The involvement of vitamin D in the pathogenesis of anxiety and depression in benign paroxysmal positional vertigo comorbidities
We review the potential effects and mechanisms of vitamin D (VD) in patients with BPPV-associated anxiety and depression, offering a new perspective for treating the population. Methods: Through a systematic review of existing literature, we analyzed the relationship between VD and comorbid anxiety...
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| Format: | Article |
| Language: | English |
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World Scientific Publishing
2024-01-01
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| Series: | Traditional Medicine and Modern Medicine |
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| Online Access: | https://www.worldscientific.com/doi/10.1142/S2575900024300029 |
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| author | Jinmei Ren Yuzhu Jiang Qinghong Zeng Yang Wang Qianhong Yang Yulong Jiang |
| author_facet | Jinmei Ren Yuzhu Jiang Qinghong Zeng Yang Wang Qianhong Yang Yulong Jiang |
| author_sort | Jinmei Ren |
| collection | DOAJ |
| description | We review the potential effects and mechanisms of vitamin D (VD) in patients with BPPV-associated anxiety and depression, offering a new perspective for treating the population. Methods: Through a systematic review of existing literature, we analyzed the relationship between VD and comorbid anxiety and depression in BPPV, with a particular focus on neuroendocrine-immune modulation, genetic polymorphisms, oxidative stress, and neuroinflammation. Results: A comprehensive analysis indicates a significant correlation between low levels of VD and the occurrence, recurrence of BPPV, and the comorbid symptoms of anxiety and depression. VD may exert protective effects against BPPV-associated anxiety and depression by regulating neuroendocrine and immune responses, influencing gene expression, and alleviating oxidative stress and neuroinflammation. Conclusion: This review suggests that monitoring VD levels and appropriate supplementation could be crucial for the treatment of patients with BPPV comorbid with anxiety and depression. More research should further validate the specific mechanisms of action of VD and its clinical application value to provide more scientific guidance for the treatment of psychiatric disorders accompanying BPPV. |
| format | Article |
| id | doaj-art-ddfccf1d15ca4f4aad26abb6838533c8 |
| institution | DOAJ |
| issn | 2575-9000 2575-9019 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | World Scientific Publishing |
| record_format | Article |
| series | Traditional Medicine and Modern Medicine |
| spelling | doaj-art-ddfccf1d15ca4f4aad26abb6838533c82025-08-20T02:52:37ZengWorld Scientific PublishingTraditional Medicine and Modern Medicine2575-90002575-90192024-01-0107939910.1142/S2575900024300029The involvement of vitamin D in the pathogenesis of anxiety and depression in benign paroxysmal positional vertigo comorbiditiesJinmei Ren0Yuzhu Jiang1Qinghong Zeng2Yang Wang3Qianhong Yang4Yulong Jiang5Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai 201799, P. R. ChinaMental Health Center, Qingpu District, Shanghai 201799, P. R. ChinaZhujiajiao People’s Hospital, Qingpu District, Shanghai 201799, P. R. ChinaQingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai 201799, P. R. ChinaQingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai 201799, P. R. ChinaZhujiajiao People’s Hospital, Qingpu District, Shanghai 201799, P. R. ChinaWe review the potential effects and mechanisms of vitamin D (VD) in patients with BPPV-associated anxiety and depression, offering a new perspective for treating the population. Methods: Through a systematic review of existing literature, we analyzed the relationship between VD and comorbid anxiety and depression in BPPV, with a particular focus on neuroendocrine-immune modulation, genetic polymorphisms, oxidative stress, and neuroinflammation. Results: A comprehensive analysis indicates a significant correlation between low levels of VD and the occurrence, recurrence of BPPV, and the comorbid symptoms of anxiety and depression. VD may exert protective effects against BPPV-associated anxiety and depression by regulating neuroendocrine and immune responses, influencing gene expression, and alleviating oxidative stress and neuroinflammation. Conclusion: This review suggests that monitoring VD levels and appropriate supplementation could be crucial for the treatment of patients with BPPV comorbid with anxiety and depression. More research should further validate the specific mechanisms of action of VD and its clinical application value to provide more scientific guidance for the treatment of psychiatric disorders accompanying BPPV.https://www.worldscientific.com/doi/10.1142/S2575900024300029Vitamin Dbenign paroxysmal positional vertigodepressionpathogenesis |
| spellingShingle | Jinmei Ren Yuzhu Jiang Qinghong Zeng Yang Wang Qianhong Yang Yulong Jiang The involvement of vitamin D in the pathogenesis of anxiety and depression in benign paroxysmal positional vertigo comorbidities Traditional Medicine and Modern Medicine Vitamin D benign paroxysmal positional vertigo depression pathogenesis |
| title | The involvement of vitamin D in the pathogenesis of anxiety and depression in benign paroxysmal positional vertigo comorbidities |
| title_full | The involvement of vitamin D in the pathogenesis of anxiety and depression in benign paroxysmal positional vertigo comorbidities |
| title_fullStr | The involvement of vitamin D in the pathogenesis of anxiety and depression in benign paroxysmal positional vertigo comorbidities |
| title_full_unstemmed | The involvement of vitamin D in the pathogenesis of anxiety and depression in benign paroxysmal positional vertigo comorbidities |
| title_short | The involvement of vitamin D in the pathogenesis of anxiety and depression in benign paroxysmal positional vertigo comorbidities |
| title_sort | involvement of vitamin d in the pathogenesis of anxiety and depression in benign paroxysmal positional vertigo comorbidities |
| topic | Vitamin D benign paroxysmal positional vertigo depression pathogenesis |
| url | https://www.worldscientific.com/doi/10.1142/S2575900024300029 |
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