Artemisinin-Based Combination Therapy Depressed Mitosis and Induced Chromosome Aberration in Onion Root Cells
Artemisinin-based combination therapy is used to treat uncomplicated malaria disease in most endemic countries. Although most antimalarial drugs are effective in killing the parasite, there is a concern of induced toxicity to the cell. Here, the cytogenotoxicity of dihydroartemisinin-piperaquine pho...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2018/4671326 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832555497898639360 |
|---|---|
| author | J. I. Raji C. K. Onwuamah P. G. C. Odeigah |
| author_facet | J. I. Raji C. K. Onwuamah P. G. C. Odeigah |
| author_sort | J. I. Raji |
| collection | DOAJ |
| description | Artemisinin-based combination therapy is used to treat uncomplicated malaria disease in most endemic countries. Although most antimalarial drugs are effective in killing the parasite, there is a concern of induced toxicity to the cell. Here, the cytogenotoxicity of dihydroartemisinin-piperaquine phosphate (DHAP), a coformulation for artemisinin-based combination therapy, was evaluated using Allium cepa model. The toxicity on the mitotic index varies with the duration of exposure and dose tested. Chromosome aberrations observed include chromosome fragments, chromosome bridges, binucleated cells, and micronucleated cells. This study showed that DHAP can depress mitosis and induce chromosome abnormalities. Their accumulation in cells may be inhibitory to cell division and growth. This calls for caution in the administration of artemisinin combination therapy for the treatment of malaria ailment. Wide spacing of dosage is therefore suggested in order to avoid the risk of genetic damage. |
| format | Article |
| id | doaj-art-de0c3ac650254c3287a0c1440b774fe8 |
| institution | Kabale University |
| issn | 1687-8191 1687-8205 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-de0c3ac650254c3287a0c1440b774fe82025-02-03T05:48:07ZengWileyJournal of Toxicology1687-81911687-82052018-01-01201810.1155/2018/46713264671326Artemisinin-Based Combination Therapy Depressed Mitosis and Induced Chromosome Aberration in Onion Root CellsJ. I. Raji0C. K. Onwuamah1P. G. C. Odeigah2Department of Cell Biology and Genetics, University of Lagos, NigeriaCentre for Human Virology and Genomics, Nigerian Institute of Medical Research, Lagos, NigeriaDepartment of Cell Biology and Genetics, University of Lagos, NigeriaArtemisinin-based combination therapy is used to treat uncomplicated malaria disease in most endemic countries. Although most antimalarial drugs are effective in killing the parasite, there is a concern of induced toxicity to the cell. Here, the cytogenotoxicity of dihydroartemisinin-piperaquine phosphate (DHAP), a coformulation for artemisinin-based combination therapy, was evaluated using Allium cepa model. The toxicity on the mitotic index varies with the duration of exposure and dose tested. Chromosome aberrations observed include chromosome fragments, chromosome bridges, binucleated cells, and micronucleated cells. This study showed that DHAP can depress mitosis and induce chromosome abnormalities. Their accumulation in cells may be inhibitory to cell division and growth. This calls for caution in the administration of artemisinin combination therapy for the treatment of malaria ailment. Wide spacing of dosage is therefore suggested in order to avoid the risk of genetic damage.http://dx.doi.org/10.1155/2018/4671326 |
| spellingShingle | J. I. Raji C. K. Onwuamah P. G. C. Odeigah Artemisinin-Based Combination Therapy Depressed Mitosis and Induced Chromosome Aberration in Onion Root Cells Journal of Toxicology |
| title | Artemisinin-Based Combination Therapy Depressed Mitosis and Induced Chromosome Aberration in Onion Root Cells |
| title_full | Artemisinin-Based Combination Therapy Depressed Mitosis and Induced Chromosome Aberration in Onion Root Cells |
| title_fullStr | Artemisinin-Based Combination Therapy Depressed Mitosis and Induced Chromosome Aberration in Onion Root Cells |
| title_full_unstemmed | Artemisinin-Based Combination Therapy Depressed Mitosis and Induced Chromosome Aberration in Onion Root Cells |
| title_short | Artemisinin-Based Combination Therapy Depressed Mitosis and Induced Chromosome Aberration in Onion Root Cells |
| title_sort | artemisinin based combination therapy depressed mitosis and induced chromosome aberration in onion root cells |
| url | http://dx.doi.org/10.1155/2018/4671326 |
| work_keys_str_mv | AT jiraji artemisininbasedcombinationtherapydepressedmitosisandinducedchromosomeaberrationinonionrootcells AT ckonwuamah artemisininbasedcombinationtherapydepressedmitosisandinducedchromosomeaberrationinonionrootcells AT pgcodeigah artemisininbasedcombinationtherapydepressedmitosisandinducedchromosomeaberrationinonionrootcells |