Therapeutic potential of Triptolide in inhibiting breast cancer-induced bone destruction – PTHrP as a therapeutic target

Therapeutic potential of Triptolide in inhibiting breast cancer-induced bone destruction – PTHrP as a therapeutic target

IntroductionBone metastases are a common and severe complication in advanced breast cancer, affecting approximately 65% to 70% of patients and significantly reducing survival time. Osteolytic bone metastases, in particular, are challenging to manage due to their association with skeletal-related eve...

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Bibliographic Details
Main Authors: Wu Di, Li Minghan, Huang Zining, Zhou Chunshi, Hu Xiangyu, Wang Zidong, Wu Gang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
Triptolide
osteoclast
osteoblast
bone metastasis
breast cancer
PTHrP
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1512631/full
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