Entacapone’s therapeutic potential in renal fibrosis by targeting miR-34a/TGFβ1/Smad2 signaling: an experimental rat model study

Entacapone’s therapeutic potential in renal fibrosis by targeting miR-34a/TGFβ1/Smad2 signaling: an experimental rat model study

Abstract Chronic kidney disorder is a rising danger to health that affects a significant percentage of older adults, and a crucial stage in its development is fibrosis. MicroRNAs and transforming_ growth factor-β1(TGF-β1) /SMAD2 signal pathway significantly regulate this process. miR-34a promotes ex...

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Bibliographic Details
Main Authors: Yosra M. Magdy, Sherif A. Kamar, Tamer M. M. Abuamara, Yomna M. Tamim, Hayam Ateyya, Marwa Tarek, Nehal Samir, Reham Hussein
Format: Article
Language:English
Published: SpringerOpen 2025-06-01
Series:Future Journal of Pharmaceutical Sciences
Subjects:
Bcl-2
CCl4
Entacapone
miR-34a
Oxidative stress
Renal fibrosis
Online Access:https://doi.org/10.1186/s43094-025-00829-z
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