Toll-Like Receptors in Natural Killer Cells and Their Application for Immunotherapy
Innate immunity represents the first barrier for host defense against microbial infection. Toll-like receptors (TLRs) are the most well-defined PRRs with respect to PAMP recognition and induction of innate immune responses. They recognize pathogen-associated molecular patterns (PAMPs) and trigger in...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2020/2045860 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832566305772797952 |
|---|---|
| author | Ji-Yoon Noh Suk Ran Yoon Tae-Don Kim Inpyo Choi Haiyoung Jung |
| author_facet | Ji-Yoon Noh Suk Ran Yoon Tae-Don Kim Inpyo Choi Haiyoung Jung |
| author_sort | Ji-Yoon Noh |
| collection | DOAJ |
| description | Innate immunity represents the first barrier for host defense against microbial infection. Toll-like receptors (TLRs) are the most well-defined PRRs with respect to PAMP recognition and induction of innate immune responses. They recognize pathogen-associated molecular patterns (PAMPs) and trigger innate immune responses by inducing inflammatory cytokines, chemokines, antigen-presenting molecules, and costimulatory molecules. TLRs are expressed either on the cell surface or within endosomes of innate immune cells. NK cells are one of the innate immune cells and also express TLRs to recognize or respond to PAMPs. TLRs in NK cells induce the innate immune responses against bacterial and viral infections via inducing NK cytotoxicity and cytokine production. In this review, we will discuss the expression and cellular function of TLRs in NK cells and also introduce some therapeutic applications of TLR agonists for NK cell-mediated immunotherapy. |
| format | Article |
| id | doaj-art-ddfb1ab5a27e40bca6ed9528520fbe64 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-ddfb1ab5a27e40bca6ed9528520fbe642025-02-03T01:04:38ZengWileyJournal of Immunology Research2314-88612314-71562020-01-01202010.1155/2020/20458602045860Toll-Like Receptors in Natural Killer Cells and Their Application for ImmunotherapyJi-Yoon Noh0Suk Ran Yoon1Tae-Don Kim2Inpyo Choi3Haiyoung Jung4Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of KoreaImmunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of KoreaImmunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of KoreaImmunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of KoreaImmunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of KoreaInnate immunity represents the first barrier for host defense against microbial infection. Toll-like receptors (TLRs) are the most well-defined PRRs with respect to PAMP recognition and induction of innate immune responses. They recognize pathogen-associated molecular patterns (PAMPs) and trigger innate immune responses by inducing inflammatory cytokines, chemokines, antigen-presenting molecules, and costimulatory molecules. TLRs are expressed either on the cell surface or within endosomes of innate immune cells. NK cells are one of the innate immune cells and also express TLRs to recognize or respond to PAMPs. TLRs in NK cells induce the innate immune responses against bacterial and viral infections via inducing NK cytotoxicity and cytokine production. In this review, we will discuss the expression and cellular function of TLRs in NK cells and also introduce some therapeutic applications of TLR agonists for NK cell-mediated immunotherapy.http://dx.doi.org/10.1155/2020/2045860 |
| spellingShingle | Ji-Yoon Noh Suk Ran Yoon Tae-Don Kim Inpyo Choi Haiyoung Jung Toll-Like Receptors in Natural Killer Cells and Their Application for Immunotherapy Journal of Immunology Research |
| title | Toll-Like Receptors in Natural Killer Cells and Their Application for Immunotherapy |
| title_full | Toll-Like Receptors in Natural Killer Cells and Their Application for Immunotherapy |
| title_fullStr | Toll-Like Receptors in Natural Killer Cells and Their Application for Immunotherapy |
| title_full_unstemmed | Toll-Like Receptors in Natural Killer Cells and Their Application for Immunotherapy |
| title_short | Toll-Like Receptors in Natural Killer Cells and Their Application for Immunotherapy |
| title_sort | toll like receptors in natural killer cells and their application for immunotherapy |
| url | http://dx.doi.org/10.1155/2020/2045860 |
| work_keys_str_mv | AT jiyoonnoh tolllikereceptorsinnaturalkillercellsandtheirapplicationforimmunotherapy AT sukranyoon tolllikereceptorsinnaturalkillercellsandtheirapplicationforimmunotherapy AT taedonkim tolllikereceptorsinnaturalkillercellsandtheirapplicationforimmunotherapy AT inpyochoi tolllikereceptorsinnaturalkillercellsandtheirapplicationforimmunotherapy AT haiyoungjung tolllikereceptorsinnaturalkillercellsandtheirapplicationforimmunotherapy |