Sildenafil alters biogenic amines and increases oxidative damage in brain regions of insulin-hypoglycemic rats

Sildenafil alters biogenic amines and increases oxidative damage in brain regions of insulin-hypoglycemic rats

The aim of the present study was to determine the effect of sildenafil on dopamine, 5-hydroxyindol acetic acid (5-HIAA) and selected biomarkers of oxidative stress in the brain of hypoglycemic rats. The animals were treated intraperitoneally as follows: group 1 (control), saline solution; group 2, i...

Full description

Saved in:

Bibliographic Details
Main Authors:	Guzmán David Calderón, Brizuela Norma Osnaya, Herrera Maribel Ortíz, Peraza Armando Valenzuela, Mejía Gerardo Barragán, Olguín Hugo Juárez, Jiménez Francisca Trujillo
Format:	Article
Language:	English
Published:	Sciendo 2020-03-01
Series:	Acta Pharmaceutica
Subjects:	sildenafil rat hypoglycemia biogenic amines glutathione h2o2 lipid peroxidation
Online Access:	https://doi.org/10.2478/acph-2020-0016
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

The Impact of Grape Maceration on Quality and Biogenic Amine Formation in Slovak Tokaj Wines: Examination of Microbial, Chemical and Sensory Properties
by: Boris Semjon, et al.
Published: (2025-01-01)

Efficacy of an Aromatic Vinegar in Reducing Psychrotrophic Bacteria and Biogenic Amines in Salmon Fillets (Salmo salar) Stored in Modified Atmosphere Packaging
by: Jessica Di Toro, et al.
Published: (2019-11-01)

Effects of potassium lactate on sensory attributes, bacterial community succession and biogenic amines formation in Rugao ham
by: Renyong Liao, et al.
Published: (2024-01-01)

Effects of lactic acid bacterial and chemical additives on the quality and biogenic amine production of oat silage at low temperature
by: Yuhan Huang, et al.
Published: (2025-01-01)

The Health Impact of Cocoa from Cultivation to the Formation of Biogenic Amines: An Updated Review
by: Antonello Paparella, et al.
Published: (2025-01-01)

Effect of a compound starter cultures inoculation on bacterial profile and biogenic amine accumulation in Chinese Sichuan sausages
by: Hongyang Ren, et al.
Published: (2022-03-01)

Sildenafil as a Salvage Treatment for Ovarian Torsion: A Rat Model
by: Didem Alkas Yaginc, et al.
Published: (2023-12-01)

Effects of Sildenafil and Vitamin E on Paraquat-Induced Pulmonary Fibrosis in Rats
by: Fouziyeh Siahpour, et al.
Published: (2024-12-01)

Comparison of Milrinone with Sildenafil for the Treatment of Persistent Pulmonary Hypertension of the Newborn
by: Imtiaz Ahmad, et al.
Published: (2024-06-01)

Rosuvastatin, Sildenafil and Their Combination in Monocrotaline-Induced Pulmonary Hypertension in Rat
by: Jasińska-Stroschein Magdalena, et al.
Published: (2014-09-01)

Recurrent nocturnal hypoglycemic hemiplegia: a case report and review of the literature
by: Hanako Toyama, et al.
Published: (2024-04-01)

A modern scientific perspective on the flavor and functional properties of diverse teas in traditional cuisine “tea-flavored fish”: From macroscopic quality to microscopic variations
by: Wenxia Wang, et al.
Published: (2025-01-01)

Fatal Haemorrhagic Stroke Due to Concomitant Abuse of Sildenafil and Alcohol: A Case Report
by: Jithin Laxminarayana V, et al.
Published: (2025-02-01)

Charactering the spoilage mechanism of “three sticks” of Jinhua ham
by: Changyu Zhou, et al.
Published: (2022-09-01)

The hypoglycemic potential of phenolics from functional foods and their mechanisms
by: Oksana Golovinskaia, et al.
Published: (2023-07-01)

Effect of biogenic polyamines on sliding motility of mycobacteria in the presence of antibiotics
by: I. V. Tsyganov, et al.
Published: (2022-09-01)

Redox Potential and Its Control in Research and Commercial Wine Fermentations
by: James Nelson, et al.
Published: (2025-01-01)

