Spinal neuron-glial crosstalk and ion channel dysregulation in diabetic neuropathic pain

Spinal neuron-glial crosstalk and ion channel dysregulation in diabetic neuropathic pain

Diabetic neuropathic pain (DNP) is one of the most prevalent complications of diabetes, characterized by a high global prevalence and a substantial affected population with limited effective therapeutic options. Although DNP is closely associated with hyperglycemia, an increasing body of research su...

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Bibliographic Details
Main Authors: Jie Wu, Haijun Hu, Xi Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
diabetic neuropathic pain
microglia
astrocytes
Schwann cells
ion channels
spinal dorsal horn
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1480534/full
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