Global dissemination of conjugative virulence plasmids co-harboring hypervirulence and multidrug resistance genes in Klebsiella pneumoniae

Global dissemination of conjugative virulence plasmids co-harboring hypervirulence and multidrug resistance genes in Klebsiella pneumoniae

ABSTRACT Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKp) has led to a high mortality rate in the clinical setting and garnered significant attention in the clinical and scientific communities. It is still not clear which major mechanisms mediate the rapid evolution of hvKp in clin...

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Bibliographic Details
Main Authors: Qi Xu, Ruanyang Sun, Xiaoxuan Liu, Heng Heng, Xuemei Yang, Miaomiao Xie, Chen Yang, Lianwei Ye, Edward Wai-Chi Chan, Rong Zhang, Sheng Chen
Format: Article
Language:English
Published: American Society for Microbiology 2025-04-01
Series:mSystems
Subjects:
Klebsiella pneumoniae
conjugative
hypervirulence
multidrug resistance
pVir-MDR
Online Access:https://journals.asm.org/doi/10.1128/msystems.01675-24
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