Comparison of IL-17 and FOXP3+ Levels in Maternal and Children Leprosy Patients in Endemic and Nonendemic Areas
Leprosy, a chronic infection caused by M. leprae, has a complex transmission problem that makes eradication programs difficult. New cases and ongoing transmission of leprosy in endemic areas make individuals living in endemic environments vulnerable to leprosy. This can be caused by the dysregulatio...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Interdisciplinary Perspectives on Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2021/8879809 |
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| author | Flora Ramona Sigit Prakoeswa Faradiba Maharani Munawaroh Fitriah Jusak Nugraha Hardyanto Soebono Budi Prasetyo Santi Martini Dominicus Husada Hari Basuki Notobroto Muhammad Yulianto Listiawan Anang Endaryanto Cita Rosita Sigit Prakoeswa |
| author_facet | Flora Ramona Sigit Prakoeswa Faradiba Maharani Munawaroh Fitriah Jusak Nugraha Hardyanto Soebono Budi Prasetyo Santi Martini Dominicus Husada Hari Basuki Notobroto Muhammad Yulianto Listiawan Anang Endaryanto Cita Rosita Sigit Prakoeswa |
| author_sort | Flora Ramona Sigit Prakoeswa |
| collection | DOAJ |
| description | Leprosy, a chronic infection caused by M. leprae, has a complex transmission problem that makes eradication programs difficult. New cases and ongoing transmission of leprosy in endemic areas make individuals living in endemic environments vulnerable to leprosy. This can be caused by the dysregulation of immune system in individuals living in leprosy-endemic areas. Although the number of male leprosy patients is higher, female leprosy patients have more impact on the family health status due to close contact with family members, roles in the household, and parenting. This could cause the increased number of children leprosy patients. We investigated the dysregulation of immune system by comparing IL-17 and FOXP3+ levels occurring in maternal and child leprosy patients in endemic and nonendemic areas. The results of the study found a statistically significant difference in IL-17 levels between the MB leprosy patient group and the control group (p=0.048), where higher levels of IL-17 are observed in the control group. A significant difference also was found in FOXP3+ levels between the group of healthy children living in endemic and those living in nonendemic areas (p=0.047), where higher FOXP3+ is observed in the healthy children living in endemic areas group. |
| format | Article |
| id | doaj-art-ddbf6216291c45b49500450d0d14be2f |
| institution | Kabale University |
| issn | 1687-708X 1687-7098 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Interdisciplinary Perspectives on Infectious Diseases |
| spelling | doaj-art-ddbf6216291c45b49500450d0d14be2f2025-02-03T05:49:27ZengWileyInterdisciplinary Perspectives on Infectious Diseases1687-708X1687-70982021-01-01202110.1155/2021/88798098879809Comparison of IL-17 and FOXP3+ Levels in Maternal and Children Leprosy Patients in Endemic and Nonendemic AreasFlora Ramona Sigit Prakoeswa0Faradiba Maharani1Munawaroh Fitriah2Jusak Nugraha3Hardyanto Soebono4Budi Prasetyo5Santi Martini6Dominicus Husada7Hari Basuki Notobroto8Muhammad Yulianto Listiawan9Anang Endaryanto10Cita Rosita Sigit Prakoeswa11Doctoral Program, Faculty of Medicine, Airlangga University, Surabaya, IndonesiaFaculty of Medicine, Sebelas Maret University, Surakarta, IndonesiaDepartment of Clinical Pathology, Faculty of Medicine, Airlangga University, Dr. Soetomo General Academic Hospital, Surabaya, IndonesiaDepartment of Clinical Pathology, Faculty of Medicine, Airlangga University, Dr. Soetomo General Academic Hospital, Surabaya, IndonesiaDepartment of Dermatology and Venereology, Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, IndonesiaDepartment of Obstetrics and Gynecology, Faculty of Medicine, Airlangga University, Dr. Soetomo General Academic Hospital, Surabaya, IndonesiaFaculty of Public Health, Airlangga University, Surabaya, IndonesiaDepartment of Pediatric, Faculty of Medicine, Airlangga University, Dr. Soetomo General Academic Hospital, Surabaya, IndonesiaFaculty of Public Health, Airlangga University, Surabaya, IndonesiaDepartment of Dermatology and Venereology, Faculty of Medicine, Airlangga University, Dr. Soetomo General Academic Hospital, Surabaya, IndonesiaDepartment of Pediatric, Faculty of Medicine, Airlangga University, Dr. Soetomo General Academic Hospital, Surabaya, IndonesiaDepartment of Dermatology and Venereology, Faculty of Medicine, Airlangga University, Dr. Soetomo General Academic Hospital, Surabaya, IndonesiaLeprosy, a chronic infection caused by M. leprae, has a complex transmission problem that makes eradication programs difficult. New cases and ongoing transmission of leprosy in endemic areas make individuals living in endemic environments vulnerable to leprosy. This can be caused by the dysregulation of immune system in individuals living in leprosy-endemic areas. Although the number of male leprosy patients is higher, female leprosy patients have more impact on the family health status due to close contact with family members, roles in the household, and parenting. This could cause the increased number of children leprosy patients. We investigated the dysregulation of immune system by comparing IL-17 and FOXP3+ levels occurring in maternal and child leprosy patients in endemic and nonendemic areas. The results of the study found a statistically significant difference in IL-17 levels between the MB leprosy patient group and the control group (p=0.048), where higher levels of IL-17 are observed in the control group. A significant difference also was found in FOXP3+ levels between the group of healthy children living in endemic and those living in nonendemic areas (p=0.047), where higher FOXP3+ is observed in the healthy children living in endemic areas group.http://dx.doi.org/10.1155/2021/8879809 |
| spellingShingle | Flora Ramona Sigit Prakoeswa Faradiba Maharani Munawaroh Fitriah Jusak Nugraha Hardyanto Soebono Budi Prasetyo Santi Martini Dominicus Husada Hari Basuki Notobroto Muhammad Yulianto Listiawan Anang Endaryanto Cita Rosita Sigit Prakoeswa Comparison of IL-17 and FOXP3+ Levels in Maternal and Children Leprosy Patients in Endemic and Nonendemic Areas Interdisciplinary Perspectives on Infectious Diseases |
| title | Comparison of IL-17 and FOXP3+ Levels in Maternal and Children Leprosy Patients in Endemic and Nonendemic Areas |
| title_full | Comparison of IL-17 and FOXP3+ Levels in Maternal and Children Leprosy Patients in Endemic and Nonendemic Areas |
| title_fullStr | Comparison of IL-17 and FOXP3+ Levels in Maternal and Children Leprosy Patients in Endemic and Nonendemic Areas |
| title_full_unstemmed | Comparison of IL-17 and FOXP3+ Levels in Maternal and Children Leprosy Patients in Endemic and Nonendemic Areas |
| title_short | Comparison of IL-17 and FOXP3+ Levels in Maternal and Children Leprosy Patients in Endemic and Nonendemic Areas |
| title_sort | comparison of il 17 and foxp3 levels in maternal and children leprosy patients in endemic and nonendemic areas |
| url | http://dx.doi.org/10.1155/2021/8879809 |
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