Coated pellets with delayed-release glucose for prevention of hypoglycemic episodes
by: Sabadková Dana, et al.
Published: (2016-06-01)

CO2 capture performance and foaming mechanism of modified amine-based absorbents: A study based on molecular dynamics
by: Yucong Ge, et al.
Published: (2025-06-01)

Trace amine-associated receptors (TAARs)2-9 knockout mice exhibit reduced wakefulness and disrupted REM sleep
by: Sunmee Park, et al.
Published: (2025-01-01)

Study on the comparison between Bosentan and Macitentan in the treatment of persistent pulmonary hypertension of the newborns, simultaneously on sildenafil: A randomized double-blinded non-inferiority parallel clinical trial
by: Mandana Kashaki, et al.
Published: (2025-01-01)

Assisted Egg White Biogenic Synthesis for Elaboration of ZnO Nanoparticles
by: Elena Andreea Vijan, et al.
Published: (2025-01-01)

The role of flavonoids in mitigating food originated heterocyclic aromatic amines that concerns human wellness
by: Hui Teng, et al.
Published: (2023-07-01)

An application of natural language processing for hypoglycemic event identification in patients with diabetes mellitus
by: J.E. Camacho-Cogollo, et al.
Published: (2025-06-01)

Amine modified sodium alginate: Synthesis, characterization and in vivo evaluation in rainbow trout (Oncorhynchus mykiss)
by: Samira Salarvand, et al.
Published: (2025-03-01)

Effectiveness of a novel amine + zinc + fluoride toothpaste in reducing plaque and gingivitis: results of a six-month randomized controlled trial
by: Dutmanee Seriwatanachai, et al.
Published: (2025-02-01)

l-Histidine-functionalized KIT-6 with embedded palladium nanoparticles as an efficient heterogeneous catalyst for oxidation of sulfide to sulfoxide and amination of aryl halides
by: Nafis Ahmad, et al.
Published: (2025-01-01)

THE PERMISSIBLE INPUT OF BIOGENIC ELEMENTS TO WATER BODIES WITH SLOWED AND MODERATE WATER EXCHANGE
by: Aleksandr N. Popov
Published: (2020-08-01)

Use of DIABAX feed additive and a biogenic stimulant in calves during their rehabilitation after gastrointestinal infections
by: N. V. Shanshin
Published: (2024-06-01)

The size-fractionated composition of particulate biogenic silica and its ecological significance in the Changjiang Estuary area
by: Xizhen Liu, et al.
Published: (2025-01-01)

Effects of biogenic CBM generation on microcrystalline and functional groups of high-volatile bituminous coal
by: Aikuan Wang, et al.
Published: (2025-02-01)

The Effect of Cumin on the Formation of <i>β</i>-Carboline Heterocyclic Amines in Smoked Meat and Simulated Systems
by: Xiuxiu Liu, et al.
Published: (2025-01-01)

A Case of Persistent Hypoglycemia: Emphasizing the Role of Kidneys
by: Praveen Govindaraju, et al.
Published: (2024-04-01)

Synthesis, in silico and antimicrobial activity study of substituted aromatic imines and their corresponding amines
by: Hanna Abbo, et al.
Published: (2025-01-01)

Associations of prenatal urinary melamine, melamine analogues, and aromatic amines with gestational duration and fetal growth in the ECHO Cohort
by: Giehae Choi, et al.
Published: (2025-01-01)

Crinum jagus (J. Thomps. Dandy): Antioxidant and protective properties as a medicinal plant on toluene-induced oxidative stress damages in liver and kidney of rats
by: Mariama, Salihu, et al.
Published: (2023)

Hypoglycemia and hospital mortality in critically ill patients
by: Hsuan-Fan Yeh, et al.
Published: (2025-01-01)

Drug resistant epilepsy as the consequence of inadequate control of type 1 diabetes
by: Ewa M. Sokolewicz, et al.
Published: (2024-04-01)

The Development of Methods of BLOTCHIP<sup>®</sup>-MS for Peptidome: Small Samples in Tuberous Sclerosis
by: Kunio Yui, et al.
Published: (2025-01-01)

Investigation of the dose and structure effects of lipid oxidation products aldehydes on the generation of heterocyclic amines: A case study of 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP)
by: Mantong Zhao, et al.
Published: (2025-01-01)