Concordance of HER2-low scoring in breast carcinomas among pathologists

Concordance of HER2-low scoring in breast carcinomas among pathologists

Abstract The results from DESTINY-Breast 04 and the subsequent introduction of trastuzumab-deruxtecan as a potential treatement for HER2-low breast cancer necessitated the reevaluation of HER2 scoring. The discordance in HER2 scoring reported in previous studies led us to initiate a regional ring st...

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Main Authors: Snježana Tomić, Tatjana Kapicl Ivković, Marija Milković Periša, Duško Đunđerović, Maja Jovičić Milentijević, Svetlana Oprić, Slobodanka Mitrović, Irena Jovanić, Savelina Popovska, Svitlana Bachurska, Desislava Tashkova, Kalin Kalchev, Ljiljana Vučković, Manuela Avirović, Emina Babarović, Melita Perić Balja, Čedna Tomasović, Jasmina Rajc, Irena Zagorac, Davor Oršolić, Toni Čeprnja
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Breast cancer
HER2-low
Trastuzumab-deruxtecan
Online Access:https://doi.org/10.1038/s41598-025-09839-6
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