HCV Proteins and Immunoglobulin Variable Gene (IgV) Subfamilies in HCV-Induced Type II Mixed Cryoglobulinemia: A Concurrent Pathogenetic Role
The association between hepatitis C virus (HCV) infection and type II mixed cryoglobulinemia (MCII) is well established, but the role played by distinct HCV proteins and by specific components of the anti-HCV humoral immune response remains to be clearly defined. It is widely accepted that HCV drive...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/705013 |
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| author | Giuseppe Sautto Nicasio Mancini Laura Solforosi Roberta A. Diotti Massimo Clementi Roberto Burioni |
| author_facet | Giuseppe Sautto Nicasio Mancini Laura Solforosi Roberta A. Diotti Massimo Clementi Roberto Burioni |
| author_sort | Giuseppe Sautto |
| collection | DOAJ |
| description | The association between hepatitis C virus (HCV) infection and type II mixed cryoglobulinemia (MCII) is well established, but the role played by distinct HCV proteins and by specific components of the anti-HCV humoral immune response remains to be clearly defined. It is widely accepted that HCV drives the expansion of few B-cell clones expressing a restricted pool of selected immunoglobulin variable (IgV) gene subfamilies frequently endowed with rheumatoid factor (RF) activity. Moreover, the same IgV subfamilies are frequently observed in HCV-transformed malignant B-cell clones occasionally complicating MCII. In this paper, we analyze both the humoral and viral counterparts at the basis of cryoglobulins production in HCV-induced MCII, with particular attention reserved to the single IgV subfamilies most frequently involved. |
| format | Article |
| id | doaj-art-ddbf42a40f0e46a19ab775aeccd924b8 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-ddbf42a40f0e46a19ab775aeccd924b82025-02-03T05:47:06ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/705013705013HCV Proteins and Immunoglobulin Variable Gene (IgV) Subfamilies in HCV-Induced Type II Mixed Cryoglobulinemia: A Concurrent Pathogenetic RoleGiuseppe Sautto0Nicasio Mancini1Laura Solforosi2Roberta A. Diotti3Massimo Clementi4Roberto Burioni5Laboratorio di Microbiologia e Virologia, Università Vita-Salute San Raffaele, Via Olgettina, 58, 20132 Milano, ItalyLaboratorio di Microbiologia e Virologia, Università Vita-Salute San Raffaele, Via Olgettina, 58, 20132 Milano, ItalyLaboratorio di Microbiologia e Virologia, Università Vita-Salute San Raffaele, Via Olgettina, 58, 20132 Milano, ItalyLaboratorio di Microbiologia e Virologia, Università Vita-Salute San Raffaele, Via Olgettina, 58, 20132 Milano, ItalyLaboratorio di Microbiologia e Virologia, Università Vita-Salute San Raffaele, Via Olgettina, 58, 20132 Milano, ItalyLaboratorio di Microbiologia e Virologia, Università Vita-Salute San Raffaele, Via Olgettina, 58, 20132 Milano, ItalyThe association between hepatitis C virus (HCV) infection and type II mixed cryoglobulinemia (MCII) is well established, but the role played by distinct HCV proteins and by specific components of the anti-HCV humoral immune response remains to be clearly defined. It is widely accepted that HCV drives the expansion of few B-cell clones expressing a restricted pool of selected immunoglobulin variable (IgV) gene subfamilies frequently endowed with rheumatoid factor (RF) activity. Moreover, the same IgV subfamilies are frequently observed in HCV-transformed malignant B-cell clones occasionally complicating MCII. In this paper, we analyze both the humoral and viral counterparts at the basis of cryoglobulins production in HCV-induced MCII, with particular attention reserved to the single IgV subfamilies most frequently involved.http://dx.doi.org/10.1155/2012/705013 |
| spellingShingle | Giuseppe Sautto Nicasio Mancini Laura Solforosi Roberta A. Diotti Massimo Clementi Roberto Burioni HCV Proteins and Immunoglobulin Variable Gene (IgV) Subfamilies in HCV-Induced Type II Mixed Cryoglobulinemia: A Concurrent Pathogenetic Role Clinical and Developmental Immunology |
| title | HCV Proteins and Immunoglobulin Variable Gene (IgV) Subfamilies in HCV-Induced Type II Mixed Cryoglobulinemia: A Concurrent Pathogenetic Role |
| title_full | HCV Proteins and Immunoglobulin Variable Gene (IgV) Subfamilies in HCV-Induced Type II Mixed Cryoglobulinemia: A Concurrent Pathogenetic Role |
| title_fullStr | HCV Proteins and Immunoglobulin Variable Gene (IgV) Subfamilies in HCV-Induced Type II Mixed Cryoglobulinemia: A Concurrent Pathogenetic Role |
| title_full_unstemmed | HCV Proteins and Immunoglobulin Variable Gene (IgV) Subfamilies in HCV-Induced Type II Mixed Cryoglobulinemia: A Concurrent Pathogenetic Role |
| title_short | HCV Proteins and Immunoglobulin Variable Gene (IgV) Subfamilies in HCV-Induced Type II Mixed Cryoglobulinemia: A Concurrent Pathogenetic Role |
| title_sort | hcv proteins and immunoglobulin variable gene igv subfamilies in hcv induced type ii mixed cryoglobulinemia a concurrent pathogenetic role |
| url | http://dx.doi.org/10.1155/2012/705013 |
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