with a host of damage products that reflect the local chemical pathology such as oxidative stress and inflammation. These damaged molecules represent a potential source of biomarkers for defining mechanisms of pathology, quantifying the risk of human disease and studying interindividual variations in cellular repair pathways. Toward the goal of developing biomarkers, significant effort has been made to detect and quantify damage biomolecules in clinically accessible compartments such as blood and and urine. However, there has been little effort to define the biotransformational fate of damaged biomolecules as they move from the site of formation to excretion in clinically accessible compartments. This paper highlights examples of this important problem with DNA damage products.http://dx.doi.org/10.4061/2010/929047 |
| spellingShingle | Simon Wan Chan Peter C. Dedon The Biological and Metabolic Fates of Endogenous DNA Damage Products Journal of Nucleic Acids |
| title | The Biological and Metabolic Fates of Endogenous DNA Damage Products |
| title_full | The Biological and Metabolic Fates of Endogenous DNA Damage Products |
| title_fullStr | The Biological and Metabolic Fates of Endogenous DNA Damage Products |
| title_full_unstemmed | The Biological and Metabolic Fates of Endogenous DNA Damage Products |
| title_short | The Biological and Metabolic Fates of Endogenous DNA Damage Products |
| title_sort | biological and metabolic fates of endogenous dna damage products |
| url | http://dx.doi.org/10.4061/2010/929047 |
